2. PROTAC Apoptosis
  3. PROTACs IAP Caspase
  4. TD1092

TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research.

For research use only. We do not sell to patients.

TD1092 Chemical Structure

TD1092 Chemical Structure

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1 mg USD 1130 In-stock
5 mg USD 2600 In-stock
10 mg USD 3900 In-stock
25 mg USD 7800 In-stock
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Based on 1 publication(s) in Google Scholar

TD1092 Related Antibodies

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  • Biological Activity

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Description

TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research[1].

IC50 & Target[1]

cIAP1

 

cIAP2

 

XIAP

 

Caspase 3

 

Caspase-7

 

In Vitro

TD1092 (0.1 μM-10 μM; 0.5-6 h) potently degrades cIAP1, cIAP2, and XIAP in a dose- and time-dependent manner[1].
TD1092 (0.01, 0.1 and 1 μM; 18 h) activates caspase 3/7 in MCF-7 cells[1].
TD1092 (1 μM; 48 h and 72 h) promotes cancer cell death[1].
TD1092 (0.1 μM; 24 h) inhibits TNFα-induced migration and invasion against triple-negative breast cancer cells[1].
TD1092 (1 μM; 6 h) inhibits TNFα-induced NF-κB signaling pathway and epithelial-mesenchymal transition (EMT) via IAP degradation[1].
TD1092 (1 μM; 72 h) inhibits MCF-7 cells growth with an IG50 value of 0.395 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TD1092 Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: (1) 0, 0.1, 1, 10 μM or 0.1 μM
(2) 0.1 μM, with or without 100 ng/mL TNFα
Incubation Time: 18 hours or 0.5, 1, 2, 4, 6 hours for (1) and 4 hours for (2)
Result: Dose- and time-dependently decreases the protein level of cIAP1, cIAP2, and XIAP.
Inhibited the phosphorylation of IKK, IkBα, p65, and p38 mediated by TNFα.
Counterbalanced the effect of TNFα on the levels of E-cadherin (CDH1; an epithelial marker) and vimentin (VIM; a mesenchymal marker).

Cell Migration Assay [1]

Cell Line: MDA-MB-231 and MDA-MB-157 cells
Concentration: 0.1 μM; with or without 100 ng/mL TNFα
Incubation Time: 24 hours
Result: Inhibited TNFα-induced (100 ng/mL) migration and invasion against two triple-negative breast cancer (TNBC; MDA-MB-231 and MDA-MB-157) cell lines.
Molecular Weight

987.19

Formula

C55H70N8O9
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N[C@@H]1CCCC2=C1C=CC=C2)[C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C(C)(C)C)=O)CC4=C(C=CC(OCCCCCCCCNC(C(C5)CN5C(C=C6C7=O)=CC=C6C(N7C8CCC(NC8=O)=O)=O)=O)=C4)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (101.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0130 mL 5.0649 mL 10.1298 mL
5 mM 0.2026 mL 1.0130 mL 2.0260 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0130 mL 5.0649 mL 10.1298 mL 25.3244 mL
5 mM 0.2026 mL 1.0130 mL 2.0260 mL 5.0649 mL
10 mM 0.1013 mL 0.5065 mL 1.0130 mL 2.5324 mL
15 mM 0.0675 mL 0.3377 mL 0.6753 mL 1.6883 mL
20 mM 0.0506 mL 0.2532 mL 0.5065 mL 1.2662 mL
25 mM 0.0405 mL 0.2026 mL 0.4052 mL 1.0130 mL
30 mM 0.0338 mL 0.1688 mL 0.3377 mL 0.8441 mL
40 mM 0.0253 mL 0.1266 mL 0.2532 mL 0.6331 mL
50 mM 0.0203 mL 0.1013 mL 0.2026 mL 0.5065 mL
60 mM 0.0169 mL 0.0844 mL 0.1688 mL 0.4221 mL
80 mM 0.0127 mL 0.0633 mL 0.1266 mL 0.3166 mL
100 mM 0.0101 mL 0.0506 mL 0.1013 mL 0.2532 mL
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TD1092 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TD1092TD 1092TD-1092PROTACsIAPCaspaseInhibitorinhibitorinhibit

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