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Results for "

penetrable

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) AAK1 (2) Akt (1) Amylin Receptor (1) Amyloid-β (16) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (7) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (11) Aurora Kinase (1) Autophagy (5) Bacterial (10) Bcl-2 Family (1) Bcr-Abl (1) Beta-secretase (4) Biochemical Assay Reagents (6) Calcium Channel (10) Cannabinoid Receptor (3) Caspase (3) CCR (1) Chloride Channel (1) Cholinesterase (ChE) (14) COX (3) CRFR (2) Cytochrome P450 (1) Dengue virus (1) Deubiquitinase (1) DNA Stain (2) DNA-PK (1) DNA/RNA Synthesis (1) Dopamine Receptor (6) Dopamine Transporter (1) EAAT (1) EGFR (3) Endogenous Metabolite (1) Epoxide Hydrolase (2) Eukaryotic Initiation Factor (eIF) (1) FAAH (1) FAK (1) FGFR (3) Flavivirus (1) Fluorescent Dye (17) Fungal (2) GABA Receptor (4) GSK-3 (5) HBV (4) HDAC (8) HIF/HIF Prolyl-Hydroxylase (4) Histamine Receptor (3) Histone Demethylase (1) Histone Methyltransferase (1) HIV (6) iGluR (2) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (1) Isotope-Labeled Compounds (5) JAK (1) LPL Receptor (2) LRRK2 (3) mAChR (2) MAGL (1) MCHR1 (GPR24) (1) MDM-2/p53 (4) mGluR (7) Microtubule/Tubulin (2) MMP (1) MNK (1) Monoamine Oxidase (10) nAChR (2) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) NF-κB (2) NO Synthase (1) Opioid Receptor (6) Orexin Receptor (OX Receptor) (1) Organoid (1) Oxytocin Receptor (1) P2X Receptor (1) PAI-1 (1) Parasite (5) PARP (4) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (1) PIKfyve (1) Potassium Channel (4) Prolyl Endopeptidase (PREP) (1) Proteasome (1) Reactive Oxygen Species (3) RET (1) Reverse Transcriptase (4) Ribosomal S6 Kinase (RSK) (1) RIP kinase (1) ROS Kinase (3) SARS-CoV (3) Sodium Channel (1) Src (1) STING (1) Syk (1) TGF-beta/Smad (1) Thyroid Hormone Receptor (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) Transferrin Receptor (2) Trk Receptor (2) TRP Channel (1) UGT (1) VEGFR (1) γ-secretase (1)
By Research Areas:	Cancer (51) Cardiovascular Disease (3) Endocrinology (8) Infection (27) Inflammation/Immunology (26) Metabolic Disease (14) Neurological Disease (129)
Click Chemistry:	Alkynes (3)

218

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-143896

STING agonist-7	STING	Cancer
STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly .

HY-153434

RIP1 kinase inhibitor 4	RIP kinase	Cancer
RIP1 kinase inhibitor 4 (Example 3) is a BBB-penetrable RIP1 kinase inhibitor (EC₅₀: <100 nM). RIP1 kinase inhibitor 4 can be used for the research of cell programming necrosis-related diseases . RIP1 kinase inhibitor 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-158082D

TRITC-dextran, MW 150000 Tetramethyl rhodamine isothiocyanate glucan, MW 150000	Fluorescent Dye	Others
TRITC-dextran, MW 150000 (Tetramethyl rhodamine isothiocyanate glucan, MW 150000) is a fluorescent dye, with the molecular weight of 150 kD. TRITC-dextran, MW 150000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 150000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 150000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082E

TRITC-dextran, MW 500000 Tetramethyl rhodamine isothiocyanate glucan, MW 500000	Fluorescent Dye	Others
TRITC-dextran, MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) is a fluorescent dye, with the molecular weight of 500 kD. TRITC-dextran, MW 500000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 500000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 500000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082H

TRITC-dextran, MW 2000000 Tetramethyl rhodamine isothiocyanate glucan, MW 2000000	Fluorescent Dye	Others
TRITC-dextran, MW 2000000 (Tetramethyl rhodamine isothiocyanate glucan, MW 2000000) is a fluorescent dye, with the molecular weight of 2000 kD. TRITC-dextran, MW 2000000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 2000000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 2000000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082

TRITC-dextran, MW 4000 Tetramethyl rhodamine isothiocyanate glucan, MW 4000	Fluorescent Dye	Others
TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082A

TRITC-dextran, MW 20000 Tetramethyl rhodamine isothiocyanate glucan, MW 20000	Fluorescent Dye	Others
TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082B

TRITC-dextran, MW 40000 Tetramethyl rhodamine isothiocyanate glucan, MW 40000	Fluorescent Dye	Others
TRITC-dextran, MW 40000 (Tetramethyl rhodamine isothiocyanate glucan, MW 40000) is a fluorescent dye, with the molecular weight of 40 kD. TRITC-dextran MW 40000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 40000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 40000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-P10235

Cyclic AC253	Amylin Receptor	Neurological Disease
Cyclic AC253 is an antagonist for amylin receptor, with IC₅₀ of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB) .

HY-124171

Zinquin ethyl ester	Fluorescent Dye	Others
Zinquin ethyl ester is a fluorescent derivative of Zinquin and is a fluorescent probe of cytosolic zinc. Zinquin ethyl ester is able to penetrate cell membranes and is lipophilic and zinc-sensitive. Zinquin ethyl ester can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence .

HY-147639

Cav 2.2/3.2 blocker 1	Calcium Channel	Neurological Disease
Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC₅₀ values of 78 μM and 80 μM against Ca_v2.2 and Ca_v3.2, respectively. Cav 2.2/3.2 blocker 1 can penetrate the CNS .

HY-101188

INCB38579	Histamine Receptor	Infection
INCB38579 is an orally active, highly brain penetrable, and selective histamine H₄ receptor (HH₄R) antagonist (hH₄R IC₅₀=4.8 nM, mH₄R IC₅₀=42 nM, rH₄R IC₅₀=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities .

HY-158082C

TRITC-dextran, MW 70000 Tetramethyl rhodamine isothiocyanate glucan, MW 70000	Fluorescent Dye	Others
TRITC-dextran, MW 70000 (Tetramethyl rhodamine isothiocyanate glucan, MW 70000) is a fluorescent dye, with the molecular weight of 70 kD. TRITC-dextran, MW 70000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 70000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-134228

4-Hydroperoxyifosfamide

Biochemical Assay Reagents Cancer

4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB) .
HY-119624

MOMIPP

PIKfyve Cancer

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB) .
HY-156986

ITH15004

P2X Receptor Neurological Disease

ITH15004 is a CNS-penetrated P2X7 antagonist, used for the study of neurodegenerative diseases .

4-Hydroperoxyifosfamide	Biochemical Assay Reagents	Cancer
4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB) .

MOMIPP	PIKfyve	Cancer
MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB) .

ITH15004	P2X Receptor	Neurological Disease
ITH15004 is a CNS-penetrated P2X7 antagonist, used for the study of neurodegenerative diseases .

HY-128351

SHR1653	Oxytocin Receptor	Neurological Disease Endocrinology
SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC₅₀ of 15 nM for hOTR .

HY-110191

VU0469650

mGluR Neurological Disease Cancer

VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu₁ receptor, with an IC₅₀ of 99 nM .
HY-14130

CP 376395

CRFR Neurological Disease Endocrinology

CP 376395 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist .

VU0469650	mGluR	Neurological Disease Cancer
VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu₁ receptor, with an IC₅₀ of 99 nM .

CP 376395	CRFR	Neurological Disease Endocrinology
CP 376395 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist .

HY-103379

CP 376395 hydrochloride	CRFR	Neurological Disease Endocrinology
CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist .

HY-W011704A

Phosphoenolpyruvic acid tricyclohexylammonium salt	Endogenous Metabolite	Others
Phosphoenolpyruvic acid tricyclohexylammonium salt is a glycolysis metabolite with a high-energy phosphate group, penetrates the cell membrane and exhibits cytoprotective and anti-oxidative activity .

HY-P2297

TfR-T12

Transferrin Receptor Metabolic Disease

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
HY-P2297A

TfR-T12 TFA

Transferrin Receptor Metabolic Disease

TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
HY-114958

RH 421

Fluorescent Dye Others

RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .
HY-15050

KCL-440

PARP Neurological Disease Inflammation/Immunology

KCL-440 is a CNS-penetrated PARP inhibitor, with an IC₅₀ of 68 nM. KCL-440 has strong inhibition of PARP-1 .

TfR-T12	Transferrin Receptor	Metabolic Disease
TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

TfR-T12 TFA	Transferrin Receptor	Metabolic Disease
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

RH 421	Fluorescent Dye	Others
RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

KCL-440	PARP	Neurological Disease Inflammation/Immunology
KCL-440 is a CNS-penetrated PARP inhibitor, with an IC₅₀ of 68 nM. KCL-440 has strong inhibition of PARP-1 .

HY-103253

LY231617	Others	Neurological Disease
LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease .

HY-106000

GSK239512	Histamine Receptor	Neurological Disease
GSK239512 is a potent and brain penetrated H₃ receptor antagonist. GSK239512 can be used for the research of mild-to-moderate Alzheimer's disease (AD) .

HY-157333

CYP51-IN-15

Parasite Cytochrome P450 Infection Inflammation/Immunology

CYP51-IN-15 (9B) is a BBB penetrated Naegleria fowleri-specific CYP51 inhibitor, with an EC₅₀ of 1.5 μM .

CYP51-IN-15	Parasite Cytochrome P450	Infection Inflammation/Immunology
CYP51-IN-15 (9B) is a BBB penetrated Naegleria fowleri-specific CYP51 inhibitor, with an EC₅₀ of 1.5 μM .

HY-134665

NITD-2	Flavivirus Dengue virus DNA/RNA Synthesis	Infection
NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly .

HY-153175

BT44	RET	Neurological Disease
BT44 is a selective RET activator. BT44 can penetrate through the blood-brain barrier and can be used for the research of neurodegenerative disorders and diabetes mellitus .

HY-131204

CZL80	Caspase	Neurological Disease
CZL80, a brain-penetrable caspase-1 inhibitor with an IC₅₀ of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility .

HY-121599

CGP 36742 SGS-742	GABA Receptor	Neurological Disease
CGP 36742 is a selective GABA_B receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC₅₀ of 32 μM. CGP 36742 is useful in treatment of depression .

HY-106147

Frakefamide	Opioid Receptor	Neurological Disease
Frakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system .

HY-147045

UCB-5307	TNF Receptor	Inflammation/Immunology
UCB-5307 is a potent TNF signaling inhibitor with a K_D of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex .

HY-113643

Levemopamil hydrochloride	Calcium Channel 5-HT Receptor	Neurological Disease
Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research .

HY-149253

OY-201	Others	Neurological Disease
OY-201 is a potential and BBB-penetrated anti-ischemic stroke agent. OY-201 shows the good safety and neuroprotective activity in both in vitro and in vivo models .

HY-106147B

Frakefamide TFA	Opioid Receptor	Neurological Disease
Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system .

HY-147372

SJ000063181	TGF-beta/Smad	Metabolic Disease
SJ000063181 is a potent BMP signaling activator with an EC₅₀ ≤1 µM. SJ000063181 can be used as chemical probes to interrogate BMP signaling due to it can penetrate zebrafish embryos .

HY-155024

HAT-IN-8

Parasite Infection

HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .

HAT-IN-8	Parasite	Infection
HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .

HY-119953

BIBN-99	mAChR	Neurological Disease
BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury .

HY-161090

AMPA receptor modulator-7	iGluR	Neurological Disease
AMPA receptor modulator-7 (compound 36) is a modulator of AMPA receptor. AMPA receptor modulator-7 has oral activity and can penetrate the blood-brain barrier .

HY-13909

RGFP966 25+ Cited Publications	HDAC	Cancer
RGFP966 is a highly selective HDAC3 inhibitor with an IC₅₀ of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM. RGFP966 can penetrate the blood brain barrier (BBB).

HY-103242

CRANAD-2	Amyloid-β	Neurological Disease
CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a K_d of 38 nM .

HY-146334

DFBTA	Chloride Channel	Inflammation/Immunology
DFBTA is an orally active, potent and little brain penetrated ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC₅₀ of 24 nM. DFBTA shows analgesic efficacy for inflammatory pain .

HY-153432

TRV-7019	Cholinesterase (ChE)	Neurological Disease
TRV-7019 is a BBB-penetrable radioligand for brain imaging that target butyrylcholinesterase. TRV-7019 can be used for the diagnosis of an amyloid disease, multiple sclerosis, a brain tumor, or butyrylcholinesterase activity .

HY-145888

Antioxidant agent-2	Amyloid-β	Neurological Disease
Antioxidant agent-2 (comp 3c), an BBB-penetrated antioxidant agent and a selective metal ions chelator, presents good neuroprotective effect and hepatoprotective effect for the study of Alzheimer’s disease .

HY-106578

Quinupramine LM 208	Others	Neurological Disease
Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system[1][2].

HY-147681

SUN13837	FGFR	Neurological Disease
SUN13837 is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. SUN13837 shows neuroprotective activity. SUN13837 can be used for neurodegenerative diseases research .

HY-120085

PFE-360 2 Publications Verification PF-06685360	LRRK2	Neurological Disease
PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC₅₀ of 2.3 nM in vivo .

HY-131703

UGT8-IN-1	UGT	Metabolic Disease
UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 can be used in the study for lysosomal storage disorders .

Cat. No.	Product Name	Type

HY-124171

Zinquin ethyl ester	Fluorescent Dyes/Probes
Zinquin ethyl ester is a fluorescent derivative of Zinquin and is a fluorescent probe of cytosolic zinc. Zinquin ethyl ester is able to penetrate cell membranes and is lipophilic and zinc-sensitive. Zinquin ethyl ester can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence .

HY-D2208

SYTM Green	Fluorescent Dyes/Probes
SYTM Green is a permeable DNA dye that fluoresces green by binding to dsDNA. SYTM Green can also be used to stain bacteria, including Gram-positive and Gram-negative bacteria. Note: SYTM Green cannot penetrate living cells, and this product is equivalent to SYTOX Green .

HY-101879

Acridine Orange hydrochloride 15+ Cited Publications	Fluorescent Dyes/Probes
Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .

HY-114958

RH 421

Fluorescent Dyes/Probes

RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

HY-D0942

Acridine Orange zinc chloride salt Euchrysine 3RX	DNA Stain
Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .

HY-D2268

QM-FN-SO3	Fluorescent Dyes/Probes
QM-FN-SO₃ is a BBB-penetrable near-infrared (NIR) aggregation-induced emission (AIE)-active probe for Aβ plaques. QM-FN-SO₃ can be used for in vivo detection of Aβ plaques. QM-FN-SO₃ has ultra-high S/N ratio, binding affinity, and high-performance NIR emission .

HY-D1726

8RK59	Fluorescent Dyes/Probes
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .

HY-D1346

610CP	Fluorescent Dyes/Probes
610CP is a new type of actin labeling dye. It dissolves in organic solvents. In DMSO the 610CP excitation/emission wavelength is between 609 and 634 nm. 610CP is a fluorescent dye that penetrates living cells. Upon cell entry, 610CP binds to Bromo-des-methyl-Jasplakinolide Therefore, 610CP dye can be used to stain actin fluorescence images with low background and high resolution.

HY-D2268A

QM-FN-SO3 ammonium	Fluorescent Dyes/Probes
QM-FN-SO₃ ammonium is a BBB-penetrable near-infrared (NIR) aggregation-induced emission (AIE)-active probe for Aβ plaques. QM-FN-SO₃ ammonium can be used for in vivo detection of Aβ plaques. QM-FN-SO₃ ammonium has ultra-high S/N ratio, binding affinity, and high-performance NIR emission .

HY-D0079

Dihydroethidium

50+ Cited Publications

Hydroethidine; PD-MY 003

Fluorescent Dyes/Probes

Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .

HY-D0938

CFDA-SE

Maximum Cited Publications

53 Publications Verification

CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester

Fluorescent Dyes/Probes

CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus . CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells .

Cat. No.	Product Name	Type

HY-158082D

TRITC-dextran, MW 150000

Tetramethyl rhodamine isothiocyanate glucan, MW 150000

Cell Assay Reagents

TRITC-dextran, MW 150000 (Tetramethyl rhodamine isothiocyanate glucan, MW 150000) is a fluorescent dye, with the molecular weight of 150 kD. TRITC-dextran, MW 150000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 150000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 150000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082E

TRITC-dextran, MW 500000

Tetramethyl rhodamine isothiocyanate glucan, MW 500000

Cell Assay Reagents

TRITC-dextran, MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) is a fluorescent dye, with the molecular weight of 500 kD. TRITC-dextran, MW 500000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 500000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 500000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082H

TRITC-dextran, MW 2000000

Tetramethyl rhodamine isothiocyanate glucan, MW 2000000

Cell Assay Reagents

TRITC-dextran, MW 2000000 (Tetramethyl rhodamine isothiocyanate glucan, MW 2000000) is a fluorescent dye, with the molecular weight of 2000 kD. TRITC-dextran, MW 2000000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 2000000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 2000000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082

TRITC-dextran, MW 4000

Tetramethyl rhodamine isothiocyanate glucan, MW 4000

Cell Assay Reagents

TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082A

TRITC-dextran, MW 20000

Tetramethyl rhodamine isothiocyanate glucan, MW 20000

Cell Assay Reagents

TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082B

TRITC-dextran, MW 40000

Tetramethyl rhodamine isothiocyanate glucan, MW 40000

Cell Assay Reagents

TRITC-dextran, MW 40000 (Tetramethyl rhodamine isothiocyanate glucan, MW 40000) is a fluorescent dye, with the molecular weight of 40 kD. TRITC-dextran MW 40000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 40000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 40000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082C

TRITC-dextran, MW 70000 Tetramethyl rhodamine isothiocyanate glucan, MW 70000	Cell Assay Reagents
TRITC-dextran, MW 70000 (Tetramethyl rhodamine isothiocyanate glucan, MW 70000) is a fluorescent dye, with the molecular weight of 70 kD. TRITC-dextran, MW 70000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 70000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-D0873

HEPPS EPPS	Biochemical Assay Reagents
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier .

HY-125920

Lauroylsarcosine sodium

Biochemical Assay Reagents

Lauroylsarcosine sodium is a surfactant commonly used in personal care and cosmetics such as shampoos, facial cleansers and toothpaste. It works by lowering the surface tension of water, allowing it to better penetrate and clean surfaces. Lauroylsarcosine sodium is considered safe for cosmetic use and is approved for use in several countries. However, it can cause skin irritation in high concentrations or with prolonged exposure.

HY-D0942

Acridine Orange zinc chloride salt Euchrysine 3RX	DNA Stain
Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .

HY-W250178

Octaethylene glycol monodecyl ether

Biochemical Assay Reagents

Octaethylene glycol monodecyl ether, is a nonionic surfactant commonly used in various industrial and research applications. It belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in lotions, detergents and solubilizers. Octaethylene glycol monodecyl ether is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. In addition, Octaethylene glycol monodecyl ether has the ability to interact with and penetrate cell membranes, so it has potential applications in drug delivery and other medical fields.

HY-W250176

Polyethylene glycol trimethylnonyl ether

Biochemical Assay Reagents

Polyethylene glycol trimethylnonyl ether, is a nonionic surfactant commonly used in various industrial and research applications. It belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in lotions, detergents and solubilizers. Polyethylene glycol trimethylnonyl ether is particularly useful in protein chemistry, where it is used to solubilize and stabilize proteins, such as membrane proteins, for structural analysis techniques. In addition, Polyethylene glycol trimethylnonyl ether has potential applications in drug delivery and other medical fields due to its ability to interact with and penetrate cell membranes.

HY-W250171

Octaethylene glycol monohexadecyl ether

Polyoxyethylene (10) cetyl ether

Biochemical Assay Reagents

Octaethylene glycol monohexadecyl ether, is a nonionic surfactant commonly used in various industrial and research applications. Octaethylene glycol monohexadecyl ether belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail, suitable for use in lotions, detergents and solubilizers. Octaethylene glycol monohexadecyl ether is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. In addition, Octaethylene glycol monohexadecyl ether has the ability to interact with and penetrate cell membranes, so it has potential applications in drug delivery and other medical fields.

HY-W250187

DDMAB

Biochemical Assay Reagents

DDMAB, or didodecyldimethylammonium bromide, is a cationic surfactant commonly used in a variety of industrial and research applications. It belongs to the family of quaternary ammonium compounds and has a positively charged head and a hydrophobic tail, which allows it to be used as a detergent, emulsifier and antimicrobial. Known for its ability to disrupt cell membranes, DDMAB is commonly used in microbiology to selectively isolate and identify bacteria. It is also used in nanotechnology to synthesize metal nanoparticles and other materials. In addition, DDMAB has the ability to interact with and penetrate cell membranes, which has potential applications in drug delivery, gene therapy, and other medical fields.

HY-Y0320

Dimethyl sulfoxide

90+ Cited Publications

DMSO

Co-solvents

Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

HY-W002004

4-Amino-tempo

4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl

Biochemical Assay Reagents

4-Amino-TEMPO can be used as a spin label for detecting radicals and the damage caused by them. 4-Amino-TEMPO possesses superoxide dismutase-mimetic activity, enabling it to easily penetrate cells and protect them from oxidative damage induced by H₂O₂. Additionally, 4-Amino-TEMPO exhibits significant radiation protective properties, effectively safeguarding DNA from oxidative stress-induced damage caused by UV exposure due to its ability to maintain a positive charge. Furthermore, 4-Amino-TEMPO is a highly selective oxidation catalyst widely used in the research and development of various specialty chemicals, including fragrances, pesticides, and others .

Cat. No.	Product Name	Target	Research Area

HY-P2297A

TfR-T12 TFA

Transferrin Receptor Metabolic Disease

TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

HY-P10235

Cyclic AC253	Amylin Receptor	Neurological Disease
Cyclic AC253 is an antagonist for amylin receptor, with IC₅₀ of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB) .

HY-P2342

Angiopep-Bim BH3 hydrochloride	Peptides	Neurological Disease
Angiopep-Bim BH3 hydrochloride, a BBB penetrated peptode, could be used to investigate the permeability of CNS therapeutics .

HY-P4708

Excitin 1

Peptides Neurological Disease

Excitin 1 is an orally active and CNS-penetrated peptide, alters behavior and brain monoamine and amino acid concentrations in rats .
HY-P2297

TfR-T12

Transferrin Receptor Metabolic Disease

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
HY-P5918

Galanin-B2

NAX-5055
Peptides Neurological Disease

Galanin-B2 (NAX-5055) has activity in the epilepsy model. Galanin-B2 can penetrate the blood-brain-barrier .

HY-P4247

Hexaarginine	Peptides	Others
Hexa-arginine, consisting of six arginines, is a polycationic peptide that can penetrate cells efficiently and is mainly used for the intracellular delivery of low-molecular-weight agents, biomolecules, and particles .

HY-P1421

Obestatin(human)	Peptides	Metabolic Disease
Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss. Obestatin(human) cannot penetrate the cell membrane .

HY-P10216

CAQK peptide	Peptides	Others
CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-P3223

Biphalin TFA	Opioid Receptor	Neurological Disease
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P10356

T100-Mut	Peptides	Others
T100-Mut is a cell-permeable peptide whose N-terminus is conjugated with a myristoylated group, allowing it to penetrate and localize to the intracellular side of the plasma membrane, thus mimicking the topology of Tmem100-3Q. T100-Mut can alleviate TRPA1-mediated pain .

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Antibody-Drug Conjugates (ADCs)	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

HY-105066

Davunetide 1 Publications Verification	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

HY-P2358

PSMα3	Toll-like Receptor (TLR)	Inflammation/Immunology
PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) .

HY-P2358A

PSMα3 TFA	Peptides	Inflammation/Immunology
PSMα3 TFA is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 TFA penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 TFA is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) .

HY-P5910

Azurin p28 peptide	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P5982

PTPσ Inhibitor, ISP	Phosphatase	Neurological Disease
PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .

HY-P3492

SARS-CoV-2-IN-34	SARS-CoV	Infection
SARS-CoV-2-IN-34 (S-20-1) is a blood brain barrier penetrable pan-coronavirus (CoV) fusion inhibitor with broad-spectrum inhibitory activity. SARS-CoV-2-IN-34 effectively inhibits infection by pseudotyped and authentic SARS-CoV-2, and pseudotyped variants of concern (VOCs). SARS-CoV-2-IN-34 shows high affinity to RBD in S1 and HR1 domain in S2 of SARS-CoV-2 S protein. SARS-CoV-2-IN-34 can be used for the research of infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011704A

Phosphoenolpyruvic acid tricyclohexylammonium salt	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphoenolpyruvic acid tricyclohexylammonium salt is a glycolysis metabolite with a high-energy phosphate group, penetrates the cell membrane and exhibits cytoprotective and anti-oxidative activity .

HY-N1501

Beta-asarone 2 Publications Verification	Acorus tatarinowii Schott Simple Phenylpropanols Araceae Source classification Phenylpropanoids Plants	Others
Beta-asarone is a major ingredient of Acorus tatarinowii Schott, penetrates blood brain barrier, with the properties of immunosuppression, central nervous system inhibition, sedation, and hypothermy. Beta-asarone protects against Parkinson’s disease .

HY-N4134

Ciwujianoside C3	Structural Classification Natural Products Acanthopanax henryi (Oliv.) Harms Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NO Synthase
Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory .

HY-B1150

Clofoctol	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Antiviral Anticancer Disease Research Fields	Bacterial SARS-CoV Antibiotic
Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency .

HY-N0307

Ciwujianoside B	Triterpenes Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Bcl-2 Family
Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation .

HY-P2358

PSMα3	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR)
PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) .

HY-121618

α-Thujone	Infection Other Monoterpenes Platycladus orientalis (Linn.) Franco Cupressaceae Classification of Application Fields Neurological Disease Terpenoids Source classification Plants Disease Research Fields	GABA Receptor Reactive Oxygen Species Parasite Apoptosis Autophagy
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC₅₀ for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier .

HY-Y0320

Dimethyl sulfoxide 90+ Cited Publications DMSO	Microorganisms Source classification	Bacterial Cholinesterase (ChE)
Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties . MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

Cat. No.	Product Name	Chemical Structure

HY-17412S1

Minocycline-d6 sulfate
Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally effective semi-synthetic tetracycline antibiotic and HIF-1α inhibitor that can penetrate the blood-brain barrier. Minocycline has bacteriostatic, anti-cancer, anti-inflammatory, neuroprotective properties and antidepressant effects.

HY-19939S

VX-984 4 Publications Verification
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-14136S

Rimonabant-d10
Rimonabant-d₁₀ is deuterium labeled Rimonabant. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-109502S

10-OH-NBP-d4
10-OH-NBP-d₄ is deuterium labeled 10-OH-NBP. 10-OH-NBP is a Butylphthalide (3-n-Butylphthalide; NBP; HY-B0647) hydroxylated metabolite and can penetrates the blood-brain barrier (BBB). Butylphthalide exerts neuroprotective effects and has potential for cerebral ischemia research[1].

HY-B0250S

Lamivudine-15N,d2
Lamivudine- ¹⁵N,d₂ is ¹⁵N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-12678S

Entrectinib-d4

Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC₅₀ values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

HY-103309S

ML218-d9

ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

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