1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

ERK

ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway. In the MAPK/ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then MAPK1/2 (below). Ras is typically activated by growth hormones through receptor tyrosine kinases and GRB2/SOS, but may also receive other signals. ERKs are known to activate many transcription factors, such as ELK1, and some downstream protein kinases. Disruption of the ERK pathway is common in cancers, especially Ras, c-Raf and receptors such as HER2.

ERK Related Products (28):

Cat. No. Product Name Effect Purity
  • HY-50846
    SCH772984 Inhibitor 98.06%
    SCH772984 potently inhibits ERK1 and ERK2 activity with IC50 values of 4 and 1 nM, respectively.
  • HY-15947
    GDC-0994 Inhibitor 99.55%
    GDC-0994 is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively.
  • HY-14443
    XMD8-92 Inhibitor 99.62%
    XMD8-92 is a highly selective ERK5/BMK1 inhibitor with dissociation constant (Kd) value of 80 nM.
  • HY-14178
    VX-11e Inhibitor 98.99%
    VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
  • HY-15615A
    TIC10 Inhibitor 99.79%
    TIC10 is a potent, orally active, and stable TRAIL inducer, also inhibits Akt and ERK activity.
  • HY-101846
    AX-15836 Inhibitor 98.95%
    AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM.
  • HY-101494
    LY3214996 Inhibitor 99.87%
    LY3214996 is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays.
  • HY-N1374
    Magnolin Inhibitor
    Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively IC50 & Target: IC50: 16.5 nM (ERK2), 87 nM (ERK1)[1] In Vitro: Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions.
  • HY-12275
    FR 180204 Inhibitor 99.60%
    FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 and ERK2, respectively.
  • HY-19696A
    Tauroursodeoxycholate Sodium Inhibitor 98.02%
    Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by reducing proliferation and inducing apoptosis of smooth muscle cells by suppression of ERK via PKCα-mediated MKP-1 induction.
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.
  • HY-15816
    VRT752271 Inhibitor 99.86%
    VRT752271 is a reversible, ATP-competitive inhibitor of ERK1 and ERK2 kinases, with IC50 of <0.3 nM against ERK2.
  • HY-100627
    APS-2-79 Antagonist 99.21%
    APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
  • HY-N0590
    Corynoxeine Inhibitor 99.91%
    Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation; a useful and prospective compound in the prevention and treatment for vascular diseases.
  • HY-18932
    DEL-22379 Inhibitor 99.84%
    DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM.
  • HY-15665
    XMD17-109 Inhibitor
    XMD17-109 is a novel, specific ERK-5 inhibitor, which inhibits the ERK5-mediated AP1 transcriptional activity at 30 μM, and has an EC50 of 4.2 μM.
  • HY-14403
    ERK5-IN-1 Inhibitor 98.62%
    ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.
  • HY-N2312
    Mogrol Inhibitor 98.06%
    Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
  • HY-N0893
    Tetrahydrocurcumin Inhibitor
    Tetrahydrocurcumin is one of the major metabolites of Curcumin; apoptosis inducer and has been demonstrated to be an antioxidant.
  • HY-N0052A
    Sanguinarine chloride Activator >98.0%
    Sanguinarine (chloride) is natural product.