2. Metabolic Enzyme/Protease Apoptosis
  3. PAI-1 Apoptosis
  4. UCD38B hydrochloride

UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis.

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UCD38B hydrochloride Chemical Structure

UCD38B hydrochloride Chemical Structure

CAS No. : 1115177-19-9

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UCD38B hydrochloride Related Antibodies

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Description

UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis[1][2].

In Vitro

UCD38B hydrochloride (10-250 μM; 1h) has cell permeant in U87MG cells[1].
UCD38B hydrochloride (10-250 μM; 1h) inhibits cell growth with an IC50 value of 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UCD38B hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: U87MG cells
Concentration: 10, 100, and 250 μM
Incubation Time: 24 hours
Result: Inhibited cell growth in a dose-dependent manner.
Formula

C15H16ClN7O3.xHCl
CAS No.
SMILES

O=C(CNC1=C(Cl)N=C(C(NC(N)=N)=O)C(N)=N1)OCC2=CC=CC=C2.Cl.[x]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UCD38B hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCD38B1115177-19-9PAI-1ApoptosisPlasminogen activator inhibitor-1cell permeantU87MG celluPAapoptotic inducible factorInhibitorinhibitorinhibit

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