1. Apoptosis
  2. Caspase

Caspase

Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. There are two types of apoptotic caspases: initiator (apical) caspases and effector (executioner) caspases. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them. Effector caspases (e.g., CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process. The initiation of this cascade reaction is regulated by caspase inhibitors. CASP4 and CASP5, which are overexpressed in some cases of vitiligo and associated autoimmune diseases caused by NALP1 variants, are not currently classified as initiator or effector in MeSH, because they are inflammatory enzymes that, in concert with CASP1, are involved in T-cell maturation.

Caspase Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-16658
    Z-VAD-FMK Inhibitor
    Z-VAD-FMK is a cell-permeable, pan-caspase inhibitor.
  • HY-13251
    Silvestrol Activator
    Silvestrol is isolated from the fruits and twigs of Aglaia foveolata, by inducing caspase-3 activation to cause cell death.
  • HY-13205
    VX-765 Inhibitor
    VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor, inhibits IL-1β release with similar potency in PBMCs from FCAS (IC50=0.99±0.29 μM) and control (IC50=1.1±0.61 μM) subjects.
  • HY-12466
    Z-DEVD-FMK Inhibitor
    Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 μM.
  • HY-13010
    Laquinimod Inhibitor
    Laquinimod is a potent immunomodulator.
  • HY-N2027
    Taurochenodeoxycholic acid Activator
    Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
  • HY-12305
    Q-VD-OPh Inhibitor
    Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 1, 3, 8 and 9 with IC50 values of 50, 25, 100, and 430 nM, respectively.
  • HY-100844
    ASK1-IN-1 Inhibitor
    ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.
  • HY-13523
    PAC-1 Activator
    PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
  • HY-18938
    Selonsertib Inhibitor
    GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
  • HY-13229
    BOC-D-FMK Inhibitor
    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
  • HY-19566
    NQDI-1 Inhibitor
    NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM.