Tesirine intermediate-1

Cat. No.: HY-47820 Purity: 99.41%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.

For research use only. We do not sell to patients.

Tesirine intermediate-1 Chemical Structure

CAS No. : 1430738-05-8

Size	Price	Stock	Quantity
1 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 510	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1730	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2770	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4440	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Purity & Documentation
References
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Description

Molecular Weight

580.86

Formula

C₂₈H₄₈N₂O₇Si₂

CAS No.

1430738-05-8

Appearance

Solid

Color

White to off-white

SMILES

CC(C)[Si](C(C)C)(C(C)C)OC1=C(C=C(C([N+]([O-])=O)=C1)C(N2[C@@H](CC(C2)=O)CO[Si](C)(C)C(C)(C)C)=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (172.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7216 mL	8.6079 mL	17.2159 mL
5 mM	0.3443 mL	1.7216 mL	3.4432 mL
10 mM	0.1722 mL	0.8608 mL	1.7216 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (230 KB) HNMR (276 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Howard, et al. Process for the preparation of intermediates useful for the synthesis of pyrrolobenzodiazepine dimers. World Intellectual Property Organization, WO2013053872 A1. 2013-04-18.

[2]. Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7216 mL	8.6079 mL	17.2159 mL	43.0396 mL
	5 mM	0.3443 mL	1.7216 mL	3.4432 mL	8.6079 mL
	10 mM	0.1722 mL	0.8608 mL	1.7216 mL	4.3040 mL
	15 mM	0.1148 mL	0.5739 mL	1.1477 mL	2.8693 mL
	20 mM	0.0861 mL	0.4304 mL	0.8608 mL	2.1520 mL
	25 mM	0.0689 mL	0.3443 mL	0.6886 mL	1.7216 mL
	30 mM	0.0574 mL	0.2869 mL	0.5739 mL	1.4347 mL
	40 mM	0.0430 mL	0.2152 mL	0.4304 mL	1.0760 mL
	50 mM	0.0344 mL	0.1722 mL	0.3443 mL	0.8608 mL
	60 mM	0.0287 mL	0.1435 mL	0.2869 mL	0.7173 mL
	80 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.5380 mL
	100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.4304 mL