1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

ERK

ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway. In the MAPK/ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then MAPK1/2 (below). Ras is typically activated by growth hormones through receptor tyrosine kinases and GRB2/SOS, but may also receive other signals. ERKs are known to activate many transcription factors, such as ELK1, and some downstream protein kinases. Disruption of the ERK pathway is common in cancers, especially Ras, c-Raf and receptors such as HER2.

ERK Related Products (24):

Cat. No. Product Name Effect Purity
  • HY-50846
    SCH772984 Inhibitor
    SCH772984 potently inhibits ERK1 and ERK2 activity with IC50 values of 4 and 1 nM, respectively.
  • HY-15947
    GDC-0994 Inhibitor
    GDC-0994 is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively.
  • HY-14443
    XMD8-92 Inhibitor
    XMD8-92 is a highly selective ERK5/BMK1 inhibitor with dissociation constant (Kd) value of 80 nM.
  • HY-14178
    VX-11e Inhibitor
    VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
  • HY-12275
    FR 180204 Inhibitor
    FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively.
  • HY-100627A
    APS-2-79 hydrochloride Antagonist
    APS 2-79 hydrochloride is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site with IC50 values of 120±23 and 418±40 nM for KSR2 and MEK1, respectively.
  • HY-N0431
    Astragaloside IV Inhibitor
    Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
  • HY-N2312
    Mogrol Inhibitor
    Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
  • HY-15615A
    TIC10 Inhibitor
    TIC10 is a potent, orally active, and stable TRAIL inducer, also inhibits Akt and ERK activity.
  • HY-15816
    VRT752271 Inhibitor
    VRT752271 is a pyrrole inhibitors of ERK protein kinase.
  • HY-100627
    APS-2-79 Antagonist
    APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
  • HY-19696A
    Tauroursodeoxycholate Sodium Inhibitor
    Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by reducing proliferation and inducing apoptosis of smooth muscle cells by suppression of ERK via PKCα-mediated MKP-1 induction.
  • HY-14403
    ERK5-IN-1 Inhibitor
    ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.
  • HY-15665
    XMD17-109 Inhibitor
    XMD17-109 is a novel, specific ERK-5 inhibitor, which inhibits the ERK5-mediated AP1 transcriptional activity at 30 μM, and has an EC50 of 4.2 μM.
  • HY-N0590
    Corynoxeine Inhibitor
    Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation; a useful and prospective compound in the prevention and treatment for vascular diseases.
  • HY-18932
    DEL-22379 Inhibitor
    DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM.
  • HY-N0893
    Tetrahydrocurcumin Inhibitor
    Tetrahydrocurcumin is one of the major metabolites of Curcumin; apoptosis inducer and has been demonstrated to be an antioxidant.
  • HY-N2149
    Tomatidine Inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB. possess anti-inflammatory properties. a novel small molecule inhibitor of muscle atrophy.
  • HY-N0052A
    Sanguinarine chloride Activator
    Sanguinarine (chloride) is natural product.
  • HY-N0052
    Sanguinarine Activator
    Sanguinarine(Pseudochelerythrine) is a benzophenanthridine alkaloid which has anti-microbial, anti-oxidant and anti-inflammatory properties; specific inhibitor of Rac1b.