2. Anti-infection
  3. Bacterial
  4. T3SS-IN-5

T3SS-IN-5 (Compound F9) is a specific inhibitor of the type III secretion system (T3SS). T3SS-IN-5 reduces bacterial pathogenicity without affecting bacterial viability by inhibiting the expression of genes associated with T3SS.

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T3SS-IN-5 Chemical Structure

T3SS-IN-5 Chemical Structure

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T3SS-IN-5 Related Antibodies

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Description

T3SS-IN-5 (Compound F9) is a specific inhibitor of the type III secretion system (T3SS). T3SS-IN-5 reduces bacterial pathogenicity without affecting bacterial viability by inhibiting the expression of genes associated with T3SS[1].

In Vitro

T3SS-IN-5 (200 μM; 48 h) has no statistically significant effect on the viability of Xcc[1].
T3SS-IN-5 (200 μM; 5 d) causes a significant reduction in Xcc-jx-6-induced hypersensitive response (HR) in Nicotiana benthamiana[1].
T3SS-IN-5 (200 μM; 4-7 d) reduces the ulcerative symptoms of orach orange and is more effective than bismerthiazol at the same concentration[1].
T3SS-IN-5 (200 μM; 16 h) significantly reduces the relative incidence of Xcc[1].
T3SS-IN-5 (200 μM; 48 h-5 d) does not affect other virulence factors of Xcc, including extracellular enzymes activity, EPS activity, motility, and biofilm formation[1].
T3SS-IN-5 (100-200 μM; 4 d) combines with Burkholderia anthina hN-8 can further improve the inhibition of Xcc[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T3SS-IN-5 Related Antibodies

RT-PCR[1]

Cell Line: hrp cluster
Concentration: 200 μM
Incubation Time: 16 h
Result: Significantly reduced the expression levels of key T3SS genes (hrpG, hrpX, hrpE, hrcC, hrcT, and hpa1) in the Xcc.
Significantly reduced the expression of the critical disease susceptibility gene, Citrus sinensis lateral organ boundary 1 (CsLOB1).
Molecular Weight

314.43

Formula

C16H14N2OS2
Unlabeled CAS

SMILES

OC(C1=NN=C(SCC2=CC=CC=C2)S1)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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T3SS-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T3SS-IN-5Bacterialcitrus cankerXanthomonas citri subsp. citri (Xcc)type III secretion system (T3SS)mandelic acid derivativesquorum quenchingInhibitorinhibitorinhibit

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