LPS

By Targets:	ADC Cytotoxin (1) Adenosine Receptor (1) AIM2 (1) Akt (4) AMPK (5) Amyloid-β (4) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (7) Apoptosis (21) Autophagy (4) Bacterial (25) Bcl-2 Family (1) Beta-lactamase (1) Biochemical Assay Reagents (5) Btk (1) Calcium Channel (1) Cannabinoid Receptor (1) Casein Kinase (3) Caspase (6) Cathepsin (1) CDK (1) CMV (1) Complement System (1) COX (34) CXCR (1) Cytochrome P450 (1) Dengue virus (1) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Dynamin (1) E1/E2/E3 Enzyme (1) EGFR (2) Elastase (1) Endogenous Metabolite (12) Epigenetic Reader Domain (6) ERK (9) FAK (1) Flavivirus (2) Fluorescent Dye (2) Formyl Peptide Receptor (FPR) (1) Fungal (6) Glucocorticoid Receptor (3) Glucosidase (1) GLUT (1) GSK-3 (2) Guanylate Cyclase (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) Histone Demethylase (2) HIV (3) HSV (1) IGF-1R (1) IKK (15) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (5) Interleukin Related (28) IRAK (7) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (5) JAK (3) JNK (5) Keap1-Nrf2 (8) Leukotriene Receptor (1) Liposome (23) Lipoxygenase (6) MAGL (1) MAP3K (2) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitophagy (1) MMP (1) Monoamine Oxidase (1) mTOR (2) MyD88 (1) Na+/H+ Exchanger (NHE) (1) nAChR (1) NADPH Oxidase (1) NF-κB (69) NO Synthase (41) NOD-like Receptor (NLR) (13) P2Y Receptor (2) p38 MAPK (30) Parasite (7) PGE synthase (3) Phosphatase (2) Phosphodiesterase (PDE) (8) Phospholipase (1) PI3K (5) PKC (1) Potassium Channel (2) PPAR (2) Prostaglandin Receptor (2) PROTACs (1) Proton Pump (2) PTEN (1) Pyroptosis (2) Pyruvate Kinase (2) Ras (1) Reactive Oxygen Species (13) Ser/Thr Protease (1) Sirtuin (2) Sodium Channel (3) STAT (4) STING (1) Tau Protein (1) Thyroid Hormone Receptor (1) TNF Receptor (27) Toll-like Receptor (TLR) (16) Topoisomerase (3) Xanthine Oxidase (1) YB-1 (1)
By Research Areas:	Cancer (50) Cardiovascular Disease (14) Endocrinology (4) Infection (42) Inflammation/Immunology (293) Metabolic Disease (17) Neurological Disease (38)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 Maximum Cited Publications 161 Publications Verification LPS, from Escherichia coli (O55:B5)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

HY-119487

MMPP

STAT Inflammation/Immunology

MMPP is an anti-inflammatory agent. MMPP prevents LPS-induced mortality by inhibiting the inflammatory response via STAT3 activity inhibition .
HY-135164

Lonchocarpic acid

Others Inflammation/Immunology

Lonchocarpic acid has an anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation .
HY-112456

IKK2-IN-4

IKK Inflammation/Immunology

IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC₅₀ of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs .
HY-N2053

Physalin L

NO Synthase Endogenous Metabolite

Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity .

MMPP	STAT	Inflammation/Immunology
MMPP is an anti-inflammatory agent. MMPP prevents LPS-induced mortality by inhibiting the inflammatory response via STAT3 activity inhibition .

Lonchocarpic acid	Others	Inflammation/Immunology
Lonchocarpic acid has an anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation .

IKK2-IN-4	IKK	Inflammation/Immunology
IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC₅₀ of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs .

Physalin L	NO Synthase Endogenous Metabolite
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity .

HY-N8759

Vogeloside	Others	Inflammation/Immunology
Vogeloside is an iridoid that can be isolated from the roots of Triosteum pinnatifidum. Vogeloside inhibits nitric oxide production in LPS-activated macrophages .

HY-117601

11-Deoxyalisol B	Others	Inflammation/Immunology
11-Deoxyalisol B, a triterpene, shows the potent inhibitory activity on Lipopolysaccharide (LPS)-induced nitric oxide (NO) production .

HY-N2968

Bullatantriol (+)-Bullatantriol	Others	Inflammation/Immunology
Bullatantriol ((+)?-?Bullatantriol) can be isolated from the roots of Homalomena aromatica. Bullatantriol can promote the proliferation and differentiation of osteoblasts. Bullatantriol also inhibits LPS-induced NO production in BV2 cells .

HY-N12069

Praeroside IV	Others	Inflammation/Immunology
Praeroside IV can be isolated from the roots of Angelica furcijuga. Praeroside IV can be used for research of D-GalN/LPS-induced liver injury .

HY-P1439

RS 09 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
RS09 is a LPS peptide mimic serves as a candidate to be considered as a new class of TLR4 agonist adjuvant. RS09 increases antibody production in a vaccine setting .

HY-N3245

Moracin C 1 Publications Verification	Reactive Oxygen Species COX	Inflammation/Immunology
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells .

HY-N3006

Sakuranetin 1 Publications Verification	Fungal	Infection Inflammation/Immunology
Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity . Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury .

HY-N10386

Dichotomine B

Others Inflammation/Immunology

Dichotomine B, a β-Carboline alkaloid, attenuates neuroinflammatory responses in LPS/ATP-induced BV2 microglia .

Dichotomine B	Others	Inflammation/Immunology
Dichotomine B, a β-Carboline alkaloid, attenuates neuroinflammatory responses in LPS/ATP-induced BV2 microglia .

HY-N8444

Triptoquinone A	Interleukin Related	Cardiovascular Disease
Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .

HY-148553

Anti-inflammatory agent 36	Others	Inflammation/Immunology
Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation .

HY-N1494

(+)-14-Deoxy-ε-caesalpin 14-Deoxy-ε-caesalpin	NO Synthase	Inflammation/Immunology
(+)-14-Deoxy-ε-caesalpin (14-Deoxy-ε-caesalpin), a cassane diterpenoid, inhibits nitric oxide (NO) production release of RAW 264.7 cells stimulated by Lipopolysaccharide (LPS) .

HY-151399

Antimicrobial agent-5	Bacterial	Infection
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation .

HY-N10175

Berkeleyacetal C	Fungal Endogenous Metabolite	Inflammation/Immunology
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways .

HY-N0857

Deoxyandrographolide 1 Publications Verification	Interleukin Related	Neurological Disease Inflammation/Immunology
Deoxyandrographolide suppresses LPS induced increase in mRNA levels of iNOS as well as production of proinflammatory mediators TNF-α and IL-6. Deoxyandrographolide potentiates NGF-induced neurite outgrowth .

HY-115927

8A8	NO Synthase	Inflammation/Immunology
8A8 is a potent proinflammatory factor NO inhibitor with an IC₅₀ of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation .

HY-149816

Anti-inflammatory agent 41	Interleukin Related TNF Receptor NF-κB	Inflammation/Immunology
Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines IL-6 and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway .

HY-N1713

29-Nor-20-oxolupeol	Others	Neurological Disease
29-Nor-20-oxolupeol, extracted from Impatiens basamina, reduces NO levels in LPS-activated murine microglial cells with an IC₅₀ of 44.21 µM .

HY-P99214

Panobacumab KBPA101	Bacterial	Infection
Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody generated by immortalizing human B lymphocytes against the LPS O polysaccharide of serotype O11 of *P. aeruginosa* .

HY-153762

COX-2-IN-32	NO Synthase NF-κB COX	Inflammation/Immunology
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC₅₀: 11.2 μM) .

HY-146974

PDE4-IN-9	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC₅₀ value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS .

HY-120041

ND-2158	IRAK	Cancer
ND-2158 is a competitive IRAK4 inhibitor, with the K_i of 1.3 nM. ND-2158 suppresses LPS-induced TNF production in human white blood cells, alleviated collagen-induced arthritis, and blocked gout formation in mouse models. ND-2158 has antitumor activity in vivo .

HY-146167

iNOS/PGE2-IN-1	NO Synthase	Inflammation/Immunology
iNOS/PGE2-IN-1 (compound 4a), an iNOS/PGE2 inhibitor, is a potent anti-inflammatory agent. iNOS/PGE2-IN-1 can inhibit LPS-induced NO production. iNOS/PGE2-IN-1 possesses low ulcerogenic liabilities .

HY-W670564A

(4S)-10-Nor-calamenen-10-one	Others	Neurological Disease
(4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla .

HY-125495

Telmesteine	Others	Inflammation/Immunology
Telmesteine is an amucolitic agent. Telmesteine has anti-protease activity. Telmesteine inhibits LPS-induced NO production in RAW264.7 cells. Telmesteine can be used for research of inflammation, such as acute and chronic bronchitis and obstructive airways disease .

HY-N9000

Loganic acid 6′-O-β-D-glucoside	TNF Receptor	Inflammation/Immunology
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .

HY-123542

ONO-3403	Ser/Thr Protease Apoptosis	Cancer
ONO-3403 is an orally active serine protease inhibitor. ONO-3403 inhibits the production of TNF-α and nitric oxide induced by *LPS. ONO-3403 inhibits the cell growth and induces the apoptosis*, and has an antitumor effect on malignant tumors .

HY-N4061

Hedycoronen A	Interleukin Related	Inflammation/Immunology
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-162316

NF-κB-IN-15	NF-κB	Inflammation/Immunology
NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI) .

HY-156060

NCI126224	Toll-like Receptor (TLR)	Inflammation/Immunology
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases .

HY-B0516A

Articaine Hoe-045 free base	NF-κB NOD-like Receptor (NLR) Sodium Channel	Inflammation/Immunology
Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway .

HY-N0613

Sauchinone 1 Publications Verification	NF-κB	Inflammation/Immunology
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-139374

Zabedosertib 1 Publications Verification BAY 1834845	IRAK	Inflammation/Immunology
Zabedosertib (BAY 1834845) is a selective, orally active IRAK4 inhibitor with immunomodulatory potential, IC₅₀ is 3.55 nM. IRAK4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors . Zabedosertib exhibits anti-inflammatory property against IL-β, LPS (HY-D1056) and Imiquimod (HY-B1080) induced inflammation .

HY-32018

Cot inhibitor-2 2 Publications Verification	MAP3K	Cancer
Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC₅₀ of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC₅₀ of 0.3 μM .

HY-B0516

Articaine hydrochloride Hoe-045	Sodium Channel NF-κB NOD-like Receptor (NLR)	Neurological Disease
Articaine hydrochloride (Hoe-045) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine hydrochloride ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway .

HY-149248

NF-κB-IN-8	NF-κB	Inflammation/Immunology
NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. NF-κB-IN-8 reduces the expression of inflammatory factors by binding to MD-2. NF-κB-IN-8 also inhibits ALP activity. NF-κB-IN-8 can be used for the research of inflammation such as acute lung injury (ALI) .

HY-12085

Apremilast 5+ Cited Publications CC-10004	Phosphodiesterase (PDE) Apoptosis TNF Receptor	Inflammation/Immunology
Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-D1594

BODIPY TR Cadaverine	Fluorescent Dye	Others
BODIPY TR Cadaverine, a cadaverine derivative, is a red fluorescent dye. BODIPY TR Cadaverine can be used in a a highly sensitive and robust fluorescent displacement assay, which binds to native LPS strongly, specifically recognizing lipid A, and is competitively displaced by compounds displaying an affinity for lipid A .

HY-149179

Polymyxin B 2 Publications Verification	Bacterial Antibiotic	Infection
Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research .

HY-150732

IRAK4-IN-18	IRAK	Inflammation/Immunology
IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease .

HY-150733

IRAK4-IN-19	IRAK	Inflammation/Immunology
IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease .

HY-N0997

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one	NO Synthase	Inflammation/Immunology Cancer
(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one (compound7) is a nature product isolated from rhizomes of Curcuma kwangsiensis. (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one has inhibitory effect on NO production induced by LPS in macrophages with an IC₅₀ value of 8.93 μM .

HY-124151

Adenosine-2'-monophosphate 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation .

HY-12085S

Apremilast-d5 CC-10004-d₅	Phosphodiesterase (PDE) TNF Receptor Apoptosis	Inflammation/Immunology
Apremilast-d₅ is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

HY-152213

BET-IN-13	Epigenetic Reader Domain	Inflammation/Immunology
BET-IN-13 is a potent BET inhibitor with an IC₅₀ value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury .

HY-126390

(E/Z)-BCI NSC 150117	Phosphatase Apoptosis	Inflammation/Immunology Cancer
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .

Cat. No.	Product Name	Type

HY-D1594

BODIPY TR Cadaverine	Fluorescent Dyes/Probes
BODIPY TR Cadaverine, a cadaverine derivative, is a red fluorescent dye. BODIPY TR Cadaverine can be used in a a highly sensitive and robust fluorescent displacement assay, which binds to native LPS strongly, specifically recognizing lipid A, and is competitively displaced by compounds displaying an affinity for lipid A .

HY-D0249

Sunset Yellow FCF 1 Publications Verification Orange Yellow S; Food Yellow 3; CI 15985	Dyes
Sunset Yellow FCF (Orange Yellow S) is an orange azo dye with a maximum absorption wavelength of 480 nm. Sunset Yellow FCF can be used in food, cosmetics and pharmaceuticals .

Cat. No.	Product Name	Type

HY-D1056

Lipopolysaccharides, from E. coli O55:B5

160+ Cited Publications

LPS, from Escherichia coli (O55:B5)

Biochemical Assay Reagents

Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

HY-P3466

Nisin Z

Biochemical Assay Reagents

Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans .

HY-144012A

16:0 PEG350 PE

DPPE-PEG350; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] ammonium

Drug Delivery

16:0 PEG350 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144012B

16:0 PEG550 PE

DPPE-PEG550; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-550] ammonium

Drug Delivery

16:0 PEG550 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144012C

16:0 PEG750 PE

DPPE-PEG750; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-750] ammonium

Drug Delivery

16:0 PEG750 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144013A

18:0 mPEG350 PE ammonium

DSPE-mPEG350 ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] ammonium

Drug Delivery

18:0 mPEG350 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144013B

18:0 mPEG550 PE ammonium

DSPE-mPEG550 ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-550] ammonium

Drug Delivery

18:0 mPEG550 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144013C

18:0 mPEG750 PE ammonium

DSPE-mPEG750 ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-750] ammonium

Drug Delivery

18:0 mPEG750 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144012D

16:0 PEG1000 PE

DPPE-PEG1000; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] ammonium

Drug Delivery

16:0 PEG1000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144012E

16:0 PEG3000 PE

DPPE-PEG3000; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000] ammonium

Drug Delivery

16:0 PEG3000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144012H

16:0 PEG5000 PE

DPPE-PEG5000; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium

Drug Delivery

16:0 PEG5000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144013D

18:0 mPEG1000 PE ammonium

DSPE-mPEG1000 ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] ammonium

Drug Delivery

18:0 mPEG1000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144013E

18:0 mPEG3000 PE ammonium

DSPE-mPEG3000 ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000] ammonium

Drug Delivery

18:0 mPEG3000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-144013H

18:0 mPEG5000 PE ammonium

DSPE-mPEG5000 ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium

Drug Delivery

18:0 mPEG5000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155924

14:0 PEG350 PE

DMPE-PEG350; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] ammonium

Drug Delivery

14:0 PEG350 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155925

14:0 PEG550 PE

DMPE-PEG550; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-550] ammonium

Drug Delivery

14:0 PEG550 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155926

14:0 PEG750 PE

DMPE-PEG750; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-750] ammonium

Drug Delivery

14:0 PEG750 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155927

14:0 PEG1000 PE

DMPE-PEG1000; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] ammonium

Drug Delivery

14:0 PEG1000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155928

14:0 PEG3000 PE

DMPE-PEG3000; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000] ammonium

Drug Delivery

14:0 PEG3000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155929

14:0 PEG5000 PE

DMPE-PEG5000; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium

Drug Delivery

14:0 PEG5000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155930

18:1 PEG350 PE

DOPE-PEG350; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] ammonium

Drug Delivery

18:1 PEG350 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155931

18:1 PEG550 PE

DOPE-PEG550; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-550] ammonium

Drug Delivery

18:1 PEG550 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155932

18:1 PEG1000 PE

DOPE-PEG1000; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] ammonium

Drug Delivery

18:1 PEG1000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155933

18:1 PEG3000 PE

DOPE-PEG3000; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000] ammonium

Drug Delivery

18:1 PEG3000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-155934

18:1 PEG5000 PE

DOPE-PEG5000; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium

Drug Delivery

18:1 PEG5000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-113058

3-Hydroxyoctanoic acid

Biochemical Assay Reagents

3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.

HY-P1956

Human serum albumin

HSA

Native Proteins

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

Cat. No.	Product Name	Target	Research Area

HY-P3912A

Endotoxin inhibitor TFA	Peptides	Infection
Endotoxin inhibitor TFA is a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor TFA inhibits the febrile response to LPS with very low toxicity and lethality .

HY-P1439

RS 09 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
RS09 is a LPS peptide mimic serves as a candidate to be considered as a new class of TLR4 agonist adjuvant. RS09 increases antibody production in a vaccine setting .

HY-P3496

Pep19-2.5	Pyroptosis	Inflammation/Immunology
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .

HY-P3912

Endotoxin inhibitor	Peptides	Infection
Endotoxin inhibitor a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor inhibits the febrile response to LPS with very low toxicity and lethality .

HY-P10178

Myristoylated ARF6 (2-13)

Peptides Inflammation/Immunology

Myristoylated ARF6 (2-13) blocks MyD88–ARNO–ARF6–signaling axis by deactivating ARF6 .

HY-P5838

Citrullinated LL-37 5cit	Peptides	Inflammation/Immunology
Citrullinated LL-37 5cit is a citrullinated LL-37 (HY-P1222) peptide. The antiviral and antibacterial effects of Citrullinated LL-37 5cit are significantly reduced compared to native LL-37. Citrullinated LL-37 5cit is unable to reduce LPS-mediated release of TNF-α due to a lack of LPS-binding capacity .

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-P10354

SPA4

Interleukin Related Inflammation/Immunology

SPA4 is a TLR4-interacting peptide. SPA4 inhibits the LPS-induced TNF-α cytokine response without effect the cell viability or size .

HY-P2280

TAT-P110	Dynamin	Neurological Disease Inflammation/Immunology
TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 .

HY-P5680

SpHistin	Bacterial	Inflammation/Immunology
SpHistin is an antimicrobial peptide (AMP). SpHistin can bind to LPS (HY-D1056) and permeabilize the bacterial membrane. SpHistin combined with Rifampicin (HY-B0272) and Azithromycin (HY-17506) promotes the intracellular uptake of the antibiotics and subsequently enhances the bactericidal activity of both agents against P. aeruginosa .

HY-P3466

Nisin Z	Bacterial Fungal	Infection Inflammation/Immunology
Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans .

HY-106216

Tiprelestat	Elastase	Infection Inflammation/Immunology
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-P1098B

Ac2-26 ammonium 3 Publications Verification	IKK	Inflammation/Immunology
Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .

HY-P1791

Lactoferrin (17-41) Lactoferricin B; Lfcin B	Bacterial Fungal Apoptosis	Infection Cancer
Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities .

HY-P1791B

Lactoferrin (17-41) (acetate) Lactoferricin B acetate; Lfcin B acetate	Bacterial Fungal Apoptosis	Infection Cancer
Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities .

Cat. No.	Product Name

HY-K1044

Polymyxin B (1,000×), Sterile

Polymixin B is a mixture of B1 and B2 polypeptides obtained from different strains of Bacillus polymyxa, with antibacterial activity against gram-negative bacteria. It can bind lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria and disrupts the cytoplasmic membrane by inducing large pores to allow nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Cat. No.	Product Name	Target	Research Area

HY-P99214

Panobacumab KBPA101	Bacterial	Infection
Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody generated by immortalizing human B lymphocytes against the LPS O polysaccharide of serotype O11 of *P. aeruginosa* .

HY-P99008

Atibuclimab 1 Publications Verification	Inhibitory Antibodies	Inflammation/Immunology
Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis . Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 Maximum Cited Publications 161 Publications Verification LPS, from Escherichia coli (O55:B5)	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	Toll-like Receptor (TLR)
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

HY-135164

Lonchocarpic acid	Structural Classification Leguminosae Derris scandens Source classification Coumarins Phenylpropanoids Plants	Others
Lonchocarpic acid has an anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation .

HY-N2053

Physalin L	Structural Classification Natural Products Physalis minima Linn. Source classification Plants Solanaceae	NO Synthase Endogenous Metabolite
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity .

HY-N8759

Vogeloside	Structural Classification Caprifoliaceae Triosteum pinnatifidum Maxim. Source classification Plants Saccharides Monosaccharides	Others
Vogeloside is an iridoid that can be isolated from the roots of Triosteum pinnatifidum. Vogeloside inhibits nitric oxide production in LPS-activated macrophages .

HY-N2968

Bullatantriol (+)-Bullatantriol	Structural Classification Natural Products Araceae Source classification Homalomena aromatica Gagnep. Plants	Others
Bullatantriol ((+)?-?Bullatantriol) can be isolated from the roots of Homalomena aromatica. Bullatantriol can promote the proliferation and differentiation of osteoblasts. Bullatantriol also inhibits LPS-induced NO production in BV2 cells .

HY-N12069

Praeroside IV	Structural Classification Angelica furcijuga Kitag. Source classification Coumarins Phenylpropanoids Plants Umbelliferae	Others
Praeroside IV can be isolated from the roots of Angelica furcijuga. Praeroside IV can be used for research of D-GalN/LPS-induced liver injury .

HY-N3245

Moracin C 1 Publications Verification	Structural Classification Source classification Phenols Polyphenols Plants Moraceae	Reactive Oxygen Species COX
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells .

HY-N3006

Sakuranetin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cerasus cerasoides Rosaceae Plants Inflammation/Immunology Disease Research Fields	Fungal
Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity . Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury .

HY-N8444

Triptoquinone A	Quinones Structural Classification Source classification Celastraceae Plants Tripterygium wilfordii Hook. f. Naphthalene Quinones	Interleukin Related
Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .

HY-N10175

Berkeleyacetal C	Other Terpenoids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Fungal Endogenous Metabolite
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways .

HY-N0857

Deoxyandrographolide 1 Publications Verification	Andrographis paniculata (Burm. F.) Nees Acanthaceae Terpenoids Source classification Diterpenoids Plants	Interleukin Related
Deoxyandrographolide suppresses LPS induced increase in mRNA levels of iNOS as well as production of proinflammatory mediators TNF-α and IL-6. Deoxyandrographolide potentiates NGF-induced neurite outgrowth .

HY-N1713

29-Nor-20-oxolupeol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Plants Inflammation/Immunology Disease Research Fields Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
29-Nor-20-oxolupeol, extracted from Impatiens basamina, reduces NO levels in LPS-activated murine microglial cells with an IC₅₀ of 44.21 µM .

HY-W670564A

(4S)-10-Nor-calamenen-10-one	Structural Classification Natural Products Source classification Plants Alpinia oxyphylla Miq. Zingiberaceae	Others
(4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla .

HY-N9000

Loganic acid 6′-O-β-D-glucoside	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Gentianaceae Plants Inflammation/Immunology Disease Research Fields Gentiana rhodantha Franch. ex Hemsl.	TNF Receptor
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .

HY-N4061

Hedycoronen A	Hedychium coronarium Koen. Structural Classification Terpenoids Source classification Diterpenoids Plants Zingiberaceae	Interleukin Related
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-N0613

Sauchinone 1 Publications Verification	Saururaceae Classification of Application Fields Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology	NF-κB
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N0997

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one	Structural Classification Classification of Application Fields Source classification Phenols Curcuma kwangsiensis S. K. Lee & C. F. Liang Plants Inflammation/Immunology Disease Research Fields Cancer Zingiberaceae	NO Synthase
(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one (compound7) is a nature product isolated from rhizomes of Curcuma kwangsiensis. (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one has inhibitory effect on NO production induced by LPS in macrophages with an IC₅₀ value of 8.93 μM .

HY-124151

Adenosine-2'-monophosphate 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate	Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Adenosine Receptor Endogenous Metabolite
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation .

HY-N3548

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-129143

Delphinidin-3-sambubioside chloride Dp3‐Sam chloride	Malvaceae Structural Classification Flavonoids Hibiscus sabdariffa Linn. Plants Other Flavonoids	Others
Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L. .

HY-N0373

Licochalcone B 4 Publications Verification	Chalcones Flavonoids Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Amyloid-β Apoptosis NOD-like Receptor (NLR)
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

HY-N10768

1-Dehydro-[10]-gingerdione	Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-N1546

Protoplumericin A	Apocynaceae Structural Classification Polysaccharides Allamanda schottii Source classification Plants Saccharides	Others
Protoplumericin A is a bioactive ingredient of Plumeria obtusa L. attenuates. Protoplumericin A mitigated lipopolysaccharide (LPS) -induced acute lung injury in mice. Protoplumericin A can be used to study the LPS-induced anti-inflammatory effect .

HY-N0625A

Alpinetin 3 Publications Verification	Structural Classification Alpinia katsumadai Hayata Classification of Application Fields Source classification Plants Monophenols Flavonoids Flavonones Phenols Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	PPAR
Alpinetin is a flavonoid isolated from cardamom and has anti-inflammatory activity. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury .

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Toll-like Receptor (TLR) TNF Receptor
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2 .

HY-N10120

Methylsyringin	Classification of Application Fields Simple Phenylpropanols Carthamus tinctorius L. Source classification Phenylpropanoids Plants Compositae Disease Research Fields Inflammation/Immunology	Others
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

HY-N1330

Rubranol	Structural Classification Source classification Phenols Polyphenols Alnus formosana (Burkill) Makino Plants Betulaceae	NO Synthase
Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition .

HY-N1317

Salirepin	Monophenols Source classification Melia azedarach L. Phenols Plants Meliaceae	Others
Salirepin is a phenolic glycoside from fruits of Idesia polycarpa, inhibits LPS-induced nitric oxide production .

HY-N3392

Lethedoside A	Structural Classification Flavonoids Flavones Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	NO Synthase
Lethedoside A is a natural flavonoid that shows inhibitory activity for LPS-induced NO production in RAW 264.7 cells .

HY-N8427

Bisacurone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Zingiberaceae	NO Synthase
Bisacurone is a natural terpenoid, exhibits inhibitory activities on LPS-induced NO production with an IC₅₀ of 29.8 μM .

HY-N3480

Isogosferol (+)-Isogospherol; Isogospherol	Structural Classification Source classification Coumarins Phenylpropanoids Callicarpa dichotoma (Lour.) K. Koch Plants Umbelliferae	Others
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 .

HY-N12042

Taxamairin B	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus wallichiana var. mairei (Lemee & H. Léveillé) L. K. Fu & Nan Li	TNF Receptor PI3K Reactive Oxygen Species Interleukin Related
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-N2620

Rutaevin	Other Terpenoids Classification of Application Fields Terpenoids Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species
Rutaevin is isolated from the fruits of Euodia rutaecarpa. Rutaevin inhibits NO production in LPS-induced RAW 264.7 macrophages .

HY-N7018

20-Hydroxyganoderic Acid G	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Inflammation/Immunology Disease Research Fields	Others
20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC₅₀ of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the agent discovery of nerve inflammation diseases associated with microglia activated by LPS .

HY-N10114

Hyperectumine	Alkaloids Classification of Application Fields Source classification Hypecoum erectum L. Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Papaveraceae	Others
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N1380

Guaiacol 2-Methoxyphenol	Human Gut Microbiota Metabolites Monophenols other families Microorganisms Classification of Application Fields Source classification Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX NF-κB Endogenous Metabolite
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	Caprifoliaceae Classification of Application Fields Lonicera japonica Thunb. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology	TNF Receptor Interleukin Related
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-N7697C

Chitohexaose hexahydrochloride	Classification of Application Fields Animals Source classification Disease Research Fields Inflammation/Immunology Saccharides	Toll-like Receptor (TLR)
Chitohexaose hexahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitohexaose hexahydrochloride binds to the active sites of TLR4 and inhibits LPS induced inflammation .

HY-N10111

Siegesbeckialide I	Classification of Application Fields Terpenoids Pterocarpus macrocarpus Kurz Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	IKK
Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.

HY-N10119

Ganoderterpene A	Triterpenes Terpenoids Source classification Polyporaceae Plants	p38 MAPK
Ganoderterpene A attenuates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells.

HY-N1531

Randaiol Magnotriol A	Structural Classification Magnolia officinalis. Rehd. et Wils. Magnoliaceae Source classification Phenols Polyphenols Plants	NO Synthase
Randaiol is an antioxidant that can be isolated from the stem bark of Magnolia officinalis. Randaiol inhibits LPS-induced NO production and has anti-inflammatory and antioxidant activities .

HY-N3473

Isomaculosidine	Alkaloids Dictamnus dasycarpus Turcz. Source classification Rutaceae Quinoline Alkaloids Plants	NO Synthase
Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .

HY-N8631

O-Acetylschisantherin L Acetylschisantherin L	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	NO Synthase
O-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan, which exhibits inhibitory effects on LPS-induced NO production in BV-2 cells with an IC₅₀ of 23.1 μM .

HY-133098

Juncutol	Juncaceae Source classification Plants Juncus acutus L.	NO Synthase
Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .

HY-N9896

Anhydronotoptol	Structural Classification Natural Products Isodon excisoides (Sun ex C. H. Hu) H. Hara Source classification Plants Umbelliferae	NO Synthase
Anhydronotoptol is a potent nitric oxide inhibitory coumarin. Anhydronotoptol inhibits NO production in RAW 264.7 cells induced by LPS with an IC₅₀ value of 36.6 μM .

HY-N4136

Lonicerin	Infection Structural Classification Flavonoids Caprifoliaceae Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields	Bacterial Apoptosis Endogenous Metabolite
Lonicerin is an anti-algE (alginate secretion protein) flavonoid with inhibitory activity for P. aeruginosa. Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury .

HY-N12521

(3β,24S)-3-Hydroxystigmast-5-en-7-one	Triterpenes Structural Classification Terpenoids Source classification Plants Lauraceae Lindera akoensis Hay.	Others
(3β,24S)-3-Hydroxystigmast-5-en-7-one (Compound 31) is a compound that can be isolated from Lindera akoensis . (3β,24S)-3-Hydroxystigmast-5-en-7-one has anti-inflammatory activity .

HY-N6673

Okanin 1 Publications Verification	Cardiovascular Disease Chalcones Flavonoids Neurological Disease Classification of Application Fields Cercis chinensis Bunge Source classification Phenols Polyphenols Plants Compositae Disease Research Fields	Toll-like Receptor (TLR) NF-κB
Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways .

HY-N2270

Chicanine	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields	p38 MAPK ERK IKK
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .

HY-N10275

Herpotrichone A	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Others
Herpotrichone A shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC₅₀) value of 0.41 μM.

Cat. No.	Compare	Product Name	Species	Source

HY-P702258

	CXCR4-VLPs Protein, Human (HEK293, His) CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184	Human	HEK293
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4-VLPs Protein, Human (HEK293, His) is the recombinant human-derived CXCR4-VLPs protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CXCR4-VLPs Protein, Human (HEK293, His) is 352 a.a., with molecular weight of 41.5 kDa.

Cat. No.	Product Name	Chemical Structure

HY-12085S

Apremilast-d5
Apremilast-d₅ is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

HY-N1380S1

Guaiacol-d3
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

HY-N1380S

Guaiacol-d7
Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S3

Guaiacol-d4
Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S2

Guaiacol-13C6
Guaiacol- ¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S4

Guaiacol-d4-1
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-B0289S

Erdosteine-13C4
Erdosteine- ¹³C₄ is a ¹³C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].

HY-13571AS1

Beclometasone dipropionate-d10
Beclometasone dipropionate-d₁₀ is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-13571AS

Beclometasone dipropionate-d6
Beclometasone dipropionate-d₆ is deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-B0335S

Tolfenamic Acid-D4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82917

IRF6 Antibody (YA2662)

Interferon regulatory factor 6; IRF 6; LPS; OFC 6; PIT; PPS; PPS1; VWS; VWS1
WB, IHC-P, ICC/IF Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-133870

Itaconate-alkyne 1 Publications Verification ITalk		Alkynes
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate . Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

LPS

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products