BTK<sup> C481S </sup> Ba/F3

By Targets:	5 alpha Reductase (2) 5-HT Receptor (5) Acetolactate Synthase (ALS) (1) ADC Antibody (3) ADC Cytotoxin (1) ADC Linker (1) Adenosine Receptor (1) Adrenergic Receptor (10) Akt (1) Aldose Reductase (1) Amino Acid Derivatives (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (4) Androgen Receptor (3) Angiotensin Receptor (2) Antibiotic (34) Apical Sodium-Dependent Bile Acid Transporter (2) Apoptosis (69) Arrestin (3) Aurora Kinase (1) Autophagy (59) Bacterial (53) Bcl-2 Family (1) Bcr-Abl (8) BCRP (2) Biochemical Assay Reagents (2) BMX Kinase (2) Bombesin Receptor (2) Btk (164) c-Fms (1) c-Kit (3) c-Met/HGFR (1) Calcineurin (1) Calcium Channel (21) Cannabinoid Receptor (3) Carbonic Anhydrase (1) CCR (2) CDK (2) Chloride Channel (1) COX (11) CRISPR/Cas9 (1) Cytochrome P450 (3) Dengue virus (2) Dipeptidyl Peptidase (4) DNA/RNA Synthesis (53) Dopamine Receptor (1) Drug Metabolite (6) Dynamin (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (3) EAAT (1) EGFR (13) Elastase (1) Endogenous Metabolite (420) Estrogen Receptor/ERR (7) Factor Xa (1) Ferroptosis (20) FGFR (4) FKBP (1) Flavivirus (3) FLT3 (7) Fluorescent Dye (3) Fungal (5) FXR (1) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (5) Gap Junction Protein (1) Glucocorticoid Receptor (2) Glutathione Reductase (1) Glutathione S-transferase (1) GlyT (1) GnRH Receptor (1) GSK-3 (1) HBV (5) HCV (6) HCV Protease (1) HDAC (1) Hexokinase (2) HIF/HIF Prolyl-Hydroxylase (7) Histamine Receptor (1) Histone Acetyltransferase (1) Histone Demethylase (1) HIV (17) HIV Integrase (1) HIV Protease (1) HMG-CoA Reductase (HMGCR) (1) HPV (2) HSV (8) IFNAR (1) iGluR (9) IKK (2) Imidazoline Receptor (2) Influenza Virus (12) Interleukin Related (3) IRAK (2) Isotope-Labeled Compounds (532) Itk (4) JAK (14) Keap1-Nrf2 (2) Leukotriene Receptor (2) Ligands for E3 Ligase (7) Ligands for Target Protein for PROTAC (5) Lipoxygenase (1) mAChR (6) MALT1 (1) MEK (1) mGluR (12) MicroRNA (28) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mitophagy (6) MNK (1) Molecular Glues (4) Monoamine Oxidase (1) mTOR (1) Na+/K+ ATPase (2) NADPH Oxidase (1) Neprilysin (2) NF-κB (8) NO Synthase (12) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (48) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (8) P-glycoprotein (1) P2Y Receptor (2) PAK (2) Parasite (17) PARP (1) PDGFR (6) Phosphatase (5) Phosphodiesterase (PDE) (2) Phospholipase (1) PKC (3) Polo-like Kinase (PLK) (2) Potassium Channel (9) PPAR (2) Progesterone Receptor (6) Prostaglandin Receptor (2) PROTAC Linkers (5) PROTACs (14) Proton Pump (1) Pyroptosis (1) Raf (3) RANKL/RANK (1) RAR/RXR (1) Reactive Oxygen Species (26) RET (4) Reverse Transcriptase (4) RSV (2) SARS-CoV (14) Serotonin Transporter (2) Sirtuin (3) Small Interfering RNA (siRNA) (11) Sodium Channel (9) Src (2) STAT (2) TAM Receptor (1) TGF-beta/Smad (3) Thrombin (3) Thrombopoietin Receptor (1) Thymidylate Synthase (1) Thyroid Hormone Receptor (6) Toll-like Receptor (TLR) (3) Topoisomerase (3) Transketolase (1) Trk Receptor (7) TRP Channel (3) Tyrosinase (1) VD/VDR (3) VEGFR (7) Virus Protease (1)
By Research Areas:	Cancer (380) Cardiovascular Disease (44) Endocrinology (30) Infection (117) Inflammation/Immunology (137) Metabolic Disease (204) Neurological Disease (97)
Click Chemistry:	Labeling and Fluorescence Imaging (2) PROTAC Synthesis (2) Azide (2) Tetrazine (1) Alkynes (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70134

Endo-β-N-acetylglucosaminidase F3 Endo F3	Others	Metabolic Disease
Endo-β-N-acetylglucosaminidase D (Endo F3) cleaves free or Asparagine-linked triantennary oligosaccharides or α1-6 fucosylated biantennary oligosaccharides, as well as triamnnosyl chitobiose core structures .

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-147580

BTK-IN-10

Btk Cancer

BTK-IN-10 is a potent BTK inhibitor with IC₅₀s of <5 nM for wild-type BTK or mutated BTK (C481S), respectively (WO2022012509A1; example 111) .

BTK-IN-10	Btk	Cancer
BTK-IN-10 is a potent *BTK* inhibitor with IC₅₀s of <5 nM for wild-type BTK or mutated BTK (C481S), respectively (WO2022012509A1; example 111) .

HY-RS04643

F3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
F3 Human Pre-designed siRNA Set A contains three designed siRNAs for F3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

F3 Human Pre-designed siRNA Set A F3 Human Pre-designed siRNA Set A

HY-147582

BTK-IN-12

Btk Cancer

BTK-IN-12 is a potent BTK inhibitor with IC₅₀s of 1.2 nM and 0.8 nM for wild-type BTK or mutated BTK (C481S), respectively (WO2022037649A1; compound 8) .

BTK-IN-12	Btk	Cancer
BTK-IN-12 is a potent *BTK* inhibitor with IC₅₀s of 1.2 nM and 0.8 nM for wild-type BTK or mutated BTK (C481S), respectively (WO2022037649A1; compound 8) .

HY-P99271

Tisotumab Anti-Human F3 Recombinant Antibody	ADC Antibody	Cancer
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody targets tissue factor (TF). Tisotumab can be used for the research of solid tumors .

HY-153705

BTK-IN-25	Btk	Cancer
BTK-IN-25 (compound 71) is a potent inhibitor of *BTK, and inhibits BTK(C481S) with an IC₅₀* value of 0.77 nM. BTK-IN-25 inhibits BTK in DOHH2 cells with an IC₅₀ value of 1 nM .

HY-153951S

BTK-IN-26	Btk	Inflammation/Immunology Cancer
BTK-IN-26 (compound 18) is a potent inhibitor of Bruton's tyrosine kinase (BTK) and its C481 mutant, with IC₅₀ values of 0.7 and 0.8 nM for *BTK* and **BTK C481S*, respectively. BTK*-IN-26 can be used for cancer and autoimmune diseases research .

HY-151211

BTK-IN-16	Btk	Inflammation/Immunology Cancer
BTK-IN-16 is a dual inhibitor of BTK wild type and C481S mutant of Bruton’s tyrosine kinase (BTK) with IC₅₀s of 5.1 and 4.1 μM. BTK-IN-16 can be used for the research of autoimmune diseases and chronic lymphocytic leukemia .

HY-153220

NX-2127	Btk	Cancer
NX-2127 is an orally and potent *BTK* inhibitor, inducing degradation of the mutated BTK ^C481S in cells. NX-2127 inhibits proliferation of BTK ^C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells .

HY-144170

RET-IN-14	RET Btk	Cancer
RET-IN-14 (compound 49) is a potent RET inhibitor with IC₅₀s of <0.51 nM, 9.3 nM, 1.3 nM, 9.2 nM, 15 nM for RET (WT), RET (G810R), RET (V804M), BTK and BTK (C481S), respectively. RET-IN-14 has the potential for tumors research

HY-130983

N-piperidine Ibrutinib hydrochloride	Btk Ligands for Target Protein for PROTAC	Cancer
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent *BTK* inhibitor with IC₅₀s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively . N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC₅₀ of 7.9 nM .

HY-112215

Nemtabrutinib 1 Publications Verification ARQ-531; MK-1026	Btk	Inflammation/Immunology Cancer
ARQ 531 (MK-1026) is a reversible non-covalent and orally active inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC₅₀s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

HY-122562

MT-802 1 Publications Verification	PROTACs Btk	Inflammation/Immunology Cancer
MT-802 is a potent *BTK* degrader based on Cereblon ligand, with a DC₅₀ of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL) .

HY-136531

XMU-MP-3	Btk Apoptosis	Cancer
XMU-MP-3 is a potent non-covalent *BTK* inhibitor with IC₅₀s of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation in the presence of 10 μM ATP, respectively. XMU-MP-3 also induces apoptosis .

HY-163366

TRK-IN-28	Trk Receptor	Cancer
TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC₅₀ values of 0.55 nM, 25.1 nM and 5.4 nM against TRK ^WT, TRK ^G595R and TRK ^G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC₅₀ values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA ^WT, Ba/F3-ETV6-TRKB ^WT, Ba/F3-LMNA-TRK ^G595R and Ba/F3-LMNA-TRKA ^G667C, respectively .

HY-19834

Fenebrutinib 5+ Cited Publications GDC-0853	Btk	Cancer
Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with K_is of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research .

HY-B2203

Calcium glycerophosphate	Phosphatase	Metabolic Disease
Calcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3. Calcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions .

HY-18960

CHZ868

5 Publications Verification

JAK Cancer

CHZ868 is a type II JAK2 inhibitor with an IC₅₀ of 0.17 μM in EPOR JAK2 WT Ba/F3 cell.

CHZ868 5 Publications Verification	JAK	Cancer
CHZ868 is a type II JAK2 inhibitor with an IC₅₀ of 0.17 μM in EPOR JAK2 WT Ba/F3 cell.

HY-104010

Asciminib 5 Publications Verification ABL001	Bcr-Abl	Cancer
Asciminib (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC₅₀ of 0.25 nM .

HY-104010A

Asciminib hydrochloride 5 Publications Verification ABL001 hydrochloride	Bcr-Abl	Cancer
Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC₅₀ of 0.25 nM .

HY-149965

TRK-IN-23	Trk Receptor Apoptosis	Cancer
TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC₅₀ values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKA ^G595R, TRKA ^F589L, and TRKA ^G667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells .

HY-163004

Type II TRK inhibitor 2	Trk Receptor	Cancer
Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKA ^G595R and Ba/F3-TRKA ^G667C cell proliferation (IC₅₀: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers .

HY-11007

GNF-2 2 Publications Verification	Bcr-Abl SARS-CoV	Cancer
GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-18952A

(Z)-SU5614	FLT3 Apoptosis	Cancer
(Z)-SU5614 is a potent *FLT3* inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3 .

HY-110026

GTP-14564	FLT3	Cancer
GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and *FLT3*. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells .

HY-156467

ALK-IN-27	Anaplastic lymphoma kinase (ALK)	Cancer
ALK-IN-27 (compound 1) is a potent ALK inhibitor. ALK-IN-27 shows antitumor activity. ALK-IN-27 has an IC₅₀ of 2.7 nM for Ba/F3 CLIP1-LTK cells .

HY-104010R

Asciminib (Standard)	Bcr-Abl	Cancer
Asciminib (Standard) is the analytical standard of Asciminib. This product is intended for research and analytical applications. Asciminib (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC₅₀ of 0.25 nM .

HY-144451

TRK-IN-12	Trk Receptor	Cancer
TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRK ^G595R IC₅₀ = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC₅₀ = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC₅₀ = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line .

HY-107662

TCS PrP Inhibitor 13	Apoptosis	Infection Cancer
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrP ^C) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC₅₀ value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .

HY-13491

GNF-5837 3 Publications Verification	Trk Receptor	Cancer
GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC₅₀ values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) .

HY-12291

HG6-64-1 HMSL 10017-101-1	Raf	Cancer
HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC₅₀ of 0.09 μM on B-raf V600E transformed Ba/F3 cells.

HY-157432

EGFR-IN-97	EGFR Apoptosis	Cancer
EGFR-IN-97 (compound 6q) is a EGFR inhibitor. EGFR-IN-97 shows inhibitory activity against Ba/F3-EGFR ^{L858R/T790M/C797S} and Ba/F3-EGFR ^{Del19/T790M/C797S} cells, with IC₅₀ values of 0.42 μM and 0.41 μM, respectively. EGFR-IN-97 can promote apoptosis of NCI-H1975-EGFR ^{L858R/T790M/C797S} cells at the concentration of 0.8 μM .

HY-142922

BCR-ABL-IN-4	Bcr-Abl	Cancer
BCR-ABL-IN-4 is a BCR-ABL inhibitor with anticancer effects. BCR-ABL-IN-4 inhibits the cancer cell growth with IC₅₀ values of 0.67 nM and 16 nM for K562 cells and BCR-ABL T315I transfected Ba/F3 cells, respectively (WO2021143927A1; compound 11) .

HY-156467A

ALK-IN-27 TFA	Anaplastic lymphoma kinase (ALK)	Cancer
ALK-IN-27 TFA is the TFA form of ALK-IN-27 (HY-156467). ALK-IN-27 (compound 1) is a potent ALK inhibitor. ALK-IN-27 shows antitumor activity. ALK-IN-27 has an IC₅₀ of 2.7 nM for Ba/F3 CLIP1-LTK cells .

HY-12083

PPY-A	Bcr-Abl	Cancer
PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC₅₀s of 9 and 20 nM, respectively. PPY-A inhibits Ba⁄F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC₅₀s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML) .

HY-131244

ALK-IN-9	Anaplastic lymphoma kinase (ALK)	Cancer
ALK-IN-9 (compound 40) is a potent ALK inhibitor. ALK-IN-9 inhibits cell proliferation with IC₅₀s of <0.2 nM, <0.2 nM, 0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), KG-l cell (OP2-FGFR1), respectively .

HY-160167

BTK-IN-30

Btk Inflammation/Immunology

BTK-IN-30 (compound cpd15) is an inhibitor of Bruton's Tyrosine Kinase (BTK) and mutant BTK with IC₅₀ values of 6.72 and 6.11nM respectively .
HY-152201

BTK-IN-18

Btk Cancer

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC₅₀ of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo .
HY-160141

BTK-IN-29

Btk Cancer

BTK-IN-29 (compound 14) is an inhibitor of Btk .
HY-122828

PROTAC BTK Degrader-2

PROTACs Btk Others

PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels .
HY-157763

PROTAC BTK Degrader-8

PROTACs Btk Cancer

PROTAC BTK Degrader-8 (compound 3) is a potent PROTAC BTK degrader .
HY-141689

BTK-IN-3

Btk Cancer

BTK-IN-3 (example 1) is an inhibitor of BTK. BTK-IN-3 can used to study cancer .

BTK-IN-30	Btk	Inflammation/Immunology
BTK-IN-30 (compound cpd15) is an inhibitor of Bruton's Tyrosine Kinase (BTK) and mutant BTK with IC₅₀ values of 6.72 and 6.11nM respectively .

BTK-IN-18	Btk	Cancer
BTK-IN-18 is a potent, reversible *BTK* inhibitor with an IC₅₀ of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo .

BTK-IN-29	Btk	Cancer
BTK-IN-29 (compound 14) is an inhibitor of *Btk* .

*PROTAC BTK* Degrader-2**	PROTACs Btk	Others
PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels .

*PROTAC BTK* Degrader-8**	PROTACs Btk	Cancer
PROTAC BTK Degrader-8 (compound 3) is a potent PROTAC BTK degrader .

BTK-IN-3	Btk	Cancer
BTK-IN-3 (example 1) is an inhibitor of *BTK. BTK*-IN-3 can used to study cancer .

HY-143717

*JAK3/BTK-IN-2*	JAK Btk	Inflammation/Immunology
JAK3/BTK-IN-2 is a potent inhibitor of *JAK3/BTK*. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-2 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 004)

HY-143720

*JAK3/BTK-IN-5*	JAK Btk	Inflammation/Immunology
JAK3/BTK-IN-5 is a potent inhibitor of *JAK3/BTK*. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-5 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, compound 35)

HY-143716

*JAK3/BTK-IN-1*	JAK Btk	Inflammation/Immunology
JAK3/BTK-IN-1 is a potent inhibitor of *JAK3/BTK*. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-1 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 002) .

HY-143718

*JAK3/BTK-IN-3*	JAK Btk	Inflammation/Immunology
JAK3/BTK-IN-3 is a potent inhibitor of *JAK3/BTK*. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-3 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 009)

HY-143719

*JAK3/BTK-IN-4*	JAK Btk	Inflammation/Immunology
JAK3/BTK-IN-4 is a potent inhibitor of *JAK3/BTK*. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-4 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, compound 003)

HY-162081

BTK-IN-32	Btk	Cancer
BTK-IN-32 (compound C2) is a potent inhibitor of *BTK. BTK-IN-32 activates full-length BTK* and smaller multidomain BTK fragments instead of the isolated kinase domain .

HY-101763A

(S,R,S)-AHPC monohydrochloride 1 Publications Verification VH032-NH2 monohydrochloride; VHL ligand 1 monohydrochloride	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC₅₀ of 1.11 μM in Ba/F3 cells .

Cat. No.	Product Name

HY-L129

Target Protein Ligand Library

39 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 39 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L156

Autoimmune Disease Compound Library

461 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 461 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

HY-L009

Kinase Inhibitor Library

2,673 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 2,673 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

HY-L016

Protein Tyrosine Kinase Compound Library

1,064 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,064 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-D1583

Cyanine5 DBCO

1 Publications Verification

DBCO-Cy5; Cyanine5 dibenzocyclooctyne

Fluorescent Dyes/Probes

Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) ^[2].

HY-D1327

Cyanine3 azide chloride

Fluorescent Dyes/Probes

Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λ_ex=684 nm, λ_em=710 nm) ^{[1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.}

Cat. No.	Product Name	Type

HY-157926

Nitroso-PSAP	Chelators
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe ²⁺), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe ²⁺) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) .

HY-158465

GPEP FA2-KVANKT glycopeptide F(3)A2 glycan-KVANKT & F(6)A2 glycan-KVANKT	Carbohydrates
GPEP FA2-KVANKT glycopeptide (F(3)A2 glycan-KVANKT & F(6)A2 glycan-KVANKT) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-110002

LFM-A13	Biochemical Assay Reagents
LFM-A13 is a potent *BTK, JAK2, PLK* inhibitor, inhibits recombinant BTK, Plx1 and PLK3 with IC₅₀s of 2.5 μM, 10 μM and 61 μM. LFM-A13 has antiproliferative activity and anticancer activity. LFM-A13 can be used in cancer-related research ^[3]

Cat. No.	Product Name	Target	Research Area

HY-P1423A

BA 1 TFA	Bombesin Receptor	Metabolic Disease Cancer
BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors. BA1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-108742

Abaloparatide 1 Publications Verification Ba 058; BIM 44058	Thyroid Hormone Receptor Arrestin	Metabolic Disease
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis .

HY-108742A

Abaloparatide TFA 1 Publications Verification Ba 058 TFA; BIM 44058 TFA	Thyroid Hormone Receptor Arrestin	Metabolic Disease Endocrinology
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis .

HY-P1423

BA 1	Bombesin Receptor	Metabolic Disease Cancer
BA 1 is a potent agonist for the bombesin (BB) family of receptors. BA 1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-P4583

Suc-Val-Pro-Phe-SBzl

Peptides Others

Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) is an inhibitor of CatG enzymes with IC₅₀ values of 111-225 mM.

HY-P1604

ATX-II	Sodium Channel	Inflammation/Immunology
ATX-II is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na ^{+sup channel in cell cultures. ATX-II sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .}

HY-P10324

TAT-p16 p16<sup>INK4asup> peptide	Peptides	Cancer
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex .

HY-P1604A

ATX-II TFA	Sodium Channel	Inflammation/Immunology
ATX-II TFA is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na ^{+sup channel in cell cultures. ATX-II TFA sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .}

HY-P0265AS

β-Amyloid-15N (1-40) (TFA) Amyloid Beta-Peptide-<sup>15sup>N (1-40) (human) TFA; Amyloid β-Peptide-<sup>15sup>N (1-40) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid- ¹⁵N (1-40) (TFA) is the ¹⁵N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease[1].

HY-W010452S1

3-Hydroxybutyric acid-13C4 sodium β-Hydroxybutyric acid-<sup>13sup>C₄ sodium	Endogenous Metabolite	Metabolic Disease
3-Hydroxybutyric acid- ¹³C₄ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].

HY-P5340

Amyloid-Forming peptide GNNQQNY	Peptides	Others
Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)

HY-P1363S

β-Amyloid-15N (1-42), human TFA Amyloid β-peptide-<sup>15sup>N (1-42) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid- ¹⁵N (1-42), human (TFA) is the ¹⁵N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease[1].

HY-P10013

Codactide

Ba-41795
Peptides Endocrinology

Codactide is a synthetic octadecapeptide, with corticotropin-like action .

HY-P3973

Thrombostatin cont-1	Peptides	Others
Thrombostatin cont-1 is an analogue of thrombostatin, which is a a bradykinin metabolite. Thrombostatin could decrease platelet activation in the canine carotid artery model of balloon angioplasty (BA) injury .

HY-P5820

ω-Conotoxin Bu8	Calcium Channel	Neurological Disease
ω-Conotoxin Bu8 is a ω-conotoxin, which consists of 25 amino acid residues and three disulfide bridges. ω-Conotoxin Bu8 selectively and potently inhibits depolarization-activated Ba₂₊ currents mediated by rat CaV2.2 expressed in HEK293T cells (IC₅₀= 89 nM) .

HY-108742R

Abaloparatide (Standard)	Thyroid Hormone Receptor Arrestin	Metabolic Disease
Abaloparatide (Standard) is the analytical standard of Abaloparatide. This product is intended for research and analytical applications. Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis .

HY-P5438

Srctide	Peptides	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages ^[3].

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages ^[3].

Cat. No.	Product Name	Target	Research Area

HY-P99271

Tisotumab Anti-Human F3 Recombinant Antibody	ADC Antibody	Cancer
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody targets tissue factor (TF). Tisotumab can be used for the research of solid tumors .

HY-P990222

Anti-Mouse IL-17A Antibody (17F3)

Inhibitory Antibodies Others

Anti-Mouse IL-17A Antibody (17F3) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-17A.

HY-P9988

Mecbotamab Ba301	ADC Antibody TAM Receptor	Cancer
Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE (HY-15162) via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011) .

HY-P990212

Anti-Mouse IL-6 Antibody (MP5-20F3)

Inhibitory Antibodies Others

Anti-Mouse IL-6 Antibody (MP5-20F3) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-6.
HY-P990145

Anti-Mouse VISTA Antibody (13F3)

Inhibitory Antibodies Others

Anti-Mouse VISTA Antibody (13F3) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse VISTA.
HY-145626

Ozuriftamab

Ba302
ADC Antibody Cancer

Ozuriftamab is a naked human IgG1 kappa antibody of receptor tyrosine kinase-like orphan receptor 2 ROR2, can be used to synthesis ADC .
HY-P990411

Anti-F3/Factor III/Tissue Factor/CD142 Antibody

Inhibitory Antibodies Inflammation/Immunology

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0600

Ginsenoside F3	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related IFNAR
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-N0309

Soyasaponin Ba	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Aldose Reductase
Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI) .

HY-N11122

7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol	Structural Classification Natural Products Rhodiola rosea Linn. Source classification Crassulaceae Plants	Others
7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola rosea sup>[1].

HY-N10443

Mammea A/BA	other families Source classification Coumarins Phenylpropanoids Plants Calophyllum brasiliense auct. non Camb.	Parasite Apoptosis Autophagy Reactive Oxygen Species
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-N8824

Maackiaflavanone	Structural Classification Flavonoids Leguminosae Flavonones Source classification Maackia amurensis Rupr. et Maxim. Plants	Others
Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.

HY-N3872

Ethyl β-D-glucopyranoside	Scabiosa stellata L. Structural Classification Natural Products Caprifoliaceae Source classification Plants	Others
Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.

HY-N8859

Isoiridogermanal 16-Hydroxyiridal	Structural Classification Natural Products Source classification Lridaceae Plants	Others
Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 cell lines.

HY-N8930

Eupatorin-5-methyl ether	Structural Classification Galinsoga parviflora Cav. Flavonoids Flavones Labiatae Source classification Plants	Others
Eupatorin-5-methyl ether (TMF) can be isolated from Orthosiphon stamineus. Eupatorin-5-methyl ether is a kind of flavonoid compound. Eupatorin-5-methyl ether inhibits NO production (IC50 5.5 μM).

HY-41700

D-Alanine (R)-Alanine; Ba 2776; D-α-Alanine	Structural Classification Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR .

HY-118384

Sangivamycin 2 Publications Verification NSC 65346; Ba-90912	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an K_i of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-N4080

Cyclobuxine D	other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Steroids	mAChR
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba ⁺⁺−induced contraction of the longitudinal muscle isolated from the rabbit jejunum .

HY-13434

Ionomycin Maximum Cited Publications 51 Publications Verification SQ23377	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) ^[3].

HY-N8448

3,4-Di-O-caffeoyl quinic acid methyl ester Macroantoin F	Structural Classification Source classification Phenols Polyphenols Amorpha fruticosaL. Plants Compositae	RSV
3,4-Di-O-caffeoyl quinic acid methyl ester (Macroantoin F) is a dicaffeoyl derivative isolated from the rhizome of Elephantopus scaber Linn. 3,4-Di-O-caffeoyl quinic acid methyl ester exhibited in vitro antiviral activity against respiratory syncytial virus (< a href=" " class="link-product" target="_blank">RSV) with an IC₅₀ value of 0.78 μg/mL .

HY-113437

1,2-Dipalmitoyl-sn-glycerol 3-phosphate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,2-Dipalmitoyl-sn-glycerol 3-phosphate (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite .

HY-13434A

Ionomycin calcium Maximum Cited Publications 51 Publications Verification SQ23377 calcium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) ^[3].

HY-113437A

1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite . It is used in the generation of micelles, liposomes, and artificial membranes.

Species:	Human (18) Porcine (1) Mouse (4) Rat (2) Cynomolgus (2) Rabbit (1) Canine (1)
Tag:	His (26) SUMO (2) Tag Free (1) Avi (4) GST (2) Fc (1) Flag (1)
Source:	HEK293 (17) Sf9 insect cells (3) P. pastoris (1) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P78592

	Tissue Factor Protein, Cynomolgus (HEK293, His) Coagulation Factor III; Tissue Factor; TF; F3; CD142	Cynomolgus	HEK293
	F3 Protein, a cell surface receptor, plays a significant role in regulating blood coagulation and promoting cell adhesion. Dysregulation of F3 Protein has been associated with various disorders, including thrombosis and cancer. Targeting F3 Protein may offer potential therapeutic interventions in these conditions by inhibiting blood clot formation and preventing tumor cell adhesion and metastasis. Tissue Factor Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Cynomolgus (HEK293, His) is 220 a.a., with molecular weight of approximately 34-50 kDa.

HY-P73592

	Tissue Factor Protein, Rat (HEK293, His) CD142; Coagulation Factor III; F3; TF; TFA; Tissue Factor	Rat	HEK293
	Tissue Factor Protein plays a critical role in blood coagulation. It binds to coagulation factors, activating clotting cascades. Tissue Factor Protein interacts with cells, promoting thrombosis and inflammation. Understanding its functions can aid in developing treatments for blood disorders and cardiovascular diseases. Tissue Factor Protein, Rat (HEK293, His) is the recombinant rat-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Rat (HEK293, His) is 252 a.a., with molecular weight of 47-52 kDa.

HY-P73594

	Tissue Factor Protein, Rabbit (HEK293, His) CD142; Coagulation Factor III; F3; TF; TFA; Tissue Factor	Rabbit	HEK293
	Tissue Factor Protein initiates blood coagulation by binding to coagulation factors. It activates clotting cascades and interacts with cells to promote thrombosis and inflammation. Understanding Tissue Factor Protein's functions is crucial for developing treatments for cardiovascular diseases and blood disorders. Tissue Factor Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Rabbit (HEK293, His) is 218 a.a., with molecular weight of ~26.4 kDa.

HY-P74224

	Contactin-1/CNTN1 Protein, Mouse (HEK293, His) CNTN1; Contactin1; F11; F3; Neural cell surface protein F3	Mouse	HEK293
	Contactin-1/CNTN1 protein mediates surface interactions during nervous system development. It forms paranodal axo-glial junctions in peripheral nerves and facilitates axon-glia signaling through CNTNAP1. It acts as a ligand for NOTCH1, promoting NOTCH1 activation. Contactin-1/CNTN1 also interacts with TNR, inhibiting neurite outgrowth. It binds to CNTNAP1 and PTPRZ1, and forms a complex with NRCAM, PTPRB, and TASOR. Contactin-1/CNTN1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Contactin-1/CNTN1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Contactin-1/CNTN1 Protein, Mouse (HEK293, His) is 1000 a.a., with molecular weight of 110-120 kDa.

HY-P700695

	Coagulation Factor III/F3 Protein, Canine (HEK293, His) Tissue factor; Coagulation Factor III; TF; Thromboplastin; CD142; F3; FLJ17960; TFA	Canine	HEK293
	Coagulation Factor III (F3), or Tissue Factor (TF), initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex critically activates factors IX or X through limited proteolysis, initiating the coagulation cascade on the cell surface. F3's interaction with HSPE, inhibited by heparin, promotes the generation of activated factor X, emphasizing its central role in regulating hemostatic processes. Coagulation Factor III/F3 Protein, Canine (HEK293, His) is the recombinant canine-derived Coagulation Factor III/F3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor III/F3 Protein, Canine (HEK293, His) is 214 a.a., with molecular weight of 35-45 kDa.

HY-P7787

	Tissue Factor Protein, Human (HEK293, His) rHuCD142, His; Tissue Factor; TF; Coagulation Factor III; Thromboplastin; CD142; F3	Human	HEK293
	Tissue Factor Protein, Human (HEK293, His) is a recombinant human CD142 expressed in HEK 293 cells with a His tag at the N-terminus. Coagulation Factor III/CD142 Protein is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process.

HY-P7787A

	Tissue Factor Protein, Human (HEK293, Fc) rHuCD142, His; Tissue Factor; TF; Coagulation Factor III; Thromboplastin; CD142; F3	Human	HEK293
	Tissue Factor Protein, Human (HEK293, Fc) is a recombinant human CD142 expressed in HEK 293 cells with a His tag at the N-terminus. Coagulation Factor III/CD142 Protein is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process.

HY-P702730

BTK Protein, Human (Biotinylated, sf9, His, Avi)

BTK; Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK
Human Sf9 insect cells

HY-P73634

	SNAP25 Protein, Human (His) Synaptosomal-associated protein 25; SNAP-25; sup; SNAP	Human	E. coli
	SNAP25 is a key t-SNARE in neurotransmitter release, regulating synaptic function and plasma membrane recycling. It cooperates with CENPF to affect vesicle docking and membrane fusion. SNAP25 Protein, Human (His) is the recombinant human-derived SNAP25 protein, expressed by E. coli , with N-His labeled tag. The total length of SNAP25 Protein, Human (His) is 206 a.a., with molecular weight of ~28 kDa.

HY-P76804

	CD42b/GP1BA Protein, Human (519a.a, HEK293, His) Platelet glycoprotein Ib alpha; GP1Ba	Human	HEK293
	CD42b/GP1BA protein is an important platelet membrane protein that interacts with the A1 domain of von Willebrand factor and contributes to the formation of subendothelial platelet plugs. Its GP1BA subunit forms a disulfide-linked complex with two GP1BB subunits, collectively called GP-Ib. CD42b/GP1BA Protein, Human (519a.a, HEK293, His) is the recombinant human-derived CD42b/GP1BA protein, expressed by HEK293 , with C-His labeled tag. The total length of CD42b/GP1BA Protein, Human (519a.a, HEK293, His) is 503 a.a., with molecular weight of ~93 kDa.

HY-P72048

	BTK Protein, Human (Baculovirus, His) Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton Tyrosine Kinase; BTK; BTK_HUMAN; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP00000063593; PSCTK 1; PSCTK1; truncated Bruton agammaglobulinemia tyrosine kinase; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; tyrosine-protein kinase BTK isoform lacking exon 14; XLA	Human	Sf9 insect cells
	The BTK protein is a key non-receptor tyrosine kinase that is essential for B lymphocyte development and signaling. After BCR activation, BTK initiates a cascade reaction, phosphorylates PLCG2 and activates downstream pathways, affecting calcium mobilization and PKC activation. BTK Protein, Human (Baculovirus, His) is the recombinant human-derived BTK protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of BTK Protein, Human (Baculovirus, His) is 659 a.a., with molecular weight of ~78.3 kDa.

HY-P73934

	Haptoglobin Protein, Rat (HEK293, His) Haptoglobin; Zonulin; HP; Ba1-647	Rat	HEK293
	Haptoglobin Proteinas, a positive regulator of collagen fibrillogenesis, likely plays a crucial role in extracellular matrix organization and remodeling. Its involvement extends to positively regulating MAP-kinase activity, contributing to increased adipocyte proliferation and diminished differentiation. Haptoglobin may also serve as a positive regulator of NF-kappa-B activity in macrophages, enhancing inflammatory responsiveness. Additionally, it exhibits transcriptional repressor activity, suggesting its role in gene expression modulation. Haptoglobin Protein, Rat (HEK293, His) is the recombinant rat-derived Haptoglobin protein, expressed by HEK293, with C-His labeled tag. The total length of Haptoglobin Protein, Rat (HEK293, His) is 347 a.a., with molecular weight of ~38.1 kDa.

HY-P77951

	CD42b/GP1BA Protein, Human (515a.a, HEK293, His) GP-Ib alpha; GPIb-alpha; GPIBa; GP1Ba; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; VWDP; BP1Ba; MGC34595	Human	HEK293
	CD42b/GP1BA protein is an important platelet membrane protein that interacts with the A1 domain of von Willebrand factor and contributes to the formation of subendothelial platelet plugs. Its GP1BA subunit forms a disulfide-linked complex with two GP1BB subunits, collectively called GP-Ib. CD42b/GP1BA Protein, Human (515a.a, HEK293, His) is the recombinant human-derived CD42b/GP1BA protein, expressed by HEK293 , with C-His labeled tag. The total length of CD42b/GP1BA Protein, Human (515a.a, HEK293, His) is 515 a.a., with molecular weight of 100-130 kDa.

HY-P700598

	BTK Protein, Human (P. pastoris, His) Agammaglobulinemia tyrosine kinase ; ATKB-cell progenitor kinase ; BPKBruton tyrosine kinase	Human	P. pastoris
	BTK Protein, a key non-receptor tyrosine kinase, is essential for B lymphocyte development and signaling. Upon BCR activation, BTK initiates a cascade, phosphorylating PLCG2 and activating downstream pathways, influencing calcium mobilization and PKC activation. In innate and adaptive immunity, particularly TLR pathways, BTK regulates TLR9 activation, induces NF-kappa-B activity, and activates NLRP3 inflammasome assembly. Its multifaceted functions include phosphorylating GTF2I, participating in apoptosis regulation, and serving as a platform for diverse signaling proteins. BTK Protein, Human (P. pastoris, His) is the recombinant human-derived BTK protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of BTK Protein, Human (P. pastoris, His) is 659 a.a., with molecular weight of 78.2 kDa.

HY-P7752

	Cathepsin H Protein, Mouse (HEK293, His) rMuCathepsin H, His; Pro-cathepsin H; CTSH; ACC-4; ACC-5; aleurain; cathepsin B3; cathepsin Ba; cathepsin H; CPSB;	Mouse	HEK293
	Cathepsin H Protein, Mouse (HEK293, His) is an approximately 36-40 kDa cathepsin H protein with a His-flag. Cathepsin H is a lysosomal cysteine protease of the papain family.

HY-P72137

	CFB Protein, Mouse (His) 1 Publications Verification Cfb; Bf; H2-BfComplement factor B; EC 3.4.21.47; C3/C5 convertase; Complement factor B Ba fragment; Complement factor B Bb fragment	Mouse	E. coli
	CFB is an important component of the alternative pathway of the complement system and is cleaved by factor D, producing two fragments: Ba and Bb. The Bb fragment is characterized as a serine protease and subsequently forms a complex with complement factor 3b, ultimately producing a C3 or C5 convertase. CFB Protein, Mouse (His) is the recombinant mouse-derived CFB protein, expressed by E. coli , with N-6*His labeled tag. The total length of CFB Protein, Mouse (His) is 739 a.a., with molecular weight of ~87 kDa.

HY-P77749

	MFG-E8 Protein, Mouse (HEK293, His) Lactadherin; MFGM; MFG-E8; SED1; MP47; Ba46; EDIL1; HsT19888; Medin; MFG1; OAcGD3S; SPAG10	Mouse	HEK293
	The MFG-E8 protein plays a critical role in promoting the phagocytic clearance of apoptotic cells in various tissues. As a specific ligand, it interacts with alpha-v/beta-3 and alpha-v/beta-5 receptors and also binds independently to phosphatidylserine-rich cell surfaces. MFG-E8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MFG-E8 protein, expressed by HEK293 , with N-His labeled tag. The total length of MFG-E8 Protein, Mouse (HEK293, His) is 441 a.a., with molecular weight of 60-70 kDa.

HY-P70170

	Fetuin A/AHSG Protein, Human (HEK293, His) rHuAlpha-2-HS-glycoprotein/AHSG, His; Alpha-2-HS-Glycoprotein; Alpha-2-Z-Globulin; Ba-Alpha-2-Glycoprotein; Fetuin-A; AHSG; FETUA	Human	HEK293
	Fetuin A (or AHSG protein) plays multiple roles in cellular processes, promotes endocytosis and displays opsonic properties. It regulates the mineral phase of bone, affects bone homeostasis, and has significant affinity for calcium and barium ions. Fetuin A/AHSG Protein, Human (HEK293, His) is the recombinant human-derived Fetuin A/AHSG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fetuin A/AHSG Protein, Human (HEK293, His) is 349 a.a., with molecular weight of ~60.0 kDa.

HY-P71580

	GFRAL Protein, Human (His-SUMO) Ba360D14.1; C6orf144; GDNF family receptor alpha-like; Gfral; GFRAL_HUMAN; GRAL; IVFI9356; UNQ9356; UNQ9356/PRO34128	Human	E. coli
	The GFRAL protein is a brainstem-restricted receptor for GDF15 that regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. GFRAL binds to its ligand GDF15, interacts with RET, and activates the MAPK and AKT signaling pathways. GFRAL Protein, Human (His-SUMO) is the recombinant human-derived GFRAL protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GFRAL Protein, Human (His-SUMO) is 333 a.a., with molecular weight of ~53.8 kDa.

HY-P78521

	SIRP gamma Protein, Human (HEK293, His-Avi) CD172g; FLJ42230; SIRP beta 2; SIRP gamma; SIRP-B2; SIRPG; Cripto-1; Ba77C3.1; SIRP β 2	Human	HEK293
	SIRP γ protein is a possible immunoglobulin-like cell surface receptor that mediates cell-cell adhesion by binding to CD47. This interaction enhances antigen-specific T cell proliferation and provides costimulatory signals for T cell activation, highlighting the role of SIRP gamma in regulating immune responses. SIRP gamma Protein, Human (HEK293, His-Avi) is the recombinant human-derived SIRP gamma protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P78210

	SIRP gamma Protein, Human (Biotinylated, HEK293, His-Avi) CD172g; FLJ42230; SIRP beta 2; SIRP gamma; SIRP-B2; SIRPG; Cripto-1; Ba77C3.1; SIRP β 2	Human	HEK293
	SIRP γ protein is a possible immunoglobulin-like cell surface receptor that mediates cell-cell adhesion by binding to CD47. This interaction enhances antigen-specific T cell proliferation and provides costimulatory signals for T cell activation, highlighting the role of SIRP gamma in regulating immune responses. SIRP gamma Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SIRP gamma protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P72190

	FANCC Protein, Human (His-SUMO) Ba80I15.1; FA3; FAC; FACC; FANCC; FANCC_HUMAN; Fanconi anemia complementation group C; Fanconi anemia complementation group C protein; Fanconi anemia group C protein; Fanconi pancytopenia type 3; FLJ14675; Protein FACC	Human	E. coli
	FANCC Protein repairs and maintains DNA, aids in STAT1 activation, and forms a multisubunit FA complex. It interacts with ZBTB32, STAT1, CDK1, and EIF2AK2. The FA complex excludes FA patients and may include HSP70, while interaction with EIF2AK2 leads to increased activation and cell death. FANCC Protein, Human (His-SUMO) is the recombinant human-derived FANCC protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of FANCC Protein, Human (His-SUMO) is 558 a.a., with molecular weight of ~79.4 kDa.

HY-P78505

	PD-L2 Protein, Human (HEK293, His-Avi) PDL2; PD-L2; Butyrophilin B7-DC; CD273, PDCD1 ligand 2; PDCD1L2; PDCD1LG2; B7DC; Ba574F11.2; Btdc	Human	HEK293
	PD-L2 Protein, operating independently of PDCD1, plays a vital role in T-cell proliferation and IFNG production. Its interaction with PDCD1 inhibits proliferation and cytokine production. The interplay between PD-L2 and PDCD1 regulates immune responses, influencing T-cell activation and function. This molecular interaction adds complexity to mechanisms governing T-cell behavior, highlighting PD-L2's versatile role in immune regulation. PD-L2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived PD-L2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of PD-L2 Protein, Human (HEK293, His-Avi) is 201 a.a., with molecular weight of 40-52 kDa.

HY-P700894

PD-L2 Protein, Cynomolgus (HEK293, C-His)

PDL2; PD-L2; Butyrophilin B7-DC; CD273, PDCD1 ligand 2; PDCD1L2; PDCD1LG2; B7DC; Ba574F11.2; Btdc
Cynomolgus HEK293

HY-P79293

	IL-1RA/IL-1F3 Protein, Porcine Interleukin-1 receptor antagonist protein; IL1RN; IL-1RN; IL-1ra; IRAP; IL1 inhibitor; IRAP1; Interleukin 1 Receptor Antagonist	Porcine	E. coli
	The IL-1RA/IL-1F3 protein, a robust anti-inflammatory antagonist in the interleukin-1 family, specifically targets proinflammatory cytokines IL1B and IL1A. Countering IL1's inflammatory effects, this protein crucially protects against immune dysregulation and prevents uncontrolled systemic inflammation triggered by various innate stimulatory agents, including pathogens. Serving as a regulatory shield against IL1-mediated responses, IL-1RA/IL-1F3 significantly contributes to maintaining immune balance and curtailing excessive inflammatory reactions. IL-1RA/IL-1F3 Protein, Porcine is the recombinant Porcine-derived IL-1RA/IL-1F3 protein, expressed by E. coli, with tag free. The total length of IL-1RA/IL-1F3 Protein, Porcine is 152 a.a., with molecular weight of ~17.55 kDa.

HY-P71684

	BCAP31 Protein, Human (GST) 6C6 AG; 6C6 AG tumor associated antigen; B-cell receptor-associated protein 31; Ba31; CDM; CDM protein; DXS1357E; MS950; p28; p28 Bap31; Protein CDM; RP23-329M9.5	Human	E. coli
	The BCAP31 protein acts as a chaperone and is one of the most abundant endoplasmic reticulum (ER) proteins. The BCAP31 protein also serves as a cargo receptor for transmembrane protein export. BCAP31 stimulates the translocation of NDUFS4 and NDUFB11 to mitochondria, interacts with BCL2, and may be involved in caspase-8-mediated apoptosis. BCAP31 Protein, Human (GST) is the recombinant human-derived BCAP31 protein, expressed by E. coli , with N-GST labeled tag. The total length of BCAP31 Protein, Human (GST) is 242 a.a., with molecular weight of ~54.5 kDa.

HY-P72209

	GOLM1 Protein, Human (His) Ba379P1.3; C9orf155; Chromosome 9 open reading frame 155; Golgi membrane protein 1; Golgi membrane protein GP73; Golgi phosphoprotein 2; Golgi protein 73 kD ; Golgi protein 73kD ; GOLM 1; GOLM1; GOLM1_HUMAN; GOLPH 2; GOLPH2; GP 73; GP73; PSEC0257	Human	E. coli
	GOLM1 Protein, amid partial comprehension, acts as a cellular response protein to viral infections, with an intricate role yet to be fully understood. Interactions with DYM suggest potential links to cellular dynamics or host-virus interactions. Further investigation is crucial to delineate GOLM1's specific contributions and implications in cellular defense mechanisms against viral infections. GOLM1 Protein, Human (His) is the recombinant human-derived GOLM1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72209A

	GOLM1 Protein, Human (His, Solution) Ba379P1.3; C9orf155; Chromosome 9 open reading frame 155; Golgi membrane protein 1; Golgi membrane protein GP73; Golgi phosphoprotein 2; Golgi protein 73 kD ; Golgi protein 73kD ; GOLM 1; GOLM1; GOLM1_HUMAN; GOLPH 2; GOLPH2; GP 73; GP73; PSEC0257	Human	E. coli
	GOLM1 Protein, amid partial comprehension, acts as a cellular response protein to viral infections, with an intricate role yet to be fully understood. Interactions with DYM suggest potential links to cellular dynamics or host-virus interactions. Further investigation is crucial to delineate GOLM1's specific contributions and implications in cellular defense mechanisms against viral infections. GOLM1 Protein, Human (His, Solution) is the recombinant human-derived GOLM1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702699

	CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His) CDC2L6; CDK19; cyclin dependent kinase 19; CDK11; CDC2L6; Ba346C16.3; cyclin-dependent kinase 19; CDC2-related protein kinase 6; CDK8-like cyclin-dependent kinase; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6; cell division protein kinase 19; cyclin dependent kinase 19 variant 2; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; death-preventing kinase; EC 2.7.11.22	Human	Sf9 insect cells

Cat. No.	Product Name	Chemical Structure

HY-15306S

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells ^[3] .}

HY-10997S

Ibrutinib-d5

Ibrutinib-d₅ is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor[1].

HY-153951S

BTK-IN-26
BTK-IN-26 (compound 18) is a potent inhibitor of Bruton's tyrosine kinase (BTK) and its C481 mutant, with IC₅₀ values of 0.7 and 0.8 nM for *BTK* and **BTK C481S*, respectively. BTK*-IN-26 can be used for cancer and autoimmune diseases research .

HY-126432S

(Rac)-BA-1049-d5

(Rac)-BA-1049-d₅ is deuterated labeled (Rac)-BA-1049.
HY-160219S

BTK-IN-33

BTK-IN-33 is a Btk inhibitor with anticancer effects (WO2023174300A1; compound I) .

HY-N0733S2

Glucosamine-13C,15N hydrochloride
Glucosamine- ¹³C, ¹⁵N (hydrochloride) is the ¹³C and ¹⁵N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, i

HY-B0271S1

Pyrazinamide-13C,15N
Pyrazinamide- ¹³C, ¹⁵N is ¹⁵N and ¹³C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-N0650S6

L-Serine1-13C,15N
L-Serine1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-Y0418S

Dulcite-13C

Dulcite- ¹³C is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].

HY-B0389S10

D-Glucose-13C
D-Glucose- ¹³C is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-B0389S29

D-Glucose-18O
D-Glucose- ¹⁸O is the ¹⁸O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules

HY-13613S2

Dutasteride-13C,15N,d
Dutasteride- ¹³C, ¹⁵N,d is ¹⁵N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .

HY-13458S1

Droxidopa-13C2,15N hydrochloride
Droxidopa- ¹³C₂, ¹⁵N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].

HY-66005S4

Acetaminophen-13C2,15N
Acetaminophen- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].

HY-15236S1

PSI-6206-d1,13C,15N2
PSI-6206-d1, ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC₉₀ of >100 μM.

HY-N1480S

(-)-Fucose-13C
(-)-Fucose- ¹³C is the ¹³C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[1]

HY-Y1250S6

Fmoc-Gly-OH-13C2,15N
Fmoc-Gly-OH- ¹³C₂, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.

HY-Z0283S

Benzamide-15N

Benzamide- ¹⁵N is a ¹⁵N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP)[1][2].

HY-125818S2

Cytidine-5'-triphosphate-13C,d1 dilithium

Cytidine-5'-triphosphate- ¹³C,d₁ (Cytidine triphosphate- ¹³C,d₁ dilithium; 5'-CTP- ¹³C,d₁) dilithium is deuterium and ¹³C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

HY-W067028S

Semicarbazide-13C,15N2 hydrochloride

Semicarbazide- ¹³C, ¹⁵N₂ hydrochloride is ¹⁵N and ¹³C labeled Semicarbazide.

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-Y0504S2

Trimethylammonium chloride-15N

Trimethylammonium chloride- ¹⁵N is the ¹⁵N labeled Trimethylammonium chloride[1]. Trimethylammonium chloride is an endogenous metabolite.

HY-A0070AS1

Liothyronine-13C9,15N
Liothyronine- ¹³C₉, ¹⁵N is the ¹³C and ¹⁵N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].

HY-B0150S1

Nicotinamide-15N,13C3
Nicotinamide- ¹⁵N, ¹³C₃ is the ¹³C-labeled and ¹⁵N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-N0733S5

Glucosamine-13C6,15N hydrochloride
Glucosamine- ¹³C₆, ¹⁵N (hydrochloride) is the ¹³C and ¹⁵N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids,

HY-13417S

AICAR-13C2,15N
AICAR- ¹³C₂, ¹⁵N (Acadesine- ¹³C₂, ¹⁵N; AICA Riboside- ¹³C₂, ¹⁵N)is the ¹³C and ¹⁵N labeledAICAR(HY-13417) . AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor ^[3].

HY-Y0842S

Formamide-13C

Formamide- ¹³C is the ¹³C-labeled Formamide. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.

HY-101037S

Sarcosine-15N
Sarcosine- ¹⁵N is the ¹⁵N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

HY-N0623S1

L-Tryptophan-13C

L-Tryptophan- ¹³C is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
HY-N0623S7

L-Tryptophan-15N

L-Tryptophan- ¹⁵N is the ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
HY-N0378S1

D-Mannitol-13C

D-Mannitol- ¹³C is the ¹³C labeled D-Mannitol[1][2][3][4].

HY-N0733S

Glucosamine-13C hydrochloride
Glucosamine- ¹³C (hydrochloride) is the ¹³C labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a

HY-N1150S2

Thymidine-13C
Thymidine- ¹³C is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]

HY-N0733S4

Glucosamine-15N hydrochloride
Glucosamine- ¹⁵N (hydrochloride) is the ¹⁵N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a

HY-N0667S4

L-Asparagine-4-13C monohydrate
L-Asparagine-4- ¹³C (monohydrate) is the ¹³C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-Y0418S1

Dulcite-13C-1

Dulcite- ¹³C-1 is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
HY-Y0418S2

Dulcite-13C-2

Dulcite- ¹³C-2 is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
HY-Y0418S3

Dulcite-13C-3

Dulcite- ¹³C-3 is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-B0617S1

S-Adenosyl-L-methionine-13C

S-Adenosyl-L-methionine- ¹³C is the ¹³C labeled S-Adenosyl-L-methionine[1]. S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[2][3][4].

HY-B0178AS

Guanidine-13C,15N3 hydrochloride
Guanidine- ¹³C, ¹⁵N₃ (hydrochloride)is the ¹³C-labeled and ¹⁵N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].

HY-N0650S5

L-Serine-13C3,15N
L-Serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-13677S1

6-Mercaptopurine-13C2,15N
6-Mercaptopurine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-N0091S1

Hypoxanthine-13C,15N2
Hypoxanthine- ¹³C, ¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Furaltadone. Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci

HY-N0091S3

Hypoxanthine-13C2,15N

Hypoxanthine- ¹³C₂, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled DL-Cystine[1].

HY-13623S1

Entecavir-13C2,15N
Entecavir- ¹³C₂, ¹⁵N (BMS200475- ¹³C₂, ¹⁵N; SQ34676- ¹³C₂, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

HY-14164S1

Zileuton-13C2,15N

Zileuton- ¹³C₂, ¹⁵N is ¹⁵N and ¹³C labeled Zileuton (HY-14164). Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
HY-N0545S

Taurocholic acid-13C2,15N sodium

Taurocholic acid- ¹³C₂, ¹⁵N (sodium) is the ¹³C- and ¹⁵N- labeled Taurocholic acid (sodium).

HY-14291S2

Vildagliptin-13C5,15N
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-B0389S11

D-Glucose-13C-1
D-Glucose- ¹³C-1 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82726

Tissue Factor Antibody (YA2471)

F3; Tissue factor; TF; Coagulation factor III; Thromboplastin; CD antigen CD142
WB, IHC-P Human, Mouse, Rat

HY-P80576

	BTK Antibody (YA816) BTK; AGMX1; ATK; BPK; Tyrosine-protein kinase BTK; Agammaglobulinaemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase	WB, IP	Human
	BTK Antibody (YA816) is a non-conjugated and Mouse origined monoclonal antibody about 76 kDa, targeting to BTK (5B12). It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80454

	*Phospho-BTK(Y223) Antibody* BTK(Y223); BTK (phospho Y223); p-BTK (phospho Y223); Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton’s Tyrosine Kinase; BTK; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP00000063593; PSCTK 1; PSCTK1; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; XLA.	WB, IHC-P, IHC-F, ICC/IF	Human
	Phospho-BTK(Y223) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 76 kDa, targeting to Phospho-BTK(Y223). It can be used for WB, IHC-P, IHC-F, ICC, IF assays with tag free, in the background of Human.

HY-P81667

SNAP25 Antibody (YA1412)

Synaptosomal-associated protein 25; SNAP-25; super protein; sup; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP
WB, ICC/IF, IP Human, Mouse, Rat
HY-P82258

SMYD3 Antibody (YA2003)

KMT3E; ZMYND1; ZNFN3A1; Ba74P14.1
WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P83559

NDUFAF5 Antibody (YA3304)

C20orf7; dJ842G6.1; Ba526K24.2
WB, IHC-P, IP Human, Mouse
HY-P83557

NDUFAF4 Antibody (YA3302)

My013; C6orf66; HRPAP20; HSPC125; Ba22L21.1
WB, ICC/IF, IP Human
HY-P83211

TAF1 Antibody (YA2956)

Ba2R; CCG1; CCGS; DYT3; N TAF1; NSCL2; p250; TAF1; TAF2A; TAFII250; XDP
WB Human, Mouse, Rat

HY-P83655

	NUFIP1 Antibody Ba540M5.1; Nuclear FMRP interacting protein 1; Nuclear fragile X mental retardation interacting protein 1; nuclear fragile X mental retardation protein interacting protein 1; NUFIP.	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat

HY-P83350

	IL-1 Receptor Antagonist Protein Antibody (YA3095) IL-1 Receptor Antagonist Protein; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse

HY-P83523

	General Transcription Factor II I Antibody (YA3268) GTF2I; BaP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BaP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region	WB, IHC-F, IHC-P, ICC/IF	Human

HY-P80706

	Histone H2B Antibody (YA737) H2BK5ac; H2B 1A; H2B; H2B histone family; H2B2f; H2Ba; H2Bf; HIST2H2BF; histone H2B; histone H2B type 1; Histone H2B type 2-F	WB, IHC-P	Human, Mouse, Rat
	Histone H2B Antibody (YA737) is a non-conjugated and Mouse origined monoclonal antibody about 14 kDa, targeting to Histone H2B (7E2). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80176

	Histone H3 (tri methyl K9) Antibody H3K9me3; H3 histone family member E pseudogene; H3 histone family, memberA; H3/A; H31_HUMAN; H3F3; H3FA; Hist1h3a; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; histone 1, H3a; Histone cluster 1, H3a; Histone H3 3 pseudogene; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; HistoneH3/l; H3K9me2; HistoneH3(trimethylK9)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Histone H3 (tri methyl K9) Antibody is a non-conjugated and Mouse origined monoclonal antibody about 15 kDa, targeting to Histone H3 (tri methyl K9). It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

Cat. No.	Product Name		Classification

HY-D1327

Cyanine3 azide chloride		Azide Labeling and Fluorescence Imaging
Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λ_ex=684 nm, λ_em=710 nm) ^{[1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.}

HY-156497

Biotin-PEG8-Me-Tet

Labeling and Fluorescence Imaging Tetrazine

Biotin-PEG8-Me-Tet is a biotin labeling.

HY-50896S1

Erlotinib-13C6 CP-358774-<sup>13sup>C₆; NSC 718781-<sup>13sup>C₆; OSI-774-<sup>13sup>C₆		Alkynes
Erlotinib- ¹³C₆ is a ¹³C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

HY-12008S1

Erlotinib-13C6 hydrochloride CP-358774-<sup>13sup>C₆ hydrochloride; NSC 718781-<sup>13sup>C₆ hydrochloride; OSI-774-<sup>13sup>C₆ hydrochloride		Alkynes
Erlotinib- ¹³C₆ (hydrochloride) is the ¹³C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-<sup>13sup>C,d₃; AZT-<sup>13sup>C,d₃; ZDV-<sup>13sup>C,d₃		Azide
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-B0216S2

Ethynyl Estradiol-13C2 17α-Ethynylestradiol-<sup>13sup>C₂; Ethynylestradiol-<sup>13sup>C₂		Alkynes
Ethynyl Estradiol- ¹³C₂ is the ¹³C-labeled Ethynyl Estradiol. Ethynyl Estradiol-13C2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605BS

Rasagiline-13C3 mesylate racemic AGN1135-<sup>13sup>C₃; TVP1012-<sup>13sup>C₃ racemic		Alkynes
Rasagiline- ¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130481

Propargyl-PEG4-acid		PROTAC Synthesis Alkynes
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC₅₀ of 200 nM in THP-1 cells . Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130504

Propargyl-PEG1-acid 1 Publications Verification		Alkynes PROTAC Synthesis
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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