Search Result

Results for "

β3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) AAK1 (1) Adenosine Receptor (3) Adrenergic Receptor (45) Amyloid-β (2) Antibiotic (1) Apoptosis (11) Aryl Hydrocarbon Receptor (1) Autophagy (7) Beta-secretase (1) c-Myc (1) Calcium Channel (3) CDK (19) CFTR (1) Cholinesterase (ChE) (3) CRISPR/Cas9 (1) DYRK (2) Endogenous Metabolite (2) ERK (2) Estrogen Receptor/ERR (5) GABA Receptor (19) GSK-3 (60) HIV (1) HSV (2) Integrin (42) Isotope-Labeled Compounds (6) JAK (2) JNK (1) Lipoxygenase (1) mAChR (1) MEK (2) Microtubule/Tubulin (1) nAChR (5) Parasite (3) PGC-1α (1) Pim (1) PKA (1) PKC (2) PROTACs (1) Proton Pump (2) RANKL/RANK (1) Renin (3) ROS Kinase (1) STAT (1) Tau Protein (3) TGF-β Receptor (1) β-catenin (1)
By Research Areas:	Cancer (64) Cardiovascular Disease (22) Endocrinology (26) Infection (5) Inflammation/Immunology (32) Metabolic Disease (32) Neurological Disease (62)

By Targets:

5-HT Receptor (4)

AAK1 (1)

Adenosine Receptor (3)

Adrenergic Receptor (45)

Amyloid-β (2)

Antibiotic (1)

Apoptosis (11)

Aryl Hydrocarbon Receptor (1)

Autophagy (7)

Beta-secretase (1)

c-Myc (1)

Calcium Channel (3)

CDK (19)

CFTR (1)

Cholinesterase (ChE) (3)

CRISPR/Cas9 (1)

DYRK (2)

Endogenous Metabolite (2)

ERK (2)

Estrogen Receptor/ERR (5)

GABA Receptor (19)

GSK-3 (60)

HIV (1)

HSV (2)

Integrin (42)

Isotope-Labeled Compounds (6)

JAK (2)

JNK (1)

Lipoxygenase (1)

mAChR (1)

MEK (2)

Microtubule/Tubulin (1)

nAChR (5)

Parasite (3)

PGC-1α (1)

Pim (1)

PKA (1)

PKC (2)

PROTACs (1)

Proton Pump (2)

RANKL/RANK (1)

Renin (3)

ROS Kinase (1)

STAT (1)

Tau Protein (3)

TGF-β Receptor (1)

β-catenin (1)

By Research Areas:

Cancer (64)

Cardiovascular Disease (22)

Endocrinology (26)

Infection (5)

Inflammation/Immunology (32)

Metabolic Disease (32)

Neurological Disease (62)

196

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

SR59230A 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .

SR59230A hydrochloride 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .

β3-AR agonist 2	Adrenergic Receptor	Metabolic Disease Endocrinology
β₃-AR agonist 2 is a potent and selective β₃-adrenergic receptor (β₃-AR) agonist with an EC₅₀ of 8 nM.

β3-AR agonist 1	Adrenergic Receptor	Cardiovascular Disease Endocrinology
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC₅₀=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold) .

β3-AR agonist 3	Adrenergic Receptor	Inflammation/Immunology
β3-AR agonist 3 is a potent beta-3 adrenoreceptor agonist. β3-AR agonist 3 has the potential for prostatitis research .

(2R)-SR59230A	Others	Cardiovascular Disease Metabolic Disease
(2R)-SR59230A is the isomer of SR59230A (HY-100672), and can be used as an experimental control. SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .

Talibegron hydrochloride ZD2079 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Talibegron hydrochloride (ZD2079 hydrochloride) is a potent *β3-adrenoceptor* agonist with a pD₂ of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect .

Valerenic acid 1 Publications Verification (-)-Valerenic Acid	GABA Receptor 5-HT Receptor	Neurological Disease
Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABA_A receptors. Valerenic acid is also a partial agonist of the 5-HT_5a receptor. Valerenic acid mediates anxiolytic activity via GABA_A receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties ^[3].

Vemtoberant APD418	Adrenergic Receptor	Endocrinology
Vemtoberant is an β₃ Adrenergic Receptor antagonist. Vemtoberant can be used for research of β₃ adrenergic receptor-mediated disorder, such as, heart failure .

Vemtoberant mesylate APD418 mesylate	Adrenergic Receptor	Endocrinology
Vemtoberant mesylate is an β₃ Adrenergic Receptor antagonist. Vemtoberant mesylate can be used for research of β₃ adrenergic receptor-mediated disorder, such as, heart failure .

SB-267268	Integrin	Cancer
SB-267268 is a selective and nonpeptidic alpha(v)beta3 (αvβ3) and alpha(v)beta5 (αvβ5) integrins antagonist, with K_is of 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respectively. SB-267268 inhibits human and mouse αvβ3 with IC₅₀s of 0.68 and 0.29 nM, respectively. SB-267268 reduces angiogenesis and VEGF expression .

Mirabegron 4 Publications Verification YM178	Adrenergic Receptor	Neurological Disease Endocrinology
Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

SB-206606	Adrenergic Receptor	Cardiovascular Disease
SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β₃-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β₃-AR than for the beta 1/beta 2-adrenergic receptors .

Cyclo(-RGDfK) 5+ Cited Publications	Integrin	Cancer
Cyclo(-RGDfK) is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

Solabegron 1 Publications Verification GW 427353	Adrenergic Receptor	Metabolic Disease Endocrinology
Solabegron (GW 427353) is a selective β₃-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM . Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .

Cyclo(-RGDfK) TFA 5+ Cited Publications	Integrin	Cancer
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface ^[3].

Cyclo(RGDyK) trifluoroacetate 3 Publications Verification	Integrin	Cancer
Cyclo(RGDyK) trifluoroacetate is a potent and selective α_Vβ₃ integrin inhibitor with an IC₅₀ of 20 nM.

Cyclo(RGDyK) 3 Publications Verification	Integrin	Cancer
Cyclo(RGDyK) is a potent and selective α_Vβ₃ integrin inhibitor with an IC₅₀ of 20 nM.

Echistatin	Integrin	Metabolic Disease Inflammation/Immunology
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ ^[3] .

Echistatin TFA	Integrin	Metabolic Disease Inflammation/Immunology
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ ^[3] .

Amibegron hydrochloride SR 58611A	Adrenergic Receptor	Neurological Disease Endocrinology
Amibegron hydrochloride is a selective *β3-adrenoceptor* agonist, with an EC₅₀ of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.

LXW7	Integrin	Inflammation/Immunology
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect ^[3].

BRL 37344 sodium BRL 37344A	Adrenergic Receptor	Metabolic Disease Endocrinology
BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice .

(Rac)-Mirabegron-d5 (Rac)-YM178-d₅	Isotope-Labeled Compounds Adenosine Receptor	Metabolic Disease
(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist[1].

HSDVHK-NH2	Integrin	Cancer
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

Integrin Antagonists 27	Integrin	Cancer
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.

LXW7 TFA	Integrin	Inflammation/Immunology
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect ^[3].

Loreclezole R 72063	GABA Receptor	Neurological Disease
Loreclezole, an antiepileptic compound, is a selective GABA_A receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors .

Loreclezole hydrochloride R 72063 hydrochloride	GABA Receptor	Neurological Disease
Loreclezole hydrochloride, an antiepileptic compound, is a selective GABA_A receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors .

HSDVHK-NH2 TFA	Integrin	Cancer
HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

Cilengitide TFA Maximum Cited Publications 39 Publications Verification EMD 121974 TFA	Integrin Autophagy	Cancer
Cilengitide is a potent and selective integrin inhibitor for α_vβ₃ and α_vβ₅ receptor, with IC₅₀ values of 4 nM and 79 nM, respectively.

CGP 12177 hydrochloride (±)-CGP 12177 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
CGP 12177 ((±)-CGP 12177) hydrochloride is a β Adrenergic Receptor Ligand. CGP 12177 hydrochloride is a high affinity antagonist of β1- and β2-AR. CGP 12177 hydrochloride is also shown to interact, with a lower affinity, with the β3-AR and to exhibit a partial agonist activity on rodent and human β3-AR. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery .

KUC-7322	Adrenergic Receptor	Metabolic Disease Endocrinology
KUC-7322, a selective β3 -adrenoceptor agonist, is the active form of ritobegron. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.

LY377604	Adrenergic Receptor	Metabolic Disease Endocrinology
LY377604 is a *human β₃-adrenergic* receptor agonist with an EC₅₀ of 2.4 nM and also a β₁- and β₂-adrenergic receptor** antagonist.

Nesvategrast SF0166	Integrin	Metabolic Disease
Nesvategrast (SF0166) is a potent and selective α_vβ₃ antagonist with IC₅₀ values of 0.6 nM, 8 nM, and 13 nM for α_vβ₃, α_vβ₆, and α_vβ₈, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC₅₀ values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model .

ZD-7114 hydrochloride ICI-D 7114 hydrochloride	Adrenergic Receptor	Endocrinology
ZD-7114 hydrochloride is a potent and selective agonist of *β3-adrenergic*. ZD-7114 hydrochloride is a selective thermogenic agent in vivo. ZD-7114 hydrochloride can be used in study obesity and diabetes .

N-5984 KRP-204	Adrenergic Receptor	Inflammation/Immunology Cancer
N-5984 (KRP-204) is a potent and selective agonist of β3-adrenergic receptor. N-5984 has the potential for developing as one of the clinically effective drugs for obesity and diabetes mellitus .

Carazolol (±)-Carazolol; DL-Carazolol; Suacron	Adrenergic Receptor	Cardiovascular Disease
Carazolol is a β₁/β₂ adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective *β₃-adrenoceptor* agonist .

Zalunfiban dihydrochloride RUC-4 dihydrochloride	Integrin	Cardiovascular Disease
Zalunfiban (RUC-4) dihydrochloride is a potent, selective platelet αIIbβ3 antagonist (IC₅₀=45 nM). Zalunfiban dihydrochloride can be used for the research of myocardial infarction (MI) .

Zalunfiban RUC-4	Integrin	Cardiovascular Disease
Zalunfiban (RUC-4) is a potent, selective platelet αIIbβ3 antagonist (IC₅₀=45 nM). Zalunfiban can be used for the research of myocardial infarction (MI) .

Etaracizumab LM 609; MEDI 523; Anti-αvβ3 Integrin Recombinant Antibody	Integrin	Cancer
Etaracizumab (LM 609) is an α_vβ₃ integrin IgG1 monoclonal antibody. Etaracizumab inhibits angiogenesis and melanoma tumor growth. Etaracizumab can be used to research anticancer .

D-Mannitol 4 Publications Verification Mannitol; Mannite	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA	Metabolic Disease Cancer
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells ^[3] .

L755507 1 Publications Verification	Adrenergic Receptor CRISPR/Cas9	Endocrinology Cancer
L755507 is a potent, selective agonist of *β₃-AR* with an IC₅₀ of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing in CRISPR/Cas9 nickase system ^[3].

SB-273005	Integrin	Inflammation/Immunology
SB-273005 is a potent nonpeptide and orally active integrin antagonist with K_is of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively .

Vibegron MK-4618	Adrenergic Receptor	Others
Vibegron (MK-4618) is a potent, highly selective and orally active *β₃-adrenoceptor* agonist (EC₅₀=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder ^[3].

Elarofiban RWJ-53308	Integrin	Cardiovascular Disease
Elarofiban (RWJ-53308) is a nonpeptide, orally active antagonist for fibrinogen receptor α_IIbβ₃ (GPIIb/IIIa), with an IC₅₀ of 0.15 nM. Elarofiban has the potential for platelet mediated thrombotic disorders research .

Cat. No.	Product Name	Type

HY-E70179

β-1,4-Glucuronyltransferase 1 EC 2.4.1.149; B4GAT1; β3GNTI	Enzyme Substrates
beta-1,4-Glucuronyltransferase 1 is a glucosyltransferase. beta-1,4-Glucuronyltransferase 1 transfers glucuronic acid towards both α and β anomers of xylose .

Cat. No.	Product Name	Target	Research Area

HY-P0023

Cyclo(-RGDfK) Maximum Cited Publications 10 Publications Verification	Integrin	Cancer
Cyclo(-RGDfK) is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

HY-P0023A

Cyclo(-RGDfK) TFA Maximum Cited Publications 10 Publications Verification	Integrin	Cancer
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface ^[3].

HY-100563

Cyclo(RGDyK) trifluoroacetate

3 Publications Verification

Integrin Cancer

Cyclo(RGDyK) trifluoroacetate is a potent and selective α_Vβ₃ integrin inhibitor with an IC₅₀ of 20 nM.
HY-100563A

Cyclo(RGDyK)

3 Publications Verification

Integrin Cancer

Cyclo(RGDyK) is a potent and selective α_Vβ₃ integrin inhibitor with an IC₅₀ of 20 nM.
HY-W205320

β,3-Dihydroxytyrosine

Peptides Others

β,3-Dihydroxytyrosine is an amino acid derivative .

HY-P1189

Echistatin	Integrin	Metabolic Disease Inflammation/Immunology
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ ^[3] .

HY-P1189A

Echistatin TFA	Integrin	Metabolic Disease Inflammation/Immunology
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ ^[3] .

HY-P0178

LXW7	Integrin	Inflammation/Immunology
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect ^[3].

HY-P1187

HSDVHK-NH2

Integrin Cancer

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-P0178A

LXW7 TFA	Integrin	Inflammation/Immunology
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect ^[3].

HY-P1187A

HSDVHK-NH2 TFA

Integrin Cancer

HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-P5098

E(c(RGDfK))2	Peptides	Cancer
E(c(RGDfK)) is an αvβ3 integrin-specific binding moiety with tumor targeting properties. Increased uptake of E(c(RGDfK)) in human ovarian cancer OVCAR-3 xenograft tumors may be useful in cancer research .

HY-P5133

Synstatin (92-119) SSTN92-119	Integrin	Cancer
Synstatin (92-119) is an anti-tumor agent that inhibits angiogenesis and cancer cell invasion. Synstatin (92-119) down-regulates integrin α?β3 and reduces the activation of angiogenic growth factors VEGF and FGF-2 .

HY-P0295

Gly-Arg-Gly-Asp-Ser GRGDS	Integrin	Others
Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM

HY-P0295A

Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA	Integrin	Inflammation/Immunology
Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM .

HY-P4320

Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10)	Integrin	Cancer
Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10), a decapeptide containing a cyclic RGD active sequence, is an Integrin αIIbβ3 antagonist that inhibits platelet and Adhesion of proMMP-13 .

HY-P1613

Cyclo(Arg-Gly-Asp-D-Phe-Val) Cyclo(RGDfV); C(RGDfV)	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .

HY-P1613A

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA Cyclo(RGDfV) TFA; C(RGDfV) TFA	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .

HY-P1365

α-Conotoxin MII α-CTxMII	nAChR	Neurological Disease
α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of *α3β2* subunits, with an IC₅₀ of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors ^[3].

HY-P1365A

α-Conotoxin MII TFA α-CTxMII TFA	nAChR	Neurological Disease
α-Conotoxin MII TFA (α-CTxMII TFA), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of *α3β2* subunits, with an IC₅₀ of 0.5 nM. α-Conotoxin MII TFA (α-CTxMII TFA) potently blocks β3-containing neuronal nicotinic receptors ^[3].

HY-P10038

mP6 Myr-FEEERA-OH	Integrin	Infection
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. mP6 inhibits the interaction of Gα₁₃ with integrin β₃ without disrupting talin-dependent integrin function. mP6 can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .

HY-P3726

Lys-Gln-Ala-Gly-Asp-Val	Integrin	Inflammation/Immunology Cancer
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α_2bβ₃ integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .

HY-P2300

Cyclo(Arg-Gly-Asp-D-Phe-Cys) Cyclo(RGDfC)	Integrin	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .

HY-P2300A

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA Cyclo(RGDfC) TFA	Integrin	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors .

HY-P4885

*Glp-amyloid-β (3-40) peptide (human)* AβpE3-40	Amyloid-β	Neurological Disease
Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .

HY-P5850

α-Conotoxin Bt1.8	nAChR	Neurological Disease
α-Conotoxin Bt1.8 is a potent *α6/α3β2β3* and *α3β2* nAChRs inhibitor with IC₅₀s of 2.1 nM and 9.4 nM against rat α6/α3β2β3 and α3β2, respectively .

HY-P4886

Amyloid β-Protein (3-42)	Peptides	Neurological Disease
Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) .

HY-P0031

Cyclo(RADfK) 1 Publications Verification	Integrin	Others
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

HY-P3713

Presenilin 1 (349-361)	Peptides	Cancer
Presenilin 1 (349-361) is an active petide, and synthetic peptides representing amino acids 349–361 can be phosphorylated by glycogen synthase kinase-3β(GSK3β) in vitro. Presenilin 1 (349-361) can be used for the research of various diseases .

Cat. No.	Product Name	Target	Research Area

HY-P99291

Etaracizumab LM 609; MEDI 523; Anti-αvβ3 Integrin Recombinant Antibody	Integrin	Cancer
Etaracizumab (LM 609) is an α_vβ₃ integrin IgG1 monoclonal antibody. Etaracizumab inhibits angiogenesis and melanoma tumor growth. Etaracizumab can be used to research anticancer .

HY-P99020

Fresolimumab 1 Publications Verification GC1008	TGF-β Receptor	Inflammation/Immunology Cancer
Fresolimumab (GC1008) is a high-affinity fully human monoclonal antibody that neutralizes the active form of human TGFβ1, TGFβ2, and TGFβ3. Fresolimumab can be used for the research of cancer and fibrotic diseases .

HY-P99560

Tadocizumab C4G1; YM-337	Integrin	Cardiovascular Disease
Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research .

Species:	Human (19) Mouse (5) Rat (1) Cynomolgus (1)
Tag:	His (19) Tag Free (1) Avi (4) Fc (3)
Source:	HEK293 (21) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P701015

	*Integrin alpha V beta 3* Protein, Mouse (Biotinylated, HEK293, His-Avi)** αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; Integrin alpha V β 3; β3	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 3 Protein, Mouse (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha V beta 3 Protein, Mouse (Biotinylated, HEK293, His-Avi), has molecular weight of 90-130 kDa.

HY-P700765

	*Integrin alpha V beta 3* Protein, Human (Biotinylated, HEK293, His-Avi)** αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; Integrin alpha V β 3; β3	Human	HEK293
	Integrin α V beta 5 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 3 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. Integrin alpha V beta 3 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 90-160 kDa.

HY-P700760

	*Integrin alpha V beta 3* Protein, Mouse (HEK293, hFc)** αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; Integrin alpha V β 3; β3	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 3 Protein, Mouse (HEK293, hFc) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-hFc labeled tag. Integrin alpha V beta 3 Protein, Mouse (HEK293, hFc), has molecular weight of 110-135 kDa & 50-60 kDa, respectively.

HY-P701063

	*Integrin alpha V beta 3* Protein, Cynomolgus (HEK293, His)** αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; Integrin alpha V β 3; β3	Cynomolgus	HEK293
	Integrin alpha V beta 3 Protein, part of the integrin alpha chain family, is highlighted. Integrin alpha V beta 3 Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 3 Protein, Cynomolgus (HEK293, His), has molecular weight of 95-140 kDa.

HY-P700761

	*Integrin alpha V beta 3* Protein, Mouse (HEK293, His)** αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; Integrin alpha V β 3; β3	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 3 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 3 Protein, Mouse (HEK293, His), has molecular weight of 90-130 kDa.

HY-P77719

	*Integrin alpha V beta 3* Protein, Human (HEK293, His-Avi)** Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-His, C-Avi labeled tag. Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi), has molecular weight of 85-140 kDa.

HY-P73868

	*Integrin alpha V beta 3* Protein, Human (HEK293, His, solution)** CD51; Integrin alpha V beta 3; integrin alpha-V; MSK8	Human	HEK293
	Integrin α V beta 3 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 3 Protein, Human (HEK293, His, solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha V beta 3 Protein, Human (HEK293, His, solution), has molecular weight of ~193.32 kDa.

HY-P700786

	*TGF beta 3/TGFB3 Protein, Human (HEK293, Avi)* TGF-beta-3; LAP; TGFB3; ARVD; ARVD1; RNHF; TGF-β-3	Human	HEK293
	Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. TGF beta 3/TGFB3 Protein, Human (HEK293, Avi) is the recombinant human-derived TGF beta 3/TGFB3 protein, expressed by HEK293 , with C-Avi labeled tag. The total length of TGF beta 3/TGFB3 Protein, Human (HEK293, Avi) is 112 a.a., with molecular weight of 15-20 kDa.

HY-P73868A

	*Integrin alpha V beta 3* Protein, Human (HEK293, C-His)**	Human	HEK293
	Integrin α V beta 3 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 3 Protein, Human (HEK293, C-His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293 , with C-10*His labeled tag. Integrin alpha V beta 3 Protein, Human (HEK293, C-His), has molecular weight of ~90.31 & 110-150 kDa, respectively.

HY-P7120

	*TGF beta 3/TGFB3 Protein, Human/Mouse/Rat (HEK293)* rHuTGF-β3; TGFB3; LAP	Human;Rat;Mouse	HEK293
	TGF-β3 (transforming growth factor-β3) is a member of a TGF-beta superfamily subgroup that performs many cellular functions. TGF-β3 has a role in embryogenesis and cell differentiation. TGF-β3 also plays a critical role in palatogenesis, the wound healing process. TGF-β3 is capable of binding directly to the type II receptor (TβRII). TGF beta 3/TGFB3 Protein, Human/Mouse/Rat (HEK293) is produced in HEK293 cells, and consists of 112 amino acids (A301-S412).

HY-P7893

	*CG beta 3* Protein, Human (HEK293, His)** rHuChoriogonadotropin subunit beta 3/CGB3, His; Choriogonadotropin subunit beta; CG-beta; Chorionic gonadotrophin chain beta; CGB3; CGB	Human	HEK293
	CG beta 3 Protein, Human(HEK 293, His) is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG).

HY-P700890

	*Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His)* TGFB3; ARVD; TGF-beta3; TGF-β; TGFβ3; TGFβ	Human	HEK293
	Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His) is 389 a.a., with molecular weight of 46-50 kDa & 55-60 kDa, respectively.

HY-P70056

	CHRNB3 Protein, Human (HEK293, His) rHuNeuronal acetylcholine receptor subunit beta-3/CHRNB3, His ; Neuronal acetylcholine receptor subunit beta-3	Human	HEK293
	CHRNB3 Protein, a vital constituent of the acetylcholine receptor (AChR), induces a significant conformational shift upon acetylcholine binding. This change affects all subunits, leading to the activation of an ion-conducting channel across the plasma membrane. The neuronal AChR complex comprises alpha and beta subunits, emphasizing their intricate collaboration in responding to acetylcholine stimulation. CHRNB3 Protein, Human (HEK293, His) is the recombinant human-derived CHRNB3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CHRNB3 Protein, Human (HEK293, His) is 208 a.a., with molecular weight of 30-40 kDa.

HY-P77716

	*Integrin alpha 2B beta 3* Protein, Human (HEK293, His)** ITGA2B&ITGB3; ITGA2B; ITGB3	Human	HEK293
	Integrin alpha 2B beta 3 Protein, found on platelets, plays a crucial role in blood clotting. It binds to fibrinogen, facilitating platelet aggregation and forming stable clots. Understanding the functions of Integrin alpha 2B beta 3 Protein can help in developing therapies for clotting disorders and improving hemostasis. Integrin alpha 2B beta 3 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2B beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2B beta 3 Protein, Human (HEK293, His), has molecular weight of 95-115 kDa.

HY-P701080

	*Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His)* TGFB3; ARVD; TGF-beta3; TGF-β; TGFβ3; TGFβ	Human	HEK293
	Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) is 389 a.a., with molecular weight of 43-48 kDa & 50-60 kDa, respectively.

HY-P700754

	*Integrin alpha 2B beta 3* Protein, Mouse (HEK293, His)** α2Bβ3; ITGA2B&ITGB3; ITGA2B; ITGB3	Mouse	HEK293
	Integrin alpha-IIb/beta-3, a versatile receptor recognizing various ligands, plays a pivotal role in platelet function and hemostasis. It binds fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin through the R-G-D sequence, particularly recognizing the H-H-L-G-G-G-A-K-Q-A-G-D-V sequence in fibrinogen. Activated, it facilitates platelet-platelet interactions by binding soluble fibrinogen, leading to rapid platelet aggregation. Structurally, it forms a heterodimer with the alpha subunit consisting of a heavy and a light chain linked by a disulfide bond, and the alpha-IIb subunit associates with beta-3. Its diverse interactions, including RNF181, CIB1-4, and PPIA/CYPA, underscore its integral role in orchestrating platelet responses. Integrin alpha 2B beta 3 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha 2B beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2B beta 3 Protein, Mouse (HEK293, His), has molecular weight of 90-113 kDa.

HY-P76738

	B3GALT5 Protein, Human (HEK293, Fc) Beta-1,3-galactosyltransferase 5; Beta3Gal-T5; Beta-3-Gx-T5	Human	HEK293
	B3GALT5 protein plays a pivotal role in catalyzing the transfer of galactose (Gal) to GlcNAc-based acceptors, exhibiting a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Additionally, it demonstrates efficient acceptor activity with glycolipid LC3Cer. B3GALT5 Protein, Human (HEK293, Fc) is the recombinant human-derived B3GALT5 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of B3GALT5 Protein, Human (HEK293, Fc) is 282 a.a., with molecular weight of ~62 kDa.

HY-P76739

	B3GALT5 Protein, Human (sf9, His) Beta-1,3-galactosyltransferase 5; Beta3Gal-T5; Beta-3-Gx-T5	Human	Sf9 insect cells
	B3GALT5 protein plays a pivotal role in catalyzing the transfer of galactose (Gal) to GlcNAc-based acceptors, exhibiting a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Additionally, it demonstrates efficient acceptor activity with glycolipid LC3Cer. B3GALT5 Protein, Human (sf9, His) is the recombinant human-derived B3GALT5 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of B3GALT5 Protein, Human (sf9, His) is 282 a.a., with molecular weight of ~35.2 KDa.

HY-P76634

	SCN3B Protein, Human (HEK293, Fc) Sodium channel subunit beta-3; SCN3B; KIAA1158	Human	HEK293
	The SCN3B protein critically affects sodium channel dynamics, inducing unique sustained currents and slower inactivation rates compared to beta-1. Its interaction with NFASC is shown to guide sodium channels to the nodes of Ranvier during axonal development and retain them in mature myelinated axons. SCN3B Protein, Human (HEK293, Fc) is the recombinant human-derived SCN3B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SCN3B Protein, Human (HEK293, Fc) is 159 a.a., with molecular weight of 50-55 kDa.

HY-P76635

	SCN3B Protein, Human (HEK293, His) Sodium channel subunit beta-3; SCN3B; KIAA1158	Human	HEK293
	The SCN3B protein critically affects sodium channel dynamics, inducing unique sustained currents and slower inactivation rates compared to beta-1. Its interaction with NFASC is shown to guide sodium channels to the nodes of Ranvier during axonal development and retain them in mature myelinated axons. SCN3B Protein, Human (HEK293, His) is the recombinant human-derived SCN3B protein, expressed by HEK293 , with C-His labeled tag. The total length of SCN3B Protein, Human (HEK293, His) is 137 a.a., with molecular weight of 23-34 kDa, respectively.

HY-P700152AF

	*Animal-Free TGF beta 3/TGFB3 Protein, Human (His)* ARVD; ARVD1; LDS5; RNHF; TGFB3; TGF-B3	Human	E. coli
	Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Animal-Free TGF beta 3/TGFB3 Protein, Human (His) is the recombinant human-derived animal-FreeTGF beta 3/TGFB3 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free TGF beta 3/TGFB3 Protein, Human (His) is 112 a.a., with molecular weight of ~13.66 kDa.

HY-P76740

	B3GALTL Protein, Human (HEK293, His) Beta-1,3-glucosyltransferase; Beta3Glc-T; B3GLCT; B3GTL	Human	HEK293
	B3GALTL Protein s a novel glycosyltransferase found in multicellular animals such as mammals, insects, and nematodes. B3GALTL plays important roles in variety of biological processes and encodes enzymes that catalyze the attachment of asugar molecule to specific acceptor sites. And it is involved in the synthesis of the disaccharide Glc-β1,3-Fuc-O-. Furthermore, mutations in the B3GALTL gene cause Peters Plus syndrome. B3GALTL Protein, Human (HEK293, His) is the recombinant human-derived B3GALTL protein, expressed by HEK293 , with N-His labeled tag. The total length of B3GALTL Protein, Human (HEK293, His) is 466 a.a., with molecular weight of ~56 kDa.

HY-P76741

	B3GNT6 Protein, Human (sf9, His) Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; Core 3 synthase; Beta3Gn-T6	Human	Sf9 insect cells
	B3GNT6 Protein, a vital beta-1,3-N-acetylglucosaminyltransferase, is crucial for synthesizing the core 3 structure of O-glycans, essential in mucin-type glycoprotein biosynthesis. With a key role in digestive organs, B3GNT6 significantly contributes to glycoconjugate structural diversity and functional properties. Its involvement in core 3 O-glycan synthesis is vital for mucin formation, impacting cell adhesion and mucosal protection processes. Understanding B3GNT6's role enhances glycosylation pathway comprehension, with potential applications in digestive organ physiology and glycan-related therapeutic targets. Further investigation promises insights into mucin-type glycoprotein biosynthesis in health and disease. B3GNT6 Protein, Human (sf9, His) is the recombinant human-derived B3GNT6 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of B3GNT6 Protein, Human (sf9, His) is 341 a.a., with molecular weight of ~47 kDa.

HY-P7870

	CGA-CGB3 Heterodimer Protein, Human (HEK293, His) rHuGlycoprotein hormones alpha chain, C-Flag&Choriogonadotropin subunit beta 3, His; Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alph	Human	HEK293
	The CG alpha protein, a shared alpha chain in glycoprotein hormones (TSH, LH, FSH, CG), binds to receptors, initiating signaling pathways. Heterodimeric hormones involve CG alpha and a specific beta chain (TSHB, LHB, FSHB, CGB), imparting biological specificity. CGA-CGB3 Heterodimer Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived CGA-CGB3 Heterodimer protein, expressed by HEK293 , with C-6*His labeled tag. CGA-CGB3 Heterodimer Protein, Human (HEK293, His), has molecular weight of 22 & 30-35 kDa, respectively.

Cat. No.	Product Name	Chemical Structure

HY-135119

Salmeterol-d3
Salmeterol-d₃ is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].

HY-14773S

(Rac)-Mirabegron-d5

(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist[1].

HY-14300AS

Vilanterol-d4 trifenatate
Vilanterol-d₄ (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.

HY-17453S

Salmeterol-d3 xinafoate
Salmeterol-d₃ (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].

HY-17453S1

Salmeterol-13C6 xinafoate
Salmeterol- ¹³C₆ (xinafoate) is the ¹³C₆ labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium

Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].

HY-135582S1

Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4'-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. [1][2]. Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[3].

HY-135582S

Raloxifene 4'-glucuronide-d4

Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression ^[3].

HY-146767S

(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d4

(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d₄ is deuterium labeled (3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid.

HY-16579AS2

Etifoxine-d5
Etifoxine-d₅ is the deuterium labeled Etifoxine. Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P80419

*Integrin beta 3* Antibody**	WB, IHC-P, ICC/IF	Human, Mouse
Integrin beta 3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to Integrin beta 3. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P82949

*Phospholipase C beta 3* Antibody (YA2694)** PLCB3; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3	WB, IHC-P	Human

HY-P82456

ATP1B3 Antibody (YA2201)

atp1b3; ATPB3; CD298; FLJ29027; NKAB3S; Sodium pump subunit beta 3; Sodium/potassium dependent ATPase subunit beta 3
WB Mouse, Rat
HY-P82402

Guanylyl Cyclase beta 1 Antibody (YA2147)

GCbeta1; GCS beta 1; GCS beta 3; GUC1B3; GUCSB3; GUCY1B1; Gucy1b1; GUCY1B3; SGC
WB, IHC-P Human, Mouse, Rat

HY-P80570

beta III Tubulin Antibody TUBB3; TUBB4; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
beta III Tubulin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 50 kDa, targeting to beta III Tubulin. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81229

PI3 Kinase p110 beta Antibody PI3-kinase p110 subunit beta; p110 BETA; p110Beta; PI3K beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat(predicted: Dog, Cow, Horse, Rabbit)
PI3 Kinase p110 beta Antibody is an unconjugated, approximately 123 kDa, rabbit-derived, anti-PI3 Kinase p110 beta polyclonal antibody. PI3 Kinase p110 beta Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: dog, cow, horse, rabbit background without labeling.

HY-P81211

phospho-PI3 Kinase p110 beta (Ser1070) Antibody PI3-kinase p110 subunit beta; p-PI3Kβ(Ser1070); PI 3-kinase C2β; p110 BETA; p110Beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow, Horse, Guinea Pig)
phospho-PI3 Kinase p110 beta (Ser1070) Antibody is an unconjugated, approximately 110-123 kDa, rabbit-derived, anti-phospho-PI3 Kinase p110 beta (Ser1070) polyclonal antibody. phospho-PI3 Kinase p110 beta (Ser1070) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, horse, guinea pig background without labeling.

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