Cap 1 synthons

By Targets:	ADC Linker (1) Androgen Receptor (1) Antibiotic (5) Antifolate (1) Apoptosis (1) Autophagy (2) Bacterial (9) Beta-lactamase (3) Biochemical Assay Reagents (5) CMV (2) DNA/RNA Synthesis (21) Endogenous Metabolite (12) Eukaryotic Initiation Factor (eIF) (2) Fluorescent Dye (1) HBV (1) HDAC (1) HSV (1) Influenza Virus (35) Isotope-Labeled Compounds (7) Liposome (3) MAPKAPK2 (MK2) (1) Mitochondrial Metabolism (1) MMP (1) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (8) Parasite (1) PROTACs (1) SARS-CoV (1) Small Interfering RNA (siRNA) (4) Somatostatin Receptor (1) TRP Channel (1) Virus Protease (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (2) Infection (52) Inflammation/Immunology (11) Metabolic Disease (7) Neurological Disease (2)
Click Chemistry:	Azide (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS01880

CAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAP1 Human Pre-designed siRNA Set A CAP1 Human Pre-designed siRNA Set A

HY-E70081

*mRNA Cap* 2'-O-methyltransferase**	Biochemical Assay Reagents	Others
mRNA Cap 2'-O-methyltransferase uses S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2'-O position of the first nucleotide at the 5’ end of Cap-0 mRNA, resulting in Cap-1 structure. Cap-1 structure promotes translation efficiency, increasing subsequent protein expression ^[1].

HY-160957

Cap A (Acetonitrile/Acetic Anhydride, 80/20 v/v)	DNA/RNA Synthesis	Others
Cap A (Acetonitrile/Acetic Anhydride, 80/20 v/v) is a capping reagent that can be used in DNA/RNA synthesis ^[1].

HY-164059

LZCap AG(3'Acm) mCherry mRNA	Others	Others
mCherry is a red fluorescent protein the derived from Discosoma sp.. mCherry has excitation/emission wavelengths of 587 nm/610 nm. LZCap AG(3'Acm) mCherry mRNA is synthesized and purified in a one-step transcription process using T7 RNA polymerase and LZCap AG(3'Acm) cap analog from a linear template. LZCap AG(3'Acm) generates a Cap1 structure mRNA post-transcription, providing more efficient and stable expression compared to Cap0 and other commercially available Cap1 structures. LZCap AG(3'Acm) mCherry mRNA contains poly A, optimized 5'UTR, and 3'UTR structures to improve mRNA stability and promote translation efficiency, resulting in enhanced expression. Upon entering cells, LZCap AG(3'Acm) mCherry mRNA expresses red fluorescence, suitable for experiments related to mRNA delivery, translation efficiency, transfection efficiency, and in vivo imaging.

HY-145982

m7GpppCmpG	Nucleoside Antimetabolite/Analog	Others
m7GpppCmpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppCmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-145981

m7GpppCpG	Nucleoside Antimetabolite/Analog	Others
m7GpppCpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-145979

m7GpppUmpG	Nucleoside Antimetabolite/Analog	Others
m7GpppUmpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppUmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-145980

m7GpppUpG	Nucleoside Antimetabolite/Analog	Others
m7GpppUpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppUpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures ^[1].

HY-160958

Cap B (Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v)	Biochemical Assay Reagents	Others
Cap B (Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v) is a biochemical reagent, which contains 50% Acetonitrile, 20 N-methylimidazole and 30% pyridine. Cap B (Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v) is utilized as capping agent in oligonucleotide synthesis ^[1].

HY-P3911

CAP 37 (20-44)	Bacterial	Infection
CAP 37 (20-44) is a peptide based on amino acid residues 20 through 44 of CAP37. CAP37, a Cationic antimicrobial protein of 37 kDa, is a multifunctional protein ^[1].

HY-D0869S

3-(Cyclohexylamino)-1-propanesulfonic Acid-d17	Isotope-Labeled Compounds	Others
3-(Cyclohexylamino)-1-propanesulfonic Acid-d₁₇ is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].

HY-143770

Cap-dependent endonuclease-IN-16	Influenza Virus	Infection
Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) ^[1].

HY-132894

Cap-dependent endonuclease-IN-1	Influenza Virus	Infection
Cap-dependent endonuclease-IN-1 is an orally active cap-dependent endonuclease inhibitor with high potency. Cap-dependent endonuclease-IN-1 can be used for the research of influenza ^[1] .

HY-143776

Cap-dependent endonuclease-IN-22

Influenza Virus Infection

Cap-dependent endonuclease-IN-22 is a potent cap-dependent endonuclease (CEN) inhibitor ^[1].

Cap-dependent endonuclease-IN-22	Influenza Virus	Infection
Cap-dependent endonuclease-IN-22 is a potent cap-dependent endonuclease (CEN) inhibitor ^[1].

HY-143781

Cap-dependent endonuclease-IN-26	Influenza Virus	Infection
Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC₅₀ of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains ^[1].

HY-P2458

CAP18 (rabbit)	Bacterial	Infection
CAP18 (rabbit) is a 37 amino acids antimicrobial peptide originally isolated from rabbit granulocytes. CAP18 (rabbit) has broad antimicrobial activity against both Gram-positive (IC₅₀, 130-200 nM) and Gram-negative (IC₅₀, 20-100 nM) bacteria. CAP18 (rabbit) has the potential for bacterial sepsis research ^[1].

HY-144065

Cap-dependent endonuclease-IN-19	Influenza Virus	Infection
Cap-dependent endonuclease-IN-19 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-19 is a spirocyclic pyridone derivative. Cap-dependent endonuclease-IN-19 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN111410661A, compound 1) ^[1].

HY-143749

Cap-dependent endonuclease-IN-6	Influenza Virus	Infection
Cap-dependent endonuclease-IN-6 (compound 13) is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-6 shows inhibition against influenza virus (EC₅₀=38.21 nM) ^[1].

HY-143768

Cap-dependent endonuclease-IN-14	Influenza Virus	Infection
Cap-dependent endonuclease-IN-14 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-14 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-14 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113620948A, compound 1-c) ^[1].

HY-143769

Cap-dependent endonuclease-IN-15	Influenza Virus	Infection
Cap-dependent endonuclease-IN-15 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-15 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-15 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113226327A, compound c-1) ^[1].

HY-144068

Cap-dependent endonuclease-IN-25	Influenza Virus	Infection
Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-25 is a macrocyclic pyridotriazine derivative. Cap-dependent endonuclease-IN-25 has the potential for the research of viral infections caused by viruses belonging to the Orthomyxoviridae family (extracted from patent WO2020075080A1, compound 4) ^[1].

HY-143762

Cap-dependent endonuclease-IN-12	Influenza Virus	Infection
Cap-dependent endonuclease-IN-12 (EXP-35) is a potent Cap-dependent endonuclease inhibitor with low cytotoxicity. Cap-dependent endonuclease-IN-12 shows inhibitory activity against H1N1 ^[1].

HY-143750

Cap-dependent endonuclease-IN-7	Influenza Virus	Infection
Cap-dependent endonuclease-IN-7 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-7 Inhibits the synthesis of viral mRNA and eventually inhibits virus proliferation. Cap-dependent endonuclease-IN-7 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2020177715A1, compound 5) ^[1]

HY-163621

Cap-dependent endonuclease-IN-28	Influenza Virus	Infection
Cap-dependent endonuclease-IN-28 (Compound 11) is a potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-28 inhibits CEN of TOSV, ANDV, and LACV viruses with IC₅₀ values of 2.4, 0.5, and 4 μM, respectively ^[1].

HY-162242

Cap-dependent endonuclease-IN-27	Influenza Virus	Infection
Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase (EC₅₀ = 12.26 nM) ^[1].

HY-143766

Cap-dependent endonuclease-IN-13	Influenza Virus	Infection
Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-13 has the potential for the research of influenza virus infection (only influenza A) (extracted from patent WO2021180147A1, compound I-1) ^[1].

HY-143752

Cap-dependent endonuclease-IN-8	Influenza Virus	Infection
Cap-dependent endonuclease-IN-8 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-8 inhibits replication of orthomyxoviruses (including influenza A, influenza B and influenza C) (extracted from patent CN111410661A, compound I-196) ^[1].

HY-145974

m7GpppAmpG

m7G(5')ppp(5')(2'OMeA)pG
DNA/RNA Synthesis Others

m7GpppAmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90% ^[1].

m7GpppAmpG m7G(5')ppp(5')(2'OMeA)pG	DNA/RNA Synthesis	Others
m7GpppAmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90% ^[1].

HY-145974A

m7GpppAmpG ammonium m7G(5')ppp(5')(2'OMeA)pG ammonium	DNA/RNA Synthesis	Others
m7GpppAmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90% ^[1].

HY-145977A

m7GpppGmpG ammonium

DNA/RNA Synthesis Others

m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86% ^[1].

m7GpppGmpG ammonium	DNA/RNA Synthesis	Others
m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86% ^[1].

HY-143744

Cap-dependent endonuclease-IN-3	Influenza Virus	Infection
Cap-dependent endonuclease-IN-3 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-3 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-3 has the potential for the research of influenza A and influenza B infection (extracted from patent WO2019141179A1, compound VI-1) ^[1].

HY-143743

Cap-dependent endonuclease-IN-2	Influenza Virus	Infection
Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-2 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-2 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent WO2019052565A1, compound 28) ^[1].

HY-143755

Cap-dependent endonuclease-IN-9	Influenza Virus	Infection
Cap-dependent endonuclease-IN-9 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-9 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-9 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN112521386A, compound VI-1) ^[1].

HY-143775

Cap-dependent endonuclease-IN-20	Influenza Virus	Infection
Cap-dependent endonuclease-IN-20 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-20 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC₅₀ of 4.82 μM (CN112940009A; DSC801) ^[1].

HY-143771

Cap-dependent endonuclease-IN-17	Influenza Virus	Infection
Cap-dependent endonuclease-IN-17 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-17 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC₅₀ of 1.29 μM (CN112898346A; DSC701) ^[1].

HY-143747

Cap-dependent endonuclease-IN-5	Influenza Virus	Infection
Cap-dependent endonuclease-IN-5 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-5 inhibits influenza virus well, and/or has lower cytotoxicity, better in vivo pharmacokinetic properties and in vivo pharmacodynamic properties (extracted from patent WO2020078401A1, compound 13-1) ^[1].

HY-143757

Cap-dependent endonuclease-IN-10	Influenza Virus	Infection
Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-10 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo pharmacokinetic and in vivo pharmacodynamic properties, and better hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2021129799A1, compound 1-1) ^[1].

HY-144066

Cap-dependent endonuclease-IN-21	Influenza Virus	Infection
Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-21 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-21 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8B or 8A) ^[1].

HY-144067

Cap-dependent endonuclease-IN-23	Influenza Virus	Infection
Cap-dependent endonuclease-IN-23 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-23 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-23 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8A or 8B) ^[1].

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Endogenous Metabolite	Others
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues ^[1].

HY-150144

Uracil-m7GpppAmpG ammonium

DNA/RNA Synthesis Others

Uracil-m7GpppAmpG ammonium is a cap analog that can be used for mRNA synthesis.

Uracil-m7GpppAmpG ammonium	DNA/RNA Synthesis	Others
Uracil-m7GpppAmpG ammonium is a cap analog that can be used for mRNA synthesis.

HY-RS01881

CAP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for CAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAP2 Human Pre-designed siRNA Set A CAP2 Human Pre-designed siRNA Set A

HY-145977

m7GpppGmpG

DNA/RNA Synthesis Others

m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86% ^[1].

m7GpppGmpG	DNA/RNA Synthesis	Others
m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86% ^[1].

HY-105172

TT-232 Cap-232; TLN-232	Somatostatin Receptor	Inflammation/Immunology Cancer
TT-232 (CAP-232), a somatostatin derivative, is a peptide *SSTR1/SSTR4* agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent ^[1] .

HY-147339

M7G(3'-OMe-5')pppA(2'-OMe)

DNA/RNA Synthesis Others

M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.
HY-145975

m7Gpppm6AmpG

DNA/RNA Synthesis Others

m7Gpppm6AmpG is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG can be used for RNA synthesis in vitro ^[1].

M7G(3'-OMe-5')pppA(2'-OMe)	DNA/RNA Synthesis	Others
M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.

m7Gpppm6AmpG	DNA/RNA Synthesis	Others
m7Gpppm6AmpG is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG can be used for RNA synthesis in vitro ^[1].

HY-157504

2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA	Others	Others
2’-O-Methyl-5’-O-phosphonoadenylyl-(3’→5’)-guanosine (TEA) is a trinucleotide cap analogue that regulates protein expression in living cells ^[1].

HY-148771

MTX-23 PROTAC AR-V7 degrader-2	PROTACs Androgen Receptor Apoptosis	Cancer
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis ^[1].

HY-W340832

*18:1 Biotinyl Cap* PE**	Liposome	Cancer
18:1 Biotinyl Cap PE is a liposome to simulate biological phospholipid membrane. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble payloads can be trapped in the internal aqueous space of liposomes, while lipophilic payloads can partition into and become part of the lipid bilayer. Especially for delivering antisense oligonucleotides, it can overcome problems such as inefficient cellular uptake and rapid loss in the body ^[1].

HY-145976

m7GpppGpG	Nucleoside Antimetabolite/Analog	Others
m7GpppGpG, an oligonucleotide, is an M ⁷GpppNpG trinucleotide cap analogue. m7GpppGpG prevents premature degradation by 5′-exonucleases and recruits proteins required for pre-mRNA splicing, mRNA transport and initiation of protein biosynthesis ^[1].

Cat. No.	Product Name

HY-L901

50K Diversity Library

50000 compounds

MCE 50K Diversity Library consists of 50,000 lead-like compounds with multiple characteristics such as calculated good solubility (-3.2<logP<5), oral bioavailability (RotB<=10), drug transportability (PSA<120). These compounds were selected by dissimilarity search with an average Tanimoto Coefficient of 0.52. There are 36,857 unique scaffolds and each scaffold 1 to 7 compounds. What’s more, compounds with the same scaffold have as many functional groups as possible, which make abundant chemical spaces. This exceptionally diverse library is highly recommended for random screening against new as well as popular targets based its novel, diverse scaffolds, abundant chemical spaces and the convenience for subsequent modification.

HY-L904

Drug Fragment Library

1,000 compounds

The MCE Drug Fragment Library consists of 1,000 drug fragments. These drug fragments are derived from 2,946 FDA-approved drug molecules, and fragments from one drug can appear in other drugs, so these fragments are somewhat correlated with good PK/PD properties. Fragment-based screening can reserve enough chemical space for subsequent structural optimization. This compound library is an essential tool for drug screening based on FBDD (Fragment-Based Drug Discovery).

HY-L903

3D Diverse Fragment Library

5196 compounds

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments.

MCE 3D Diverse Fragment Library consists of 5,196 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.

HY-L905

Natural Product-like Library

5,000 compounds

Historically, natural products (NPs) have played a key role in drug discovery, especially for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular diseases (for example, statins) and multiple sclerosis (for example, fingolimod). Approximately 40 % of the drugs approved by the FDA during the last decades were natural products, their derivatives, or synthetic mimetics related to natural products.

MCE Natural Product-like Compound Library consists of 5,000 natural product-like compounds coming from a drug-like library. Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with natural products, and natural-likeness scoring is more than -2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Product Name	Type

HY-D0948

Celestine Blue

Dyes

Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO₂ nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen ^[1] .

Cat. No.	Product Name	Type

HY-145974A

m7GpppAmpG ammonium m7G(5')ppp(5')(2'OMeA)pG ammonium	Gene Sequencing and Synthesis
m7GpppAmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90% ^[1].

HY-E70081

*mRNA Cap* 2'-O-methyltransferase**	Biochemical Assay Reagents
mRNA Cap 2'-O-methyltransferase uses S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2'-O position of the first nucleotide at the 5’ end of Cap-0 mRNA, resulting in Cap-1 structure. Cap-1 structure promotes translation efficiency, increasing subsequent protein expression ^[1].

HY-145977A

m7GpppGmpG ammonium

Gene Sequencing and Synthesis

m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86% ^[1].
HY-150144

Uracil-m7GpppAmpG ammonium

Gene Sequencing and Synthesis

Uracil-m7GpppAmpG ammonium is a cap analog that can be used for mRNA synthesis.

HY-153108

3'-O-Me-m7G(5')ppp(5')G ARCA Cap	Biochemical Assay Reagents
3'-O-Me-m7G(5')ppp(5')G (ARCA cap), anti-reverse cap analog, has a special RNA cap structure. Is a common feature of the mRNA of some RNA viruses and eukaryotes. RNA cap structures serve as signals for translation initiation ^[1].

HY-145973A

3'OMe-m7GpppAmpG ammonium m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium	Gene Sequencing and Synthesis
3'OMe-m7GpppAmpG ammonium is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization ^[1].

HY-E70080

Vaccinia virus capping enzyme	Biochemical Assay Reagents
Vaccinia virus capping enzyme is a transcription initiation factor. Vaccinia virus capping enzyme is a heterodimer of D1 (844 aa) and D12 (287 aa) polypeptides that executes all three steps in m7GpppRNA synthesis. Vaccinia virus capping enzyme has been used widely as a reagent for capping and cap-labeling RNAs in vitro ^[1] .

HY-W102681

Caps sodium salt

Biochemical Assay Reagents

Caps sodium salt, a polyanion, is a surfactant. Caps sodium salt can be used as biological buffer (0.05 M, pH 11) for dialysis ^[1].

HY-D0869

CAPS N-Cyclohexyl-3-aminopropanesulfonic acid	Biochemical Assay Reagents
CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis ^[1] .

HY-W441004

DSPE-Thiol	Drug Delivery
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers ^[1].

HY-145975A

m7Gpppm6AmpG ammonium

Gene Sequencing and Synthesis

m7Gpppm6AmpG ammonium is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG ammonium can be used for RNA synthesis in vitro ^[1].

HY-139100

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine m7GpppA	Gene Sequencing and Synthesis
N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog that can be used for in vitro RNA transcription ^[1].

HY-W441002

DSPE-succinic acid	Drug Delivery
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics ^[1].

HY-139098

7-Methyl-diguanosine triphosphate m7Gp3G	Gene Sequencing and Synthesis
7-Methyl-diguanosine triphosphate (m7Gp3G) is a cap analog that can incorporated into mRNA. 7-Methyl-diguanosine triphosphate is involved in translation and mRNA degradation in mammalian cells ^[1].

HY-139101

Guanosine 5'-triphosphate-5'-adenosine GpppA	Gene Sequencing and Synthesis
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog ^[1] .

HY-21586B

7-Methyl-guanosine-5'-triphosphate sodium m7GTP sodium	Gene Sequencing and Synthesis
7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate sodium phosphorothioate analog is a potent cap-dependent translation inhibitor ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P0277

Carcinoembryonic antigen peptide 1

Cap1; CEA peptide
Peptides Cancer

Carcinoembryonic antigen peptide 1 (CAP1) is a tumor marker in lung cancer.

HY-105172

TT-232 Cap-232; TLN-232	Somatostatin Receptor	Inflammation/Immunology Cancer
TT-232 (CAP-232), a somatostatin derivative, is a peptide *SSTR1/SSTR4* agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent ^[1] .

HY-P3911

CAP 37 (20-44)	Bacterial	Infection
CAP 37 (20-44) is a peptide based on amino acid residues 20 through 44 of CAP37. CAP37, a Cationic antimicrobial protein of 37 kDa, is a multifunctional protein ^[1].

HY-P2458

CAP18 (rabbit)	Bacterial	Infection
CAP18 (rabbit) is a 37 amino acids antimicrobial peptide originally isolated from rabbit granulocytes. CAP18 (rabbit) has broad antimicrobial activity against both Gram-positive (IC₅₀, 130-200 nM) and Gram-negative (IC₅₀, 20-100 nM) bacteria. CAP18 (rabbit) has the potential for bacterial sepsis research ^[1].

HY-P4272

Tetraproline	Peptides	Others
Tetraproline is a fragment sequence in tristetraprolin (TTP). Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements ^[1].

Cat. No.	Product Name

HY-E0156

8-Channel Handheld Screw Cap Decapper

The MedChemExpress^® 8-Channel Handheld Screw Cap Decapper is a necessary tool for handling thousands of screw cap tubes. It can cap and open various types of screw cap tubes, making it convenient and fast to operate. This improves experimental efficiency and meets different needs.

HY-E0194

Round Cap Drivers for 8-Channel Handheld Screw Cap Decapper

The MedChemExpress^® Round Cap Drivers for 8-Channel Handheld Screw Cap Decapper is compatible with 8-Channel Handheld Screw Cap Decapper (HY-E0156), which can be used for Capping/Recapping FluidX Screw Caps.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0277

Carcinoembryonic antigen peptide 1 Cap1; CEA peptide	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Others
Carcinoembryonic antigen peptide 1 (CAP1) is a tumor marker in lung cancer.

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues ^[1].

HY-W001189

1,3-Dithiane	Infection Natural Products Classification of Application Fields Animals Source classification Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite
1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon ^[1]. 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward S. typhimurium TA98 and TA100 .

HY-N6772

Cytochalasin E	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Autophagy
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation ^[1] .

HY-N0086

N6-Methyladenosine 5 Publications Verification 6-Methyladenosine; N-Methyladenosine	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Influenza Virus Endogenous Metabolite
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-139101

Guanosine 5'-triphosphate-5'-adenosine GpppA	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog ^[1] .

HY-N7647

Methyl brevifolincarboxylate Brevifolincarboxylic acid methyl ester	Infection Structural Classification Natural Products Classification of Application Fields Canarium album (Lour.) Rauesch. Source classification Plants Burseraceae Disease Research Fields	Influenza Virus
Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation ^[1] .

HY-N2362

DL-Alanine DL-2-Aminopropionic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver ^[1] .

Species:	Human (14) Virus (2) Mouse (3) Rat (1) Staphylococcus aureus (2)
Tag:	His (18) SUMO (2) Tag Free (2) GST (1) Trx (1)
Source:	HEK293 (7) E. coli Cell-free (2) Sf9 insect cells (4) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P77153

	Prostasin/PRSS8 Protein, Human (HEK293, His) Channel-activating protease 1; Cap1; Serine protease 8	Human	HEK293
	Prostasin/PRSS8, with trypsin-like cleavage specificity, crucially activates the epithelial sodium channel (ENaC) by cleaving its gamma subunits (SCNN1G). This protein forms a heterodimeric complex, consisting of light and heavy chains connected by a disulfide bond. Prostasin/PRSS8 Protein, Human (HEK293, His) is the recombinant human-derived Prostasin/PRSS8 protein, expressed by HEK293 , with C-His labeled tag. The total length of Prostasin/PRSS8 Protein, Human (HEK293, His) is 293 a.a., with molecular weight of ~40 kDa.

HY-P77155

	Prostasin/PRSS8 Protein, Rat (HEK293, His) Channel-activating protease 1; Cap1; Serine protease 8	Rat	HEK293
	Prostasin/PRSS8 Protein, featuring trypsin-like cleavage specificity, crucially activates the epithelial sodium channel (ENaC) by cleaving gamma subunits (SCNN1G) and modulating ion transport. Structurally, it forms a disulfide bond-linked heterodimer with light and heavy chains, highlighting its intricate role in cellular responses. Prostasin/PRSS8 Protein, Rat (HEK293, His) is the recombinant rat-derived Prostasin/PRSS8 protein, expressed by HEK293 , with C-His labeled tag. The total length of Prostasin/PRSS8 Protein, Rat (HEK293, His) is 293 a.a., with molecular weight of ~32.9 KDa.

HY-P71625

	PARK7/DJ-1 Protein, Human (GST) 1 Publications Verification Cap1; DJ-1; DJ1; DJ1 protein ; Epididymis secretory sperm binding protein Li 67p; SP22	Human	E. coli
	The multifunctional PARK7/DJ-1 protein plays a key role in cellular defense against oxidative stress and cell death. It acts as an oxidative stress sensor, redox-sensitive chaperone and protease, and participates in neuroprotective mechanisms by stabilizing NFE2L2 and PINK1 proteins. PARK7/DJ-1 Protein, Human (GST) is the recombinant human-derived PARK7/DJ-1 protein, expressed by E. coli , with N-GST labeled tag. The total length of PARK7/DJ-1 Protein, Human (GST) is 188 a.a., with molecular weight of ~46.8 kDa.

HY-P77154

	Prostasin/PRSS8 Protein, Mouse (sf9, His) Channel-activating protease 1; Cap1; Serine protease 8	Mouse	Sf9 insect cells
	Prostasin/PRSS8 Protein, featuring trypsin-like cleavage specificity, crucially activates the epithelial sodium channel (ENaC) by cleaving gamma subunits (SCNN1G) and modulating ion transport. Structurally, it forms a disulfide bond-linked heterodimer with light and heavy chains, highlighting its intricate role in cellular responses. Prostasin/PRSS8 Protein, Mouse (sf9, His) is the recombinant mouse-derived Prostasin/PRSS8 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Prostasin/PRSS8 Protein, Mouse (sf9, His) is 260 a.a., with molecular weight of ~35 kDa.

HY-P702230

	CAP5A Protein, Staphylococcus aureus (Cell-Free, His) Capsular polysaccharide type 5 biosynthesis protein Cap5A	Staphylococcus aureus	E. coli Cell-free
	CAP5A Protein is crucial for biosynthesizing type 5 capsular polysaccharide (Cap5/CP5) and may function as a chain-length regulator. CAP5A Protein, Staphylococcus aureus (Cell-Free, His) is the recombinant Staphylococcus aureus-derived CAP5A protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CAP5A Protein, Staphylococcus aureus (Cell-Free, His) is 222 a.a., with molecular weight of 26.4 kDa.

HY-P702231

	CAP8A Protein, Staphylococcus aureus (Cell-Free, His) Capsular polysaccharide type 8 biosynthesis protein Cap8A	Staphylococcus aureus	E. coli Cell-free
	CAP8A Protein is essential for the biosynthesis of type 8 capsular polysaccharide (Cap8/CP8) and potentially functions as the chain-length regulator. CAP8A Protein, Staphylococcus aureus (Cell-Free, His) is the recombinant Staphylococcus aureus-derived CAP8A protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CAP8A Protein, Staphylococcus aureus (Cell-Free, His) is 319 a.a., with molecular weight of 26.4 kDa.

HY-P75601

	CAPG Protein, Human Macrophage-Capping protein; Actin regulatory protein Cap-G; CapG; AFCP; MCP	Human	E. coli
	Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca²⁺-sensitive protein and plays a role in macrophage function and is involved in the process of metastasis by promoting the invasiveness of tumor cells. CAPG Protein, Human is the recombinant human-derived CAPG protein, expressed by E. coli , with tag free. The total length of CAPG Protein, Human is 348 a.a., with molecular weight of ~42 kDa.

HY-P74622

	Porcine circovirus 2 Capsid protein (sf9, His) Capsid protein; Cap; ORF2	Virus	Sf9 insect cells
	The porcine circovirus 2 capsid protein autonomously constructs the icosahedral capsid of the viral particle, which is essential for initial attachment to host cell surface proteoglycans. Small size contributes to environmental stability and disinfectant resistance. Porcine circovirus 2 Capsid protein (sf9, His) is the recombinant Virus-derived Porcine circovirus 2 Capsid protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Porcine circovirus 2 Capsid protein (sf9, His) is 192 a.a., with molecular weight of ~23.8 kDa.

HY-P7624

	Azurocidin Protein, Human (HEK293, His) rHuAzurocidin, His; Azurocidin; Cationic Antimicrobial Protein Cap37; Heparin-Binding Protein	Human	HEK293
	Azurocidin Protein, Human (HEK293, His), a recombinant human Azurocidin produced in HEK293 cells, has a His tag. Azurocidin is a protein that is mobilized rapidly from emigrating polymorphonuclear leukocytes (PMN). Azurocidin serves as an important mediator during the initiation of the immune response.

HY-P7644

	BPI Protein, Human (HEK293, His) rHuBactericidal Permeability-Increasing Protein, His; Bactericidal permeability-increasing protein; BPI; Cap57	Human	HEK293
	BPI Protein, Human (HEK293, His), a member of a genomically conserved lipid-interactive protein family, belongs to a diverse group of polypeptides with antimicrobial activity that are thought to participate in antimicrobial host defence.

HY-P70886

	NDRG1 Protein, Human (His) Protein NDRG1; Differentiation-Related Gene 1 Protein; DRG-1; N-myc Downstream-Regulated Gene 1 Protein; Nickel-Specific Induction Protein Cap43; Reducing Agents and Tunicamycin-Responsive Protein; RTP; Rit42; NDRG1; Cap43; DRG1; RTP	Human	E. coli
	NDRG1 is a stress-responsive protein and an important tumor suppressor involved in hormone response and cell growth. It aids in Schwann cell transport, which is essential for the development of myelin in peripheral nerves. NDRG1 Protein, Human (His) is the recombinant human-derived NDRG1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NDRG1 Protein, Human (His) is 394 a.a., with molecular weight of ~50.0 kDa.

HY-P74525A

TGFBI Protein, Human(HEK293, His)

Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; RGD-Cap; BIGH3
Human HEK293

HY-P74525

	TGFBI Protein, Human (HEK293, His, solution) Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; RGD-Cap; BIGH3	Human	HEK293
	TGFBI Protein, a multifaceted regulator, plays a crucial role in cell adhesion, influencing diverse cellular processes. Its binding affinity for various collagens, such as type I, II, and IV, underscores its significance in mediating cellular responses and adhesion-related events. The protein's involvement in extracellular matrix interactions highlights its potential impact on cellular adhesion to different collagen types. TGFBI Protein, Human (HEK293, His, solution) is the recombinant human-derived TGFBI protein, expressed by HEK293 , with C-10*His labeled tag. The total length of TGFBI Protein, Human (HEK293, His, solution) is 660 a.a., with molecular weight of ~65 kDa.

HY-P76641

	Serpin B8 Protein, Mouse (sf9, His) Cytoplasmic antiproteinase 2; Cap-2; Peptidase inhibitor 8; PI-8; SERPINB8	Mouse	Sf9 insect cells
	The Serpin B8 protein plays a critical role in promoting epithelial desmosome-mediated intercellular adhesion, underscoring its importance in maintaining cell adhesion within epithelial tissues. The protein's involvement suggests an important contribution to the structural integrity and stability of desmosomes, key cellular structures that mediate adhesion between adjacent cells. Serpin B8 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B8 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Serpin B8 Protein, Mouse (sf9, His) is 374 a.a., with molecular weight of ~43.6 kDa.

HY-P71306

	Serpin B9 Protein, Human (HEK293, His) Cytoplasmic antiproteinase 3; Peptidase inhibitor 9; Cap3; PI-9; Serpin B9	Human	HEK293
	The Serpin B9 Protein, a member of the serpin family, crucially regulates immune responses by specifically inhibiting granzyme B, a protease involved in immune cell-mediated apoptosis. Acting as a potent inhibitor, Serpin B9 modulates granzyme B's cytotoxic activity, fine-tuning immune responses and preventing unwarranted cell death, emphasizing its significance in maintaining immune balance. Serpin B9 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B9 Protein, Human (HEK293, His) is 376 a.a., with molecular weight of 35-40 kDa.

HY-P70970

	Serpin B6 Protein, Human (Trx-His) Serpin B6; Cytoplasmic Antiproteinase; Cap; Peptidase Inhibitor 6; PI-6; Placental Thrombin Inhibitor; SERPINB6; PI6; PTI	Human	E. coli
	Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (Trx-His) is the recombinant human-derived Serpin B6 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of Serpin B6 Protein, Human (Trx-His) is 376 a.a., with molecular weight of 58-60 kDa.

HY-P76640

	Serpin B6 Protein, Human (sf9, His) Serpin B6; Cytoplasmic Antiproteinase; Cap; Peptidase Inhibitor 6; PI-6; Placental Thrombin Inhibitor; SERPINB6; PI6; PTI	Human	Sf9 insect cells
	Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (sf9, His) is the recombinant human-derived Serpin B6 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Serpin B6 Protein, Human (sf9, His) is 375 a.a., with molecular weight of ~43 kDa.

HY-P71604

	Transmembrane protease serine 4 Protein, Mouse (His-SUMO) Tmprss4; Cap2; Transmembrane protease serine 4; EC 3.4.21.-; Channel-activating protease 2; mCap2	Mouse	E. coli
	The transmembrane protease serine 4 (TMPRSS4) protein is a plasma membrane-anchored serine protease that is critical for activating molecular pathways. Its proteolytic activity directly processes pro-uPA/PLAU into its active form. Transmembrane protease serine 4 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Transmembrane protease serine 4 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Transmembrane protease serine 4 Protein, Mouse (His-SUMO) is 384 a.a., with molecular weight of ~57.8 kDa.

HY-P70152

	EIF4E Protein, Human rHuEukaryotic translation initiation factor 4E/EIF4E; Eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA Cap-binding protein; EIF4E; EIF4EL1; EIF4F	Human	E. coli
	IF4E protein plays multiple roles in cells, regulating processes such as protein synthesis, mRNA export, RNA processing and splicing. As part of the eIF4F protein complex, IF4E recognizes the mRNA cap and promotes ribosome binding. It is also involved in translation repression and regulation of mRNA stability. In P bodies, IF4E is involved in storing translationally inactive mRNA. In addition, IF4E also plays a role in spermatogenesis, neurogenesis, and mRNA nuclear-cytoplasmic transport. The ability of IF4E to participate in mRNA export relies on binding to the m7G cap and the EIF4E-sensitive element (4ESE). LRPPRC promotes the formation of EIF4E-dependent mRNA export complexes. The action of IF4E changes the composition of nuclear pores and promotes the nuclear export of specific mRNAs. EIF4E Protein, Human is the recombinant human-derived EIF4E protein, expressed by E. coli , with tag free. The total length of EIF4E Protein, Human is 217 a.a., with molecular weight of approximately 28 kDa.

HY-P71608

	TGS1 Protein, Human (His-SUMO) Cap specific guanine N2 methyltransferase; Cap-specific guanine-N2 methyltransferase; CLL associated antigen KW 2; CLL-associated antigen KW-2; DKFZp762A163; FLJ22995; HCA137; Hepatocellular carcinoma associated antigen 137; Hepatocellular carcinoma-associated antigen 137; NCOA6IP; Nuclear receptor coactivator 6 interacting protein; Nuclear receptor coactivator 6-interacting protein; PIMT; PIPMT; PRIP interacting protein PIPMT; PRIP interacting protein with methyltransferase domain; PRIP interacting protein with methyltransferase motif; PRIP-interacting protein with methyltransferase motif; SEREX defined; TGS 1; Tgs1; TGS1_HUMAN; Trimethylguanosine synthase; Trimethylguanosine synthase homolog (S. cerevisiae); Trimethylguanosine synthase homolog	Human	E. coli
	TGS1 protein plays a pivotal role in cellular processes by catalyzing the sequential methylation steps involved in the conversion of the 7-monomethylguanosine (m(7)G) caps of small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. This enzyme exhibits specificity for guanine, with N7 methylation preceding N2 methylation in the modification process. The hypermethylation of the m7G cap of U snRNAs results in their localization to nuclear foci, co-localization with coilin, and the formation of canonical Cajal bodies (CBs). Beyond its involvement in RNA modification, TGS1 also contributes to transcriptional regulation, underscoring its significance in cellular function. TGS1 Protein, Human (His-SUMO) is the recombinant human-derived TGS1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of TGS1 Protein, Human (His-SUMO) is 141 a.a., with molecular weight of ~31.6 kDa.

HY-P701227

	CEBPA Protein, Human (His) Apoptotic cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; C/ebpalpha; Cap4; Caspase 8 precursor; CBF-A; CCAAT Enhancer Binding Protein alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha; CEBP; CEBP A; CEBP alpha; Cebpa; CEBPA_HUMAN; FADD homologous; ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH	Human	E. coli
	CEBPA protein, also known as CCAAT/enhancer-binding protein α, is a transcription factor that plays a crucial role in regulating the expression of genes related to cell differentiation, proliferation, and metabolism. The reference paragraph states that CEBPA protein interacts with TAF1A and UBTF. CEBPA Protein, Human (His) is the recombinant human-derived CEBPA protein, expressed by E. coli , with N-His labeled tag. The total length of CEBPA Protein, Human (His) is 358 a.a., with molecular weight of ~44 kDa.

Cat. No.	Product Name	Chemical Structure

HY-D0869S

3-(Cyclohexylamino)-1-propanesulfonic Acid-d17
3-(Cyclohexylamino)-1-propanesulfonic Acid-d₁₇ is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity[1][2].

HY-N0086S

N6-Methyladenosine-d3
N6-Methyladenosine-d₃ (6-Methyladenosine-d₃; N-Methyladenosine-d₃) is a deuterium labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N0086S2

N6-Methyladenosine-13C4
N6-Methyladenosine- ¹³C₄ (6-Methyladenosine- ¹³C₄; N-Methyladenosine- ¹³C₄) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N0086S3

N6-Methyladenosine-13C3
N6-Methyladenosine- ¹³C₃ (6-Methyladenosine- ¹³C₃) is ¹³C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities ^[1] .

HY-N2362S2

DL-Alanine-d3

DL-Alanine-d₃ is the deuterium labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].

HY-W751835

Baloxavir-d4

20+ Cited Publications

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity ^[1] .

HY-N2362S

DL-Alanine-13C-1

DL-Alanine- ¹³C-1 is the ¹³C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].

HY-N2362S1

DL-Alanine-13C-3

DL-Alanine- ¹³C-3 is the ¹³C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].

HY-N2362S5

DL-Alanine-15N

DL-Alanine- ¹⁵N is the ¹⁵N labeled DL-Alanine[1]. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[2][3][4][5][6][7].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82016

PRSS8 Antibody (YA1761)

Cap1; PROSTASIN
WB, IP Human
HY-P83214

HCE Antibody (YA2959)

HCE; HCE1; hCap; Cap1A
WB, ICC/IF, IP Human, Rat

HY-P80581

	CAP2 Antibody Cap 2; Adenylyl cyclase-associated protein 2	WB, IP	Human
	CAP2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 53 kDa, targeting to CAP2. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P83323

BPI Antibody (YA3068)

rBPI; BPIFD1; Cap 57; BPI; Bactericidal permeability-increasing protein
WB, ICC/IF, FC Human
HY-P82635

Cathelicidin Antibody (YA2380)

LL37; Cap18; CRAMP; HSD26; Cap-18; FALL39; FALL-39
WB, IHC-P, IP Human
HY-P81826

PDZK1 Antibody (YA1571)

Cap70; CLAMP; PDZD1; NHERF3; NHERF-3
WB, IP Human

HY-P80976

	BRD4 Antibody Brd4; Cap; HUNK1; MCap; Bromodomain containing 4; chromosome associated protein	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	BRD4 Antibody is an antibody about 152 kDa, targeting to BRD4.

HY-P82873

	Phospho-NDRG1 (Ser330) Antibody (YA2618) Protein NDRG1; Differentiation-related gene 1 protein; DRG-1; RTP; Rit42; NDRG1; Cap43; DRG1; RTP; targ1; TDD5; tdds	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse

HY-P80812

	Phospho-eIF4E (Ser209) Antibody EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA Cap-binding protein	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-eIF4E (Ser209) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 25 kDa, targeting to Phospho-eIF4E (Ser209). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80774

	p21 Antibody CDKN1A; Cap20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21	WB, ICC/IF	Human, Mouse, Rat
	p21 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 18 kDa, targeting to p21. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80773

	p21 Antibody (YA254) CDKN1A; Cap20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21	WB	Human, Mouse
	p21 Antibody (YA254) is a non-conjugated and Rabbit origined monoclonal antibody about 18 kDa, targeting to p21. It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P80624

	Cleaved-Caspase 8 Antibody CASP8; MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; Cap4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Cleaved-Caspase 8 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 55 kDa, targeting to Cleaved-Caspase 8. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P81161

	CEBP-alpha Antibody Apoptotic cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; Cap4; Caspase 8 precursor; CCAAT Enhancer Binding Protein alpha; CEBP; CEBP A; CEBP alpha; CEBPA; FADD homologous ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH; MCH5; MORT1 associated CED 3 homolog; CEBP α, CEBP-α.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat
	CEBP-alpha Antibody is an unconjugated, approximately 39 kDa, rabbit-derived, anti-CEBP-alpha polyclonal antibody. CEBP-alpha Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, rat, and predicted: mouse, dog, pig, cow, rabbit, sheep, goat background without labeling.

Cat. No.	Product Name		Classification

HY-151829

Fmoc-L-Asn(EDA-N3)-OH		Azide
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II ^[1].


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Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

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Recombinant Proteins

Isotope-Labeled Compounds

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Click Chemistry