2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis
  4. VEGFR-2-IN-14

VEGFR-2-IN-14 (Compound 5) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-14 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis.

For research use only. We do not sell to patients.

VEGFR-2-IN-14 Chemical Structure

VEGFR-2-IN-14 Chemical Structure

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VEGFR-2-IN-14 Related Antibodies

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Description

VEGFR-2-IN-14 (Compound 5) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-14 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis[1].

IC50 & Target

VEGFR2

 

In Vitro

VEGFR-2-IN-14 (Compound 5) shows cytotoxic activities with IC50 values of 9.7 ± 0.75 µM and 8.8 ± 0.69 µM against MCF-7 and HepG2 cells, respectively[1].
VEGFR-2-IN-14 shows VEGFR-2 inhibitory effects with concentrations of 610.4 pg/ml[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-14 Related Antibodies
Molecular Weight

433.52

Formula

C24H23N3O3S
SMILES

COC1=CC=C2C=C(C=CC2=C1)[C@@H](C3=NN=C(O3)SCC(NCC4=CC=CC=C4)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-14VEGFRApoptosisVascular endothelial growth factor receptorHepG2MCF-7caspase-3Inhibitorinhibitorinhibit

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VEGFR-2-IN-14
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