1. Protein Tyrosine Kinase/RTK
  2. IGF-1R

IGF-1R

IGF-1R (Insulin-like growth factor 1 receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice carrying only one functional copy of IGF-1R are normal, but exhibit a ~15% decrease in body mass. The IGF-1R is implicated in several cancers, including breast, prostate, and lung cancers. In some instances its anti-apoptotic properties allow cancerous cells to resist the cytotoxicproperties of chemotherapeutic drugs or radiotherapy.

IGF-1R Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-15656
    LDK378 Inhibitor
    LDK378 is a potent and more specific ALK inhibitor with IC50 of 0.2 nM.
  • HY-10191
    Linsitinib Inhibitor
    Linsitinib is a selective inhibitor of IGF-1R with IC50 of 35 nM, and modestly potent to InsR with IC50 of 75 nM, and has no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc.
  • HY-10200
    BMS-754807 Inhibitor
    BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc.
  • HY-50866
    NVP-AEW541 Inhibitor
    NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM.
  • HY-15494
    AXL1717 Inhibitor
    AXL1717 is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM.
  • HY-10262
    BMS-536924 Inhibitor
    BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM.
  • HY-13686
    PQ401 Inhibitor
    PQ401, a selective insulin-like growth factor-1 receptor blocker, is a novel diarylurea compound that inhibits IGF1R autophosphorylation with IC50 < 1 uM.
  • HY-10253
    AG1024 Inhibitor
    AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.
  • HY-13020
    GSK1838705A Inhibitor
    GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively.
  • HY-15749
    XL228 Inhibitor
    XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.
  • HY-10252
    NVP-ADW742 Inhibitor
    NVP-ADW742(ADW742; GSK 552602A ) is an selective IGF-1R inhibitor with IC50 of 0.17 (mu)M, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
  • HY-10524
    GSK1904529A Inhibitor
    GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.
  • HY-15609
    AZD-3463 Inhibitor
    AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib.