1. Epigenetics
    TGF-beta/Smad
  2. PKC

PKC

PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Related Products (27):

Cat. No. Product Name Effect Purity
  • HY-15141
    Staurosporine Inhibitor 99.98%
    Staurosporine is a very potent universal inhibitor of protein kinases but showing little selectivity, with IC50 of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase, respectively.
  • HY-18739
    Phorbol 12-myristate 13-acetate Activator 99.08%
    Phorbol 12-myristate 13-acetate (PMA) is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.
  • HY-10230
    PKC412 Inhibitor 98.60%
    PKC412 is an inhibitor of protein kinase C (PKC) and can inhibit other kinases including PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR.
  • HY-13689
    Go 6983 Inhibitor >98.0%
    Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.
  • HY-10341
    Fasudil Hydrochloride Inhibitor 99.92%
    Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
  • HY-P0265
    β-Amyloid 1-40
    β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.
  • HY-101569
    LXS196 Inhibitor 99.25%
    LXS196 is a potent and orally active protein kinase C (PKC) inhibitor under Phase I clinical trials for the treatment of uveal melanoma.
  • HY-12048
    Chelerythrine Chloride Inhibitor >98.0%
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C and mitogen-activated protein kinase (MAPK), with IC50 of 660 nM for PKC, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
  • HY-10343
    Sotrastaurin Inhibitor 99.70%
    Sotrastaurin is a potent pan-PKC inhibitor, with Kis of 0.22 nM, 0.64nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.
  • HY-10342
    Enzastaurin Inhibitor 99.84%
    Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε.
  • HY-13866
    Ro 31-8220 mesylate Inhibitor 99.50%
    Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively.
  • HY-13867
    Bisindolylmaleimide I Inhibitor 98.04%
    Bisindolylmaleimide I (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki of 14 nM.
  • HY-11009
    CGP60474 Inhibitor 99.22%
    CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP.
  • HY-13777A
    Zoledronic acid monohydrate Activator 99.55%
    Zoledronic acid monohydrate(CGP 42446; ZOL 446) is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines.
  • HY-13772
    Valrubicin Activator 99.51%
    Valrubicin (AD-32) is a chemotherapy drug used to treat bladder cancer.
  • HY-B0719
    Ingenol Mebutate Activator 98.74%
    Ingenol Mebutate (PEP 005) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
  • HY-10195B
    Ruboxistaurin hydrochloride Inhibitor 99.54%
    Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily.
  • HY-18931A
    NSC305787 hydrochloride Inhibitor 98.70%
    NSC305787 hydrochloride is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.
  • HY-N0021
    Verbascoside Inhibitor
    Verbascoside(Acteoside; TJC160), is a bioactive polyphenol from olive oil mill wastewater with known antioxidant activity; protein kinase C inhibitor (IC50 =25 uM).
  • HY-12307
    (-)-Indolactam V Activator 99.18%
    (-)-Indolactam V (ILV) is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.