2. Anti-infection
  3. Fungal Antibiotic
  4. Anidulafungin

Anidulafungin is a new semisynthetic echinocandin with antifungal potency.

For research use only. We do not sell to patients.

CAS No. : 166663-25-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Anidulafungin:

Anidulafungin Related Antibodies

Top Publications Citing Use of Products

    Anidulafungin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Dec;9(34):e2203088.  [Abstract]

    Anidulafungin (40 µM; 6 h) markedly inhibited PR8 virus replication in A549 cells.

    Anidulafungin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Dec;9(34):e2203088.  [Abstract]

    Anidulafungin (5-40 μM) significantly reduced the ratio of M2/M1 RNA during PR8 virus infection of A549 cells in a dose-dependent manner.

    Anidulafungin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Dec;9(34):e2203088.  [Abstract]

    Anidulafungin (20 mg/kg; p.o.; 12 d) prolonged survival of BALB/c mice infected with PR8 virus, with 80% of mice gaining body weight from day 6 of infection.

    Anidulafungin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Dec;9(34):e2203088.  [Abstract]

    Anidulafungin (20 mg/kg; p.o.; 6 d) significantly decreased infectious progeny from lung tissues of BALB/c mice infected with PR8 virus.

    Anidulafungin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Dec;9(34):e2203088.  [Abstract]

    Anidulafungin (20 mg/kg; p.o.; 6 d) alleviated severe lung pathology in BALB/c mice infected with PR8 virus.

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    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Anidulafungin is a new semisynthetic echinocandin with antifungal potency.

    IC50 & Target

    Antifungal[1]
    Cellular Effect
    Cell Line Type Value Description References
    Vero CC50
    > 50 μM
    Compound: Anidulafungin
    Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
    Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
    		10.1101/2020.03.20.999730
    Vero IC50
    4.64 μM
    Compound: Anidulafungin
    Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
    Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
    		10.1101/2020.03.20.999730
    In Vitro

    Anidulafungin (LY-303366) has MICs of ≤0.32 μg/mL for all Candida albicans (n=99), Candida glabrata (n=18), and Candida tropicalis (n=10) isolates tested. Anidulafungin is also active against Aspergillus species (minimum effective concentration at which 90% of the isolates are inhibited, 0.02 μg/mL) (n=20), is less active against Candida parapsilosis (MIC at which 90% of the isolates are inhibited [MIC90], 5.12 μg/mL) (n=10), and is inactive against C. neoformans (MIC90 >10.24 μg/mL) (n=15) and B. dermatitidis (MIC90, 16 μg/mL) (n=29).The MICs of Fluconazole for three strains of C. tropicalis, seven strains of C. glabrata, and two strains of Candida krusei are ≥16 μg/mL. The MICs of Anidulafungin for 11 of these 12 strains range from 0.08 to 0.32 mg/mL. The twelfth strain is a C. krusei strain (Fluconazole MIC, 32 μg/mL) for which the Anidulafungin MIC is 1.28 mg/mL. The MIC at which 90% of the isolates are inhibited (MIC90) for these 12 strains is 0.32 μg/mL. The Anidulafungin MIC90 for the remaining 18 C. glabrata isolates and C. tropicalis isolates for which the Fluconazole MICs are ≥ 8 μg/mL is also 0.32 mg/mL. Anidulafungin appeares equally active against Candida species for which the fluconazole MICs are ≥16 mg/mL and against those for which the fluconazole MICs are ≥ 8 μg/mL. Anidulafungin has significantly less activity against C. neoformans and B. dermatitidis than against C. albicans, C. glabrata, and C. tropicalis. Ketoconazole and amphotericin B are the most active antifungal agents tested for both C. neoformans and B. dermatitidis. Anidulafungin demonstrated potent in vitro activity against Aspergillus species with a MEC90 of 0.02 μg/mL. MICs of Anidulafungin for the control strain yeast isolates are 0.02 μg/mL for C. albicans ATCC 90028, 0.16 mg/mL for C. glabrata ATCC 90030, and >10.24 μg/mL for C. neoformans ATCC 90112[1]. Strains selected with CD101 that have a 2-fold or greater CD101 MIC increase also have at least a 2-fold MIC increase for Anidulafungin (ANF) and/or Caspofungin (CSF)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Anidulafungin Related Antibodies
    Clinical Trial
    Molecular Weight

    1140.24

    Formula

    C58H73N7O17
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@H]1C[C@H](N2C1)C(N[C@@H]([C@H](O)[C@@H](O)C3=CC=C(O)C=C3)C(N[C@@H]([C@@H](C)O)C(N4[C@@H]([C@@H](O)[C@@H](C)C4)C(N[C@H](O)[C@H](O)C[C@H](NC(C5=CC=C(C6=CC=C(C7=CC=C(OCCCCC)C=C7)C=C6)C=C5)=O)C(N[C@@H]([C@H](O)C)C2=O)=O)=O)=O)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (87.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8770 mL 4.3850 mL 8.7701 mL
    5 mM 0.1754 mL 0.8770 mL 1.7540 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (2.19 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.69%

    SDS (393 KB)

    COA (254 KB) HNMR (332 KB) RP-HPLC (250 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [2]

    Stocks of CD101 (formerly SP 3025, biafungin, AF-025) are prepared fresh in 100% DMSO prior to use. The comparator antifungals Anidulafungin (ANF), Caspofungin (CSF), and Amphotericin B (AMB) are also prepared in 100% DMSO. MIC assays are performed via broth microdilution in accordance with CLSI guidelines, with the exception that test compounds are made up at a 50× final assay concentration and 100 μL assay mixture volumes are used (2 μL added to 98 μL of broth containing cells at 0.5×103 to 2.5×103 CFU/mL). All MIC assays are run at least three times, and a representative data set is shown. Quality control (QC) is assessed throughout the study via comparison of MIC values derived for WT C. krusei strain ATCC 6258 for AMB, CSF, and ANF with previously reported CLSI 24-h broth microdilution QC ranges[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.8770 mL 4.3850 mL 8.7701 mL 21.9252 mL
    5 mM 0.1754 mL 0.8770 mL 1.7540 mL 4.3850 mL
    10 mM 0.0877 mL 0.4385 mL 0.8770 mL 2.1925 mL
    15 mM 0.0585 mL 0.2923 mL 0.5847 mL 1.4617 mL
    20 mM 0.0439 mL 0.2193 mL 0.4385 mL 1.0963 mL
    25 mM 0.0351 mL 0.1754 mL 0.3508 mL 0.8770 mL
    30 mM 0.0292 mL 0.1462 mL 0.2923 mL 0.7308 mL
    40 mM 0.0219 mL 0.1096 mL 0.2193 mL 0.5481 mL
    50 mM 0.0175 mL 0.0877 mL 0.1754 mL 0.4385 mL
    60 mM 0.0146 mL 0.0731 mL 0.1462 mL 0.3654 mL
    80 mM 0.0110 mL 0.0548 mL 0.1096 mL 0.2741 mL
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    Anidulafungin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Anidulafungin166663-25-8LY303366LY 303366LY-303366FungalAntibioticInhibitorinhibitorinhibit

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