1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

Tauroursodeoxycholate Sodium (Synonyms: Sodium tauroursodeoxycholate; Tauroursodeoxycholic acid sodium salt)

Cat. No.: HY-19696A Purity: 98.02%
Data Sheet SDS Handling Instructions

Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by reducing proliferation and inducing apoptosis of smooth muscle cells by suppression of ERK via PKCα-mediated MKP-1 induction.

For research use only. We do not sell to patients.
Tauroursodeoxycholate Sodium Chemical Structure

Tauroursodeoxycholate Sodium Chemical Structure

CAS No. : 35807-85-3

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  • Technical Information

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Description

Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by reducing proliferation and inducing apoptosis of smooth muscle cells by suppression of ERK via PKCα-mediated MKP-1 induction. Target: ERK [1] in vitro: Tauroursodeoxycholate (TUDCA) is a cytoprotective agent in a variety of cells including hepatocytes as well as an inducer of apoptosis in cancer cells. In this study, we investigated whether TUDCA could prevent neointimal hyperplasia by suppressing the growth and migration of VSMCs. TUDCA suppresses both viability and migration of VSMCs through inhibition of ERK phosphorylation, by induction of MKP-1 via PKCα. TUDCA suppresses the PDGF-mediated proliferation and migration of VSMCs. [1] in vivo: The membrane translocation of PKCα by TUDCA induced inhibition of cholangiocyte proliferation in bile duct-ligated rats. [1]

References
Molecular Weight

521.69

Formula

C₂₆H₄₄NNaO₆S

CAS No.

35807-85-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 39 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Tauroursodeoxycholate Sodium
Cat. No.:
HY-19696A
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