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Results for "

ferroptosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ferroptosis (110) Antibiotic (3) Apoptosis (23) Autophagy (13) Bacterial (6) Bcl-2 Family (2) COX (3) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (2) Endogenous Metabolite (15) FLT3 (3) Fluorescent Dye (6) Fungal (3) Glutathione Peroxidase (18) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) HIV (2) Influenza Virus (3) Isotope-Labeled Compounds (6) JNK (2) Keap1-Nrf2 (1) Lipoxygenase (1) MDM-2/p53 (3) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) Mitophagy (1) Necroptosis (1) NF-κB (3) Oxidative Phosphorylation (1) p62 (1) Parasite (1) Prostaglandin Receptor (1) PROTACs (3) Pyroptosis (3) Raf (3) Reactive Oxygen Species (18) Sodium Channel (2) STAT (2) TrxR (1) VDAC (1) VEGFR (3)
By Research Areas:	Cancer (97) Cardiovascular Disease (2) Endocrinology (1) Infection (7) Inflammation/Immunology (12) Metabolic Disease (10) Neurological Disease (15)
Click Chemistry:	Alkynes (2)

125

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Ferroptosis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163074

Ferroptosis-IN-6	Ferroptosis	Cancer
Ferroptosis-IN-6 (compound 13) is a potent inhibitor of *Ferroptosis* with EC₅₀ of 25.5 nM. Ferroptosis-IN-6 significantly inhibits RSL3-induced cell death in cells and in vivo .

HY-149719

Ferroptosis-IN-4	Ferroptosis	Metabolic Disease
Ferroptosis-IN-4 (compound 6k) is a *ferroptosis* inhibitor with EC₅₀ value of 20 μM. Ferroptosis-IN-4 has no obvious cytotoxicity. Ferroptosis-IN-4 has a protective effect in glycerol-induced RM-AKI mice with alleviating kidney dysfunction .

HY-N11885

Ferroptosis-IN-1	Ferroptosis	Cancer
Ferroptosis-IN-1 is a A. campylantha diterpenes. Ferroptosis-IN-1 inhibits *ferroptosis* with an EC₅₀ value of 10 μM. Ferroptosis-IN-1 can be used for neuroinflammation diseases research .

HY-149723

Ferroptosis-IN-5

Ferroptosis Cancer

Ferroptosis-IN-5 (compound 9c) is a ferroptosis inhibitor with iron-chelating and reactive oxygen species (ROS) scavenging activities .

Ferroptosis-IN-5	Ferroptosis	Cancer
Ferroptosis-IN-5 (compound 9c) is a *ferroptosis* inhibitor with iron-chelating and reactive oxygen species (ROS) scavenging activities .

HY-161460

Ferroptosis-IN-7	Ferroptosis Reactive Oxygen Species	Cardiovascular Disease
Ferroptosis-IN-7(Compound 26) is a *ferroptosis* inhibitor which can restore cell viability, reduce iron accumulation and scavenge reactive oxygen species. Ferroptosis-IN-7 can be used for vascular diseases research .

HY-149670

Ferroptosis-IN-3	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-3 (Compound 25) is a *ferroptosis* inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC₅₀: 8.6?nM in HT-1080?cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC₅₀: 3.94?and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation .

HY-145595

Ferroptosis inducer-1

Ferroptosis Cancer

Ferroptosis inducer-1 (compound BX-3a) is a Ferroptosis inducer with antitumor potential .

Ferroptosis inducer-1	Ferroptosis	Cancer
Ferroptosis inducer-1 (compound BX-3a) is a *Ferroptosis* inducer with antitumor potential .

HY-155852

Lepadin H	Ferroptosis	Others
Lepadin H is a marine alkaloid and *ferroptosis* inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-P10132

PRDX3(103-112), human	Ferroptosis	Metabolic Disease
PRDX3(103-112), human is a marker for *ferroptosis*. PRDX3 is hyperoxidated by mitochondrial lipid peroxides. PRDX3 inhibits cystine uptake after hyperoxidization .

HY-157222

Antitumor agent-125	Others	Cancer
Antitumor agent-125 (compound 17A) is a novel platinum(IV) prodrug. Antitumor agent-125 can activate the mitochondrion-dependent apoptosis pathway. Antitumor agent-125 induces *ferroptosis* in HCT-116/OXA .

HY-157068

icFSP1	Ferroptosis	Cancer
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 does not competitively inhibit FSP1 enzyme activity, but instead triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition .

HY-B1465

1-Hexadecanol

Palmityl alcohol
Endogenous Metabolite Others

1-Hexadecanol is a fatty alcohol, a lipophilic substrate. 1-Hexadecanol can be used for the research of ferroptosis .
HY-P10133

PRDX3(103-112) SO3 modified, human

Ferroptosis Metabolic Disease

PRDX3(103-112) SO3 modified, human is a marker of ferroptosis, and can be used for liver diseases study .

1-Hexadecanol Palmityl alcohol	Endogenous Metabolite	Others
1-Hexadecanol is a fatty alcohol, a lipophilic substrate. 1-Hexadecanol can be used for the research of ferroptosis .

PRDX3(103-112) SO3 modified, human	Ferroptosis	Metabolic Disease
PRDX3(103-112) SO3 modified, human is a marker of *ferroptosis*, and can be used for liver diseases study .

HY-139369

QD394	Reactive Oxygen Species	Cancer
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis .

HY-100887

Piperazine Erastin 5+ Cited Publications	Ferroptosis	Cancer
Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. Piperazine erastin can be used in cancer research .

HY-162311

Anticancer agent 194	Ferroptosis Autophagy Reactive Oxygen Species	Cancer
Anticancer agent 194 (compound 10p) is a *ferroptosis* and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS .

HY-161075

Microtubule inhibitor 8	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of microtubule. Microtubule inhibitor 8 triggers cell death through *ferroptosis*. Microtubule inhibitor 8 has anti-tumor effect .

HY-139001

JKE-1716	Glutathione Peroxidase Ferroptosis	Others
JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing *ferroptosis* selectively through covalent GPX4 inhibition .

HY-N11849

Moracin N	Ferroptosis Glutathione Peroxidase	Neurological Disease
Moracin N is a *ferroptosis* inhibitor that can be isolated from mulberry leaf. Moracin N exerts neuroprotective activity through preventing from oxidative stress .

HY-N0070

Solasonine 2 Publications Verification	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine is a *ferroptosis* inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-114481

Imidazole ketone erastin 20+ Cited Publications IKE	Ferroptosis	Cancer
Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system x_c ^- and an activator of *ferroptosis*. Imidazole ketone erastin has anti-tumor activity .

HY-162065

N6F11	Ferroptosis	Cancer
N6F11 is a *ferroptosis* inducer, and can trigger the degradation of glutathione peroxidase 4 (GPX4) specifically in cancer cells. N6F11 can be used for ferroptosis study .

HY-141809

GPX4-IN-3 1 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective *ferroptosis* inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

HY-163286

BODIQPy-TPA	Fluorescent Dye Ferroptosis	Others
BODIQPy-TPA is a lipophilic probes, which induces *ferroptosis* in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-136057

iFSP1 5+ Cited Publications	Ferroptosis	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces *ferroptosis* in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

HY-D1412

LPd peroxida probe	Ferroptosis	Others
LPd peroxida probe, a marker of ferroptosis, is a useful fluorescent probe for investigating the roles of lipid peroxidation in a variety of cell pathophysiologies. LPd peroxida probe reduces lipid hydroperoxides to lipid alcohols and is used for imaging lipid hydroperoxides in living cells .

HY-157744

Coumarin–quinone conjugate	Others
Coumarin–quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases which consists of a coumarin fluorophore and a ubiquinone analog. Coumarin–quinone conjugate can be used to measure the kinetic parameters of AIFM2/FSP1 for researches such as ferroptosis .

HY-W015273A

trans-3-Indoleacrylic acid	Endogenous Metabolite Ferroptosis	Metabolic Disease Cancer
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced *ferroptosis* via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis

HY-157788

ZX703	PROTACs Reactive Oxygen Species Ferroptosis Glutathione Peroxidase	Cancer
ZX703 (compound 5I) is a PROTAC that significantly degrades GPX4 in a dose- and time-dependent manner through the ubiquitin-proteasome and autophagy-lysosome pathways (DC₅₀=0.315 µM). ZX703 induces *ferroptosis* by inducing Reactive Oxygen Species (ROS) accumulation in cells. ZX703 can be used for cancer research .

HY-156286

GPX4-IN-7	Ferroptosis	Cancer
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC₅₀ value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis .

HY-158023

DHODH-IN-26	Dihydroorotate Dehydrogenase Reactive Oxygen Species Ferroptosis	Cancer
DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces *ferroptosis* .

HY-145828

Microtubule inhibitor 2	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 2 is a potent and selective, orally active microtubule inhibitor. Microtubule inhibitor 2 triggers cell death through *ferroptosis* . Microtubule inhibitor 2 shows antitumor activity .

HY-161332

Antitumor agent-143	Ferroptosis Pyroptosis Apoptosis Reactive Oxygen Species	Cancer
Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early apoptosis. Antitumor agent-143 induces cell death via *ferroptosis, apoptosis by a ROS-mediated mitochondrial dysfunction pathway and GSDMD-mediated pyroptosis* .

HY-138153

JKE-1674 1 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by *ferroptosis* inhibitors .

HY-155663

GPX4-IN-5	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC₅₀ value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce *ferroptosis* for the research of triple-negative breast cancer (TNBC) .

HY-155664

GPX4-IN-6	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC₅₀ value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce *ferroptosis* for the research of triple-negative breast cancer (TNBC) .

HY-D1301

BODIPY 581/591 C11 15+ Cited Publications	Fluorescent Dye Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect *ferroptosis* by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

HY-163506

Ebselen derivative 1	Apoptosis	Others
Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss .

HY-112063

CIL56

1 Publications Verification

Ferroptosis Cancer

CIL56 is a potent and selective ferroptosis inducer. Ferroptosis is an iron-dependent form of regulated cell death (RCD).

CIL56 1 Publications Verification	Ferroptosis	Cancer
CIL56 is a potent and selective *ferroptosis* inducer. Ferroptosis is an iron-dependent form of regulated cell death (RCD).

HY-157762

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research .

HY-158108

anti-TNBC agent-6	Autophagy Ferroptosis Reactive Oxygen Species	Cancer
anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC agent-6 induces autophagy and *ferroptosis. anti-TNBC agent-6 enhances intracellular ROS* accumulatio. anti-TNBC agent-6 shows anti tumor activity and has the potential for the research of breast cancer .

HY-152093

YL-939

Ferroptosis Cancer

YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis .

YL-939	Ferroptosis	Cancer
YL-939 is a potent *ferroptosis* inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis .

HY-103087

FIN56 5+ Cited Publications	Ferroptosis	Others
FIN56 is a specific inducer of *ferroptosis. FIN56 induces ferroptosis* by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

HY-112909

UAMC-3203

3 Publications Verification

Ferroptosis Neurological Disease Metabolic Disease Cancer

UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC₅₀ of 12 nM.

UAMC-3203 3 Publications Verification	Ferroptosis	Neurological Disease Metabolic Disease Cancer
UAMC-3203 is a potent and selective *Ferroptosis* inhibitor with an IC₅₀ of 12 nM.

HY-112909A

UAMC-3203 hydrochloride 3 Publications Verification	Ferroptosis	Neurological Disease Metabolic Disease Cancer
UAMC-3203 hydrochloride is a potent and selective *Ferroptosis* inhibitor with an IC₅₀ of 12 nM .

HY-145858

Chalcones A-N-5	Ferroptosis	Cancer
Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC₅₀ > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD .

HY-139087

Erastin2

Ferroptosis Others

Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter .
HY-138201

IM-93

Ferroptosis Cardiovascular Disease

IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 µM for cell death inhibition .
HY-12726

Liproxstatin-1

95+ Cited Publications

Ferroptosis Cancer

Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM) .

HY-Y0172

Butylated hydroxytoluene	Ferroptosis Endogenous Metabolite	Cancer
Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a *Ferroptosis* inhibitor .

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library

938 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 938 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

HY-L162

Cell Death Library

2,467 compounds

Cell death plays a crucial role in the development of the body and the maintenance of internal balance to prevent the development of diseases. According to the regulation of the involved processes, cell death can be defined as programmed and non-programmed death. Programmed cell death (PCD) can be divided into lytic cell death and nonlytic cell death, mainly including apoptosis, necrotic apoptosis and Pyroptosis. Non-Programmed cell death (Non-PCD) generally refers to necrosis. In stark contrast to Accidental Cell Death (ACD), Regulatory Cell Death (RCD) relies on specialized molecular mechanisms. Cell death includes internal apoptosis, external apoptosis, necrotic apoptosis, ferroptosis, pyroptosis, lysosome-dependent cell death, etc.

MCE designs a unique collection of 2,467 cell death compounds, covering multiple targets, such as Apoptosis, Ferroptosis, Pyroptosis, Necroptosis, etc. It is a useful tool for screening cell death drugs.

HY-L133

Cuproptosis Compound Library

188 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 188 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type

HY-D1412

LPd peroxida probe	Dyes
LPd peroxida probe, a marker of ferroptosis, is a useful fluorescent probe for investigating the roles of lipid peroxidation in a variety of cell pathophysiologies. LPd peroxida probe reduces lipid hydroperoxides to lipid alcohols and is used for imaging lipid hydroperoxides in living cells .

HY-D1301

BODIPY 581/591 C11

15+ Cited Publications

Fluorescent Dyes/Probes

BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

HY-163286

BODIQPy-TPA	Dyes
BODIQPy-TPA is a lipophilic probes, which induces *ferroptosis* in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-149203

MQA-P

Fluorescent Dyes/Probes

MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO ^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

HY-D2312

Mito-Rh-S	Fluorescent Dyes/Probes
Mito-Rh-S is a ratiometric near-infrared (NIR) fluorescent probe that detects the fluctuation of mitochondrial HClO levels during ferroptosis in hepatocellular carcinoma (HCC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1465

1-Hexadecanol Palmityl alcohol	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Hexadecanol is a fatty alcohol, a lipophilic substrate. 1-Hexadecanol can be used for the research of ferroptosis .

HY-N11849

Moracin N	Structural Classification Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Ferroptosis Glutathione Peroxidase
Moracin N is a *ferroptosis* inhibitor that can be isolated from mulberry leaf. Moracin N exerts neuroprotective activity through preventing from oxidative stress .

HY-N0070

Solasonine 2 Publications Verification	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Solanum nigrum Linn. Plants Solanaceae Disease Research Fields Cancer	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine is a *ferroptosis* inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-N11885

Ferroptosis-IN-1	Structural Classification Ophryosporus axilliflorus Hieron. Terpenoids Labiatae Source classification Diterpenoids Plants	Ferroptosis
Ferroptosis-IN-1 is a A. campylantha diterpenes. Ferroptosis-IN-1 inhibits *ferroptosis* with an EC₅₀ value of 10 μM. Ferroptosis-IN-1 can be used for neuroinflammation diseases research .

HY-155852

Lepadin H	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis
Lepadin H is a marine alkaloid and *ferroptosis* inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-W015273A

trans-3-Indoleacrylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Ferroptosis
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced *ferroptosis* via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis

HY-Y0172

Butylated hydroxytoluene	Structural Classification Monophenols Classification of Application Fields Leguminosae Source classification Phenols Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Ferroptosis Endogenous Metabolite
Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a *Ferroptosis* inhibitor .

HY-Y0172R

Butylated hydroxytoluene (Standard)	Structural Classification Monophenols Leguminosae Source classification Phenols Plants Endogenous metabolite Glycyrrhiza uralensis Fisch.	Ferroptosis Endogenous Metabolite
Butylated hydroxytoluene (Standard) is the analytical standard of Butylated hydroxytoluene. This product is intended for research and analytical applications. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a *Ferroptosis* inhibitor .

HY-B1645

Ammonium iron(III) citrate 5+ Cited Publications Ammonium ferric citrate; FAC	Ketones, Aldehydes, Acids Source classification Rutaceae Plants Disease Research Fields Citrus reticulata Blanco Cancer	Ferroptosis
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause *ferroptosis* . Ammonium iron(III) citrate can enhance protein production .

HY-149036

PAA5	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Ferroptosis Endogenous Metabolite Reactive Oxygen Species
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .

HY-66005

Acetaminophen 35+ Cited Publications Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite Ferroptosis
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. ^{. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .}

HY-B0215

Acetylcysteine Maximum Cited Publications 321 Publications Verification N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced *ferroptosis* by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities .

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Lactuca perennis Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids other families Microorganisms Leguminosae Disease Research Fields Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase
Gingerenone A is a Nrf2-Gpx4 activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-N8198

Ardisiacrispin B	Triterpenes Structural Classification Ardisia crenata Sims Classification of Application Fields Terpenoids Source classification Plants Myrsinaceae Disease Research Fields Cancer	Apoptosis Ferroptosis
Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death .

Cat. No.	Product Name	Chemical Structure

HY-Y0172S2

Butylated hydroxytoluene-d3
Butylated hydroxytoluene-d₃ is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a Ferroptosis inhibitor[3].

HY-Y0172S

Butylated hydroxytoluene-d21
Butylated hydroxytoluene-d₂₁ is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a Ferroptosis inhibitor[3].

HY-Y0172S1

Butylated hydroxytoluene-d24
Butylated hydroxytoluene-d₂₄ is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a Ferroptosis inhibitor[3].

HY-12726S1

Liproxstatin-1-15N

Liproxstatin-1- ¹⁵N is the ¹⁵N labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM) .
HY-12726S

Liproxstatin-1-13C6

Liproxstatin-1- ¹³C₆ is the ¹³C labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM) .

HY-14655S

Sulfasalazine-d4
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].

HY-14655S1

Sulfasalazine-d3,15N
Sulfasalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 *ferroptosis* inducer .

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-10201S2

Sorafenib-13C,d3

1 Publications Verification

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

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