2. Signaling Pathways
  3. Apoptosis
  4. Paraptosis

Paraptosis

 

Paraptosis Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-115901
    4-PQBH
    		99.08%
    4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research.
    4-PQBH
  • HY-155719
    fac-[Re(CO)3(L3)(H2O)][NO3]
    		Inducer
    fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC50=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy.
    fac-[Re(CO)3(L3)(H2O)][NO3]