1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad

TGF-beta/Smad

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

TGF-beta/Smad Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-B0673
    Pirfenidone Inhibitor 99.98%
    Pirfenidone leads to a reduction of TGF-β2 mRNA levels and of the mature TGF-β2 protein due to decreased expression and direct inhibition of the TGF-β pro-protein convertase furin.
  • HY-13013
    SIS3 Inhibitor >98.0%
    SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter.
  • HY-16268
    Kartogenin >98.0%
    Kartogenin is an inducer of differentiation of human mesenchymal stem cells into chondrocytes.
  • HY-P0118
    Disitertide Inhibitor 98.12%
    Disitertide also named P144, is a inhibitor of TGF-β1.
  • HY-N1584
    Halofuginone Inhibitor
    Halofuginone is a plant derivative that has been shown to inhibit Th17 differentiation, and recently tested as a potential immunosuppressant.
  • HY-100347A
    SRI-011381 hydrochloride Agonist 99.66%
    SRI-011381 hydrochloride is a TGF-beta signaling agonist.
  • HY-N0158
    Oxymatrine Inhibitor >98.0%
    Oxymatrine, an alkaloid from the roots of Sophora species, with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway.
  • HY-B0252
    Hydrochlorothiazide Inhibitor 99.17%
    Hydrochlorothiazide is a diuretic drug of the thiazide class.
  • HY-N2033
    Chebulinic acid Inhibitor
    Chebulinic acid is a potent natural inhibitor of M.