Search Result

Pathways Recommended:	Apoptosis Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

induce tumor cell apoptosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (247) TNF Receptor (2) 5 alpha Reductase (1) ADC Cytotoxin (4) Akt (6) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (8) Antibody-Drug Conjugates (ADCs) (1) Aryl Hydrocarbon Receptor (1) ASCT (2) ATM/ATR (1) Aurora Kinase (1) Autophagy (31) Bacterial (13) Bcl-2 Family (10) Bcr-Abl (1) c-Fms (3) c-Kit (3) c-Met/HGFR (8) c-Myc (5) Caspase (5) CDK (12) Chloride Channel (2) Complement System (1) COX (4) CRISPR/Cas9 (1) CXCR (2) Deubiquitinase (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (12) Drug Metabolite (1) DYRK (1) E1/E2/E3 Enzyme (3) EGFR (7) Endogenous Metabolite (9) Ephrin Receptor (1) ERK (3) Eukaryotic Initiation Factor (eIF) (1) FAK (2) Fatty Acid Synthase (FASN) (3) FGFR (1) FKBP (3) FLT3 (3) Fungal (2) FXR (1) GABA Receptor (2) Galectin (1) Gli (1) Glucosidase (1) GLUT (1) Glutaminase (2) Glutathione S-transferase (1) GSK-3 (1) HDAC (14) Hedgehog (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) HIV (2) HSP (6) HSV (2) IAP (1) IGF-1R (1) Insulin Receptor (1) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (1) JAK (2) JNK (2) KLF (1) Lactate Dehydrogenase (1) LXR (1) MDM-2/p53 (10) MELK (1) METTL3 (1) MicroRNA (1) Microtubule/Tubulin (20) Mitochondrial Metabolism (5) MMP (3) Mps1 (1) mTOR (8) Necroptosis (3) NF-κB (6) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (2) Oct3/4 (1) Organoid (1) Orthopoxvirus (2) P-glycoprotein (2) Parasite (9) PARP (4) PDHK (1) PDK-1 (1) PERK (1) Phosphatase (2) PI3K (8) Pim (1) PKA (2) PKC (2) PKD (1) Polo-like Kinase (PLK) (1) Progesterone Receptor (1) PROTACs (2) Proteasome (1) Proton Pump (1) PTEN (3) Pyroptosis (1) Raf (1) Ras (2) Reactive Oxygen Species (14) RIP kinase (1) ROS Kinase (5) RSV (1) Ser/Thr Protease (1) SF3B1 (1) Smo (3) SphK (1) Src (1) STAT (6) Survivin (1) Thymidylate Synthase (2) Toll-like Receptor (TLR) (2) Topoisomerase (10) Trk Receptor (1) TrxR (1) VD/VDR (2) VEGFR (1) Wnt (1) YAP (1) β-catenin (2)
By Research Areas:	Cancer (289) Cardiovascular Disease (5) Endocrinology (1) Infection (23) Inflammation/Immunology (29) Metabolic Disease (8) Neurological Disease (12)

By Targets:

Apoptosis (247)

TNF Receptor (2)

5 alpha Reductase (1)

ADC Cytotoxin (4)

Akt (6)

Anaplastic lymphoma kinase (ALK) (2)

Androgen Receptor (3)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (8)

Antibody-Drug Conjugates (ADCs) (1)

Aryl Hydrocarbon Receptor (1)

ASCT (2)

ATM/ATR (1)

Aurora Kinase (1)

Autophagy (31)

Bacterial (13)

Bcl-2 Family (10)

Bcr-Abl (1)

c-Fms (3)

c-Kit (3)

c-Met/HGFR (8)

c-Myc (5)

Caspase (5)

CDK (12)

Chloride Channel (2)

Complement System (1)

COX (4)

CRISPR/Cas9 (1)

CXCR (2)

Deubiquitinase (2)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (12)

Drug Metabolite (1)

DYRK (1)

E1/E2/E3 Enzyme (3)

EGFR (7)

Endogenous Metabolite (9)

Ephrin Receptor (1)

ERK (3)

Eukaryotic Initiation Factor (eIF) (1)

FAK (2)

Fatty Acid Synthase (FASN) (3)

FGFR (1)

FKBP (3)

FLT3 (3)

Fungal (2)

FXR (1)

GABA Receptor (2)

Galectin (1)

Gli (1)

Glucosidase (1)

GLUT (1)

Glutaminase (2)

Glutathione S-transferase (1)

GSK-3 (1)

HDAC (14)

Hedgehog (3)

Hexokinase (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Demethylase (1)

HIV (2)

HSP (6)

HSV (2)

IAP (1)

IGF-1R (1)

Insulin Receptor (1)

Integrin (1)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

JAK (2)

JNK (2)

KLF (1)

Lactate Dehydrogenase (1)

LXR (1)

MDM-2/p53 (10)

MELK (1)

METTL3 (1)

MicroRNA (1)

Microtubule/Tubulin (20)

Mitochondrial Metabolism (5)

MMP (3)

Mps1 (1)

mTOR (8)

Necroptosis (3)

NF-κB (6)

Nuclear Hormone Receptor 4A/NR4A (1)

Nucleoside Antimetabolite/Analog (2)

Oct3/4 (1)

Organoid (1)

Orthopoxvirus (2)

P-glycoprotein (2)

Parasite (9)

PARP (4)

PDHK (1)

PDK-1 (1)

PERK (1)

Phosphatase (2)

PI3K (8)

Pim (1)

PKA (2)

PKC (2)

PKD (1)

Polo-like Kinase (PLK) (1)

Progesterone Receptor (1)

PROTACs (2)

Proteasome (1)

Proton Pump (1)

PTEN (3)

Pyroptosis (1)

Raf (1)

Ras (2)

Reactive Oxygen Species (14)

RIP kinase (1)

ROS Kinase (5)

RSV (1)

Ser/Thr Protease (1)

SF3B1 (1)

Smo (3)

SphK (1)

Src (1)

STAT (6)

Survivin (1)

Thymidylate Synthase (2)

Toll-like Receptor (TLR) (2)

Topoisomerase (10)

Trk Receptor (1)

TrxR (1)

VD/VDR (2)

VEGFR (1)

Wnt (1)

YAP (1)

β-catenin (2)

By Research Areas:

Cancer (289)

Cardiovascular Disease (5)

Endocrinology (1)

Infection (23)

Inflammation/Immunology (29)

Metabolic Disease (8)

Neurological Disease (12)

297

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Apoptosis TNF Receptor BRK Itk TOPK SNIPERs NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126856

HC-Toxin

HDAC Apoptosis Cancer

HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell apoptosis and has anticancer effects .
HY-N7000

Perillyl alcohol

Apoptosis Endogenous Metabolite Cancer

Perillyl alcohol, a monoterpene, is active in inducing apoptosis in tumor cells without affecting normal cells .
HY-N8207

Gypenoside LI

Apoptosis MicroRNA Cancer

Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .
HY-122760

Bax activator-1

Bcl-2 Family Apoptosis Cancer

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis .

HC-Toxin	HDAC Apoptosis	Cancer
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell *apoptosis* and has anticancer effects .

Perillyl alcohol	Apoptosis Endogenous Metabolite	Cancer
Perillyl alcohol, a monoterpene, is active in inducing *apoptosis* in tumor cells without affecting normal cells .

Gypenoside LI	Apoptosis MicroRNA	Cancer
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

Bax activator-1	Bcl-2 Family Apoptosis	Cancer
Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis .

HY-129715

MPI-0441138	Apoptosis	Cancer
MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death .

HY-135217

Apiole	Apoptosis	Cancer
Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-N10520

Pectic acid Methyl protopectin; Polygalacturonic acid	Apoptosis Necroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell *apoptosis* and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease .

HY-N0797

(20S)-Protopanaxadiol 20-Epiprotopanaxadiol; 20(S)-APPD	P-glycoprotein Reactive Oxygen Species Apoptosis	Cancer
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-P99934

Eftozanermin alfa ABBV-621	Apoptosis	Cancer
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces *apoptosis* in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

HY-145729

Danvatirsen AZD9150	STAT Apoptosis	Cancer
Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-145729A

Danvatirsen sodium AZD9150 sodium	Apoptosis STAT	Cancer
Danvatirsen sodium is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen sodium binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-N7223

Lappaol F	YAP Apoptosis	Cancer
Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP<、b> mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell *apoptosis, and inhibits tumor* growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) .

HY-14808

Adarotene 5+ Cited Publications ST1926	Apoptosis	Cancer
Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.

HY-120429

SKLB-163	Apoptosis	Cancer
SKLB-163 is an orally active inhibitor for Rho GDP-dissociation (RhoGDI). SKLB-163 inhibits highly expressed RhoGDI tumor cell proliferation and migration, and increases radiosensitivity of tumor cells. SKLB-163 induces cancer cell *Apoptosis* .

HY-N11638

Ganoderic acid R	Apoptosis	Cancer
Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing *apoptosis* on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1) .

HY-N2632

Uvarigrin

Apoptosis Cancer

Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

Uvarigrin	Apoptosis	Cancer
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

HY-114440

Belapectin GR-MD-02	Galectin Apoptosis	Cancer
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell *Apoptosis. Belapectin promotes tumor* regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity K_i of 2.8 μM .

HY-121410

Narasin	Bacterial Apoptosis Parasite NF-κB Antibiotic	Infection Cancer
Narasin is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells *apoptosis*. Narasin has antimicrobial and anticancer activity .

HY-N3055

Pinusolide	Apoptosis	Cancer
Pinusolide is a known platelet-activating factor (PAF) receptor binding antagonist. Pinusolide not only decreases the proliferation activity of tumor cells but specifically induces *apoptosis* .

HY-151620

Antitumor agent-80

Apoptosis Cancer

Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells .

Antitumor agent-80	Apoptosis	Cancer
Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces *apoptosis* in tumor cells .

HY-112225

Narasin sodium	Antibiotic Bacterial Parasite NF-κB Apoptosis	Infection Cancer
Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells *apoptosis*. Narasin sodium has antimicrobial and anticancer activity .

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Apoptosis	Cancer
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells *apoptosis*. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

HY-N0706

Gracillin 1 Publications Verification	Apoptosis Autophagy	Cancer
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-N6601

Pomolic acid Randialic acid A	Apoptosis	Cancer
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell *apoptosis*. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-111838

ZZW-115

Apoptosis Cancer

ZZW-115 is a potent NUPR1 inhibitor, with a K_d of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and apoptosis. Anticancer activity .

ZZW-115	Apoptosis	Cancer
ZZW-115 is a potent NUPR1 inhibitor, with a K_d of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and *apoptosis*. Anticancer activity .

HY-111838A

ZZW-115 hydrochloride 1 Publications Verification	Apoptosis	Cancer
ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a K_d of 2.1 μM. ZZW-115 hydrochloride induces tumor cell death by necroptosis and *apoptosis*. Anticancer activity .

HY-N0114A

(±)-Evodiamine	Topoisomerase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
(±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their *apoptosis* .

HY-14429

(-)-Irofulven MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863	DNA Alkylator/Crosslinker Apoptosis	Cancer
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells *apoptosis*, and has potent antitumor activity .

HY-N2198

Podocarpusflavone A	Topoisomerase Apoptosis	Cancer
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-W013032A

Oxamic acid sodium 3 Publications Verification Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce *apoptosis* .

HY-13566

Belotecan CKD-602 free base	Topoisomerase Apoptosis	Cancer
Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer .

HY-11005

BX-912 4 Publications Verification	PDK-1 Apoptosis	Cancer
BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC₅₀=26 nM). BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces *apoptosis* .

HY-10222

Ixabepilone 4 Publications Verification BMS-247550; Aza-epothilone B	Microtubule/Tubulin Apoptosis Bacterial	Cancer
Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.

HY-N0211

Cyasterone	EGFR Apoptosis	Cancer
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced *apoptosis* and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-123697

VE-465

Aurora Kinase Cancer

VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models .

VE-465	Aurora Kinase	Cancer
VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell *apoptosis. VE-465 has anticancer effects in multiple tumor* models .

HY-146048

Antitumor agent-57	Apoptosis Reactive Oxygen Species	Cancer
Antitumor agent-57 (Compound 3o) is an NQO1-directed antitumor agent. Antitumor agent-57 inhibits tumor cell growth, triggers ROS generation and induces cell *apoptosis* .

HY-126412

Neochamaejasmine A	Apoptosis	Cancer
Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and *apoptosis* in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer .

HY-149672

ABBV-467	Bcl-2 Family	Cancer
ABBV-467 is a selective MCL-1 inhibitor (K_i: <0.01 nM). ABBV-467 induces *apoptosis. ABBV-467 induces* cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma .

HY-P99655

Ifabotuzumab KB004	Ephrin Receptor Apoptosis	Cancer
Ifabotuzumab (KB004) is an IgG1κ antibody targeting EphA3 (K_D=610 pM). Ifabotuzumab induces tumor cell apoptosis, activates Antibody-dependent cell mediated cytotoxicity (ADCC), and damages tumor vasculature. Ifabotuzumab reduces human idiopathic pulmonary fibrosis (IPF) CCR10 ⁺ cells and improves pulmonary fibrosis .

HY-163076

Anticancer agent 174	Others	Others
Anticancer agent 174 (BA-3) is an anticancer agent. Anticancer agent 174 induces tumor cell *apoptosis* through the mitochondrial pathway. Anticancer agent 174 inhibits cancer cell proliferation in melanoma mouse xenograft model .

HY-13547

ADPM06	Apoptosis	Cancer
ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC₅₀ values in the micro-molar range in human tumor cells and induces *apoptosis* .

HY-149631

HFY-4A	HDAC	Cancer
HFY-4A is a HDAC inhibitor. HFY-4A inhibits breast cancer cell proliferation, migration, and invasion, and induces cell *apoptosis. HFY-4A induces* immunogenic cell death (ICD). HFY-4A inhibits tumor growth in breast cancer xenograft mouse models .

HY-130117

AlbA-DCA	Reactive Oxygen Species Apoptosis	Cancer
AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A (AlbA) to a dichloroacetate acid (DCA) subunit. AlbA-DCA can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in tumor microenvironment (TME), and also selectively kills cancer cells and induce *apoptosis* .

HY-P99270

Tigatuzumab CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody	Apoptosis	Cancer
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell *apoptosis* of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .

HY-161412

STR-V-53	HDAC	Cancer
STR-V-53 is an HDAC inhibitor (IC50 in nM).STR-V-53 increases histone acetylation in tumor cells by inhibiting the activity of these enzymes, which in turn regulates gene expression.STR-V-53 inhibits tumor growth, and induces *apoptosis* .

HY-121250

Fasnall	Fatty Acid Synthase (FASN) Apoptosis	Cancer
Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC₅₀ of 3.71 μM. Fasnall induces *apoptosis* in HER2 ⁺ breast cancer cell lines. Fasnall shows potent anti-tumor activities .

HY-155069

Antiproliferative agent-27	Apoptosis	Cancer
Antiproliferative agent-27 (compound 11) is an antiproliferative agent that significantly reduces the number of tumor cell colonies and induces *apoptosis*. Antiproliferative agent-27 has the potential to be used in the study of cancer .

HY-N12141

Flaccidoside II	Apoptosis	Inflammation/Immunology
Flaccidoside II inhibits proliferation and induces *apoptosis* in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-149410

MSN8C	Others	Cancer
MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell *apoptosis. MSN8C shows significant anti-tumor* cell proliferation activity in vitro .

HY-19992

3-Bromopyruvic acid 15+ Cited Publications Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

Cat. No.	Product Name

HY-L135

Cancer Stem Cells Compound Library

2,138 compounds

With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on.

Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment.

MCE supplies a unique collection of 2,138 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

HY-L133

Cuproptosis Compound Library

188 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 188 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P99934

Eftozanermin alfa ABBV-621	Apoptosis	Cancer
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces *apoptosis* in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

HY-P99655

Ifabotuzumab KB004	Ephrin Receptor Apoptosis	Cancer
Ifabotuzumab (KB004) is an IgG1κ antibody targeting EphA3 (K_D=610 pM). Ifabotuzumab induces tumor cell apoptosis, activates Antibody-dependent cell mediated cytotoxicity (ADCC), and damages tumor vasculature. Ifabotuzumab reduces human idiopathic pulmonary fibrosis (IPF) CCR10 ⁺ cells and improves pulmonary fibrosis .

HY-P99270

Tigatuzumab CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody	Apoptosis	Cancer
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell *apoptosis* of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of *TNF-like weak inducer* of apoptosis (TWEAK)*. TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces* tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P99275

Patritumab 1 Publications Verification Human Anti-ERBB3 Recombinant Antibody	EGFR Akt ERK PARP Survivin	Cancer
Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell *apoptosis* and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .

HY-P99413

IMAB027 ASP1650	Inhibitory Antibodies	Cancer
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 ⁺ ovarian and testicular cancer cell lines .

HY-P99956

Zilovertamab vedotin VLS-101; MK-2140	Antibody-Drug Conjugates (ADCs) Apoptosis	Cancer
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces *apoptosis*. Zilovertamab vedotin can be used in research of cancer .

HY-P99284

Dalotuzumab MK-0646; h7C10	IGF-1R Apoptosis	Cancer
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces *apoptosis* and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7000

Perillyl alcohol	Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Perillyl alcohol, a monoterpene, is active in inducing *apoptosis* in tumor cells without affecting normal cells .

HY-N8207

Gypenoside LI	Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer	Apoptosis MicroRNA
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

HY-N0797

(20S)-Protopanaxadiol 20-Epiprotopanaxadiol; 20(S)-APPD	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	P-glycoprotein Reactive Oxygen Species Apoptosis
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-135217

Apiole	Structural Classification Natural Products Source classification Mikania cordifolia (L.f.) Willd. Plants Umbelliferae	Apoptosis
Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-N10520

Pectic acid Methyl protopectin; Polygalacturonic acid	Structural Classification Natural Products Classification of Application Fields Source classification Rutaceae Plants Endogenous metabolite Citrus reticulata Blanco Human Gut Microbiota Metabolites Polysaccharides Microorganisms Inflammation/Immunology Disease Research Fields Saccharides Cancer	Apoptosis Necroptosis Endogenous Metabolite
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell *apoptosis* and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease .

HY-N7223

Lappaol F	Structural Classification Source classification Lignans Phenylpropanoids Plants Compositae Gueldenstaedtia verna (Georgi) Boriss.	YAP Apoptosis
Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP<、b> mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell *apoptosis, and inhibits tumor* growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) .

HY-N11638

Ganoderic acid R	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis
Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing *apoptosis* on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1) .

HY-N2632

Uvarigrin	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Apoptosis
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

HY-N3055

Pinusolide	Cupressaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer Calocedrus decurrens (Torr.) Florin	Apoptosis
Pinusolide is a known platelet-activating factor (PAF) receptor binding antagonist. Pinusolide not only decreases the proliferation activity of tumor cells but specifically induces *apoptosis* .

HY-112225

Narasin sodium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Polyether Antibiotics Cancer	Antibiotic Bacterial Parasite NF-κB Apoptosis
Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells *apoptosis*. Narasin sodium has antimicrobial and anticancer activity .

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Quinones Classification of Application Fields Source classification Benzene Quinones Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells *apoptosis*. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

HY-N0706

Gracillin 1 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Autophagy
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-N6601

Pomolic acid Randialic acid A	Triterpenes Euscaphis japonica other families Classification of Application Fields Staphyleaceae Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell *apoptosis*. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-N0114A

(±)-Evodiamine	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids	Topoisomerase Apoptosis
(±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their *apoptosis* .

HY-N2198

Podocarpusflavone A	Structural Classification Flavonoids Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Plants Garcinia subelliptica Biflavones Disease Research Fields Cancer	Topoisomerase Apoptosis
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-N0211

Cyasterone	Classification of Application Fields Labiatae Source classification Amaranthaceae Plants Laggera crispata (Vahl) Hepper & J. R. I. Wood Disease Research Fields Achyranthes bidentata Steroids Cancer	EGFR Apoptosis
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced *apoptosis* and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-126412

Neochamaejasmine A	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis
Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and *apoptosis* in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer .

HY-N12141

Flaccidoside II	Structural Classification Polysaccharides Anemone flaccida Fr. Schmidt Source classification Ranunculaceae Plants Saccharides	Apoptosis
Flaccidoside II inhibits proliferation and induces *apoptosis* in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-N7496

Odoroside A	Apocynaceae Structural Classification Natural Products Classification of Application Fields Nerium oleander Plants Disease Research Fields Cancer	Apoptosis
Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death .

HY-129337

Reveromycin A	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Antibiotic Fungal Apoptosis
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing *apoptosis* specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity .

HY-N10447

Kurzipene D	Terpenoids Source classification Casearia kurzii C. B. Clarke Diterpenoids Plants Salicaceae	Apoptosis
Kurzipene D (compound 4) is a potent anticancer agent. Kurzipene D induces the *apoptosis* and arrested the HepG2 cell cycle at S stage. Kurzipene D shows anti-tumor effects using in vivo zebrafish model. Kurzipene D has the property of inhibiting tumor proliferation and migration .

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-N3442

Juglanin 5 Publications Verification	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	JNK Apoptosis Autophagy
Juglanin, a occurring flavonoid that can be isolated from crude Polygonum aviculare, is a JNK acticator, with anti-inflammatory, anti-oxidant and anti-tumor activities. Juglanin can induce *apoptosis* and autophagy on human breast cancer cells .

HY-N5058

Dehydroeffusol	Natural Products Juncus effusus Linn. Classification of Application Fields Juncaceae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate *apoptosis*. It shows very low toxicity .

HY-N5106

(E)-Flavokawain A	Flavonoids Chalcones Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice .

HY-B1610

Sodium citrate dihydrate 3 Publications Verification Trisodium citrate dihydrate; Citric acid trisodium salt dihydrate	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Apoptosis
Sodium citrate dehydrate (Trisodium citrate dihydrate) is a natural product with oral activity that can be found in citrus fruits. Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce *apoptosis. Sodium citrate dehydrate has antibacterial, anti-tumor* and antioxidant activities. Sodium citrate dehydrate can be prepared as a cosolvent or buffer .

HY-N1435

Oroxin B 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Cancer	Apoptosis PI3K PTEN Autophagy
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early *apoptosis* rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-138071

8α-Tigloyloxyhirsutinolide 13-O-acetate 8αTGH	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Dalbergia frutescens (Vell.) Britton	STAT Pyroptosis Apoptosis Reactive Oxygen Species c-Myc Bcl-2 Family TrxR
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, *apoptosis* in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .

HY-N3085

Phellamurin	Flavanonols Phellodendron amurense Rupr. Flavonoids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	P-glycoprotein Apoptosis
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells *apoptosis* and has anti-tumor activity .

HY-N2420

Flavokawain A 1 Publications Verification	Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity. Flavokawain A induces cell *apoptosis* by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer .

HY-N6690

Destruxin B	Infection Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated *apoptosis*, not only in vitro but also in vivo .

HY-N2959

Brevilin A 4 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae Disease Research Fields Cancer	JAK STAT Apoptosis Autophagy
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀= 10.6 µM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce *apoptosis* and autophagy .

HY-N6722

Swainsonine Tridolgosir	Infection Alkaloids Piperidine Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Plants Disease Research Fields Sphaerophysa salsula	Apoptosis Antibiotic
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces *apoptosis* and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .

HY-N0416

Cucurbitacin B 5+ Cited Publications	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Cancer	Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell *apoptosis*. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N0421

Cinobufagin 3 Publications Verification Cinobufagine	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to *apoptosis* in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models .

HY-N12044

Asparanin A	Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides Asparagus officinalis L.	Apoptosis
Asparanin A is an apoptosis inducer with anticancer activity. Asparanin A induces cell cycle arrest in the G0/G1 phase through mitochondria and PI3K/AKT signaling pathways, inhibiting cancer cell growth. Asparanin A also demonstrated in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, significantly inhibiting tumor growth .

HY-N6623

Malvidin-3-galactoside chloride	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Reactive Oxygen Species
Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and *apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor* function .

HY-13062

Daunorubicin hydrochloride Maximum Cited Publications 22 Publications Verification Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces *apoptosis* and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13062A

Daunorubicin Daunomycin; RP 13057; Rubidomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Autophagy Bacterial Antibiotic Apoptosis
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces *apoptosis* and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-N1231

Sophoraflavanone G 1 Publications Verification Kushenol F	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Cancer	Apoptosis
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells *apoptosis* through suppression of MAPK-related pathways .

HY-N11576

Secalonic acid D	Structural Classification Natural Products Microorganisms Classification of Application Fields Sunscreen Source classification Cosmetic Research Disease Research Fields Cancer	Apoptosis GSK-3 c-Myc β-catenin
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell *apoptosis* .

HY-18981

Decursin 1 Publications Verification (+)-Decursin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC.	PKC Apoptosis CXCR
Decursin ((+)-Decursin) is a potent *anti-tumor* agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces *apoptosis* and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities .

HY-117652

Lobetyol	Structural Classification Natural Products Source classification Campanulaceae Plants Lobelia chinensis Lour.	Apoptosis Bcl-2 Family MDM-2/p53
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces *apoptosis* and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity . Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Disease Research Fields Selaginella tamariscina (P. Beauv.) Spring Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces *apoptosis* and cell cycle arrest at sub-G1 phase .

HY-N6950

Hederacolchiside A1 1 Publications Verification	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	PI3K Akt mTOR Parasite Apoptosis
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro .

HY-112328

Fascaplysin	Infection Alkaloids Structural Classification Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	Apoptosis Autophagy Reactive Oxygen Species CDK
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

HY-N3387

Licoricidin	Natural Products Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Apoptosis NF-κB Akt MMP
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, *apoptosis* and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-121618

α-Thujone	Infection Other Monoterpenes Platycladus orientalis (Linn.) Franco Cupressaceae Classification of Application Fields Neurological Disease Terpenoids Source classification Plants Disease Research Fields	GABA Receptor Reactive Oxygen Species Parasite Apoptosis Autophagy
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC₅₀ for α-Thujone is 21 μM in suppressing the *GABA*-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell *apoptosis* and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier .

HY-113505

Delta-12-Prostaglandin J2 Δ12-PGJ2	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce *apoptosis* in HeLa cells via caspase activation .

Cat. No.	Product Name	Chemical Structure

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

HY-10218S

Everolimus-d4
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].

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