2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. PARP Microtubule/Tubulin
  4. Tubulin/PARP-IN-1

Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase.

For research use only. We do not sell to patients.

Tubulin/PARP-IN-1 Chemical Structure

Tubulin/PARP-IN-1 Chemical Structure

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Tubulin/PARP-IN-1 Related Antibodies

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Description

Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase[1].

IC50 & Target

IC50: 74 nM (PARP1), 109 nM (PARP2), 1.4 μM (Microtubule/Tubulin)[1]
Molecular Weight

308.30

Formula

C19H13FO3
SMILES

O=C1C=C(OC2=C1C=CC(C3=COC=C3)=C2)C4C=CC(F)=CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin/PARP-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/PARP-IN-1PARPMicrotubule/Tubulinpoly ADP ribose polymeraseFlavonebenzopyranendometrial cancerinhibitortubulinInhibitorinhibit

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