2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. JAK PROTACs
  4. SJ1008030 TFA

SJ1008030 (compound 8) TFA is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia.

For research use only. We do not sell to patients.

SJ1008030 TFA Chemical Structure

SJ1008030 TFA Chemical Structure

CAS No. : 2863634-97-1

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Based on 1 publication(s) in Google Scholar

Other Forms of SJ1008030 TFA:

SJ1008030 TFA Related Antibodies

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Description

SJ1008030 (compound 8) TFA is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia[1].

IC50 & Target[1]

JAK2

 

In Vitro

SJ1008030 (compound 8) (72 h) TFA shows activity in CRLF2r cell lines (MHH-CALL-4), with an IC50 of 5.4 nM[1].
SJ1008030 (0-4.3 μM; 72 h) TFA degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH–CALL-4 cells[1].
SJ1008030 (0-10 μM; 24h) TFA dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of JAK-STAT signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJ1008030 TFA Related Antibodies
Molecular Weight

987.96

Formula

C44H44F3N13O9S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(CC)(N1CC(N2C=C(C=N2)C3=C4C=CNC4=NC(NC5=CC=C(C=C5)C(NCCN6CCN(CC6)C7=CC=C8C(N(C9CCC(NC9=O)=O)C(C8=C7)=O)=O)=O)=N3)(CC#N)C1)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.81%

COA (254 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)
References
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SJ1008030 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ10080302863634-97-1SJ 1008030SJ-1008030JAKPROTACsJanus kinaseantileukemiCRLF2r ALLMHH–CALL-4JAK-STAT signaling pathwaydegraderInhibitorinhibitorinhibit

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