1. PI3K/Akt/mTOR
  2. mTOR

mTOR

mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. mTOR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. mTOR integrates the input from upstream pathways, including insulin, growth factors and amino acids. mTOR also senses cellular nutrient, oxygen, and energy levels. The mTOR pathway is dysregulated in human diseases, such as diabetes, obesity, depression, and certain cancers. Rapamycin inhibits mTOR by associating with its intracellular receptor FKBP12. The FKBP12-rapamycin complex binds directly to the FKBP12-Rapamycin Binding (FRB) domain of mTOR, inhibiting its activity.

mTOR Related Products (50):

Cat. No. Product Name Effect Purity
  • HY-10219
    Rapamycin Inhibitor
    Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM.
  • HY-10218
    Everolimus Inhibitor
    Everolimus is a targeted, highly specific agent with an IC50 for binding to isolated FKBP-12, or FKBP-12 complexed to mTOR of 5 to 6 nM, and no significant activity against other protein kinases.
  • HY-16046
    AP1903 Chemical
    AP1903 is a homodimer binding to FKBP, elicits potent and dose-dependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM.
  • HY-50673
    BEZ235 Inhibitor
    BEZ235 is a dual pan-class I PI3K and mTOR kinase inhibitor with IC50 of 4 nM/5 nM/7 nM/75 nM, and 6 nM for p110α/γ/δ/β and mTOR (p70S6K), respectively.
  • HY-13328
    INK-128 Inhibitor
    INK-128 is a potent and selective mTOR inhibitor with IC50 of 1 nM, > 200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes.
  • HY-100222
    CZ415 Inhibitor
    CZ415 is a potent and highly selective mTOR inhibitor.
  • HY-100026
    PQR620 Inhibitor
    PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo.
  • HY-10422
    AZD-8055 Inhibitor
    AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase activity, with an IC50 of 0.8 nM.
  • HY-13003
    Torin 1 Inhibitor
    Torin 1 is a potent inhibitor of mTORC, with IC50 values of 2 nM and 10 nM against mTORC1 and mTORC2, respectively.
  • HY-13992
    AP20187 Modulator
    AP20187 is a cell-permeable molecule used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
  • HY-B0795
    MHY1485 Activator
    MHY1485 is a mTOR activator, which also is an inhibitor of autophagy.
  • HY-12513
    LY3023414 Inhibitor
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).
  • HY-13002
    Torin 2 Inhibitor
    Torin 2 is a mTOR inhibitor with EC50 of 0.25 nM, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM).
  • HY-15177
    PF-04691502 Inhibitor
    PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity. PF-04691502 inhibits human and mouse PI3Kα with Ki of 1.8 and 1.2 nM, respectively, human PI3K isoforms β, δ, and γ with Ki of 2.1, 1.6, and 1.9 nM, respectively, and human mTOR with Ki of 16 nM.
  • HY-10474
    PP 242 Inhibitor
    PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM.
  • HY-15247
    AZD2014 Inhibitor
    AZD2014 is a small-molecule ATP competitive mTOR inhibitor with IC50 of 2.81 nM.
  • HY-50908
    Deforolimus Inhibitor
    Deforolimus(AP23573; MK-8669; Ridaforolimus) is a selective mTOR inhibitor with IC50 of 0.2 nM; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin.
  • HY-10297
    GSK2126458 Inhibitor
    GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.
  • HY-50710
    KU-0063794 Inhibitor
    KU-0063794 is a potent and highly specific dual-mTOR inhibitor, with IC50 of appr 10 nM for mTORC1 and mTORC2 in cell-free assays, but has no effect on PI3Ks.
  • HY-50910
    Temsirolimus Inhibitor
    Temsirolimus is an inhibitor of mTOR with IC50 value of 1.76 μM.