2. Academic Validation
  3. Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp

Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp

  • J Nat Prod. 2004 Dec;67(12):2090-2. doi: 10.1021/np030326w.
Yunjiang Feng 1,  John W Blunt,  Anthony L J Cole,  Murray H G Munro
Affiliations

Affiliation

  • 1 Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
PMID: 15620259 DOI: 10.1021/np030326w
Abstract

Three novel thiodiketopiperazine derivatives, T988 A, B, and C (1-3), were isolated from a Tilachlidium sp. Their structures were elucidated by spectroscopic analyses using various 1D and 2D NMR techniques. All the compounds showed potent cytotoxicity against cultured P388 leukemia cells.

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