1. Stem Cell/Wnt
  2. Notch

Notch

Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as Notch1, Notch2, Notch3, and Notch4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. The notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life.

Notch Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-10009
    Semagacestat Inhibitor
    Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM.
  • HY-100431
    IMR-1 Inhibitor
    IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 (mu)mol/L.
  • HY-N0133
    Tangeretin Inhibitor
    Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.
  • HY-15860
    FLI-06 Inhibitor
    FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM.
  • HY-12449
    LY3039478 Inhibitor
    LY3039478 is a novel and potent Notch inhibitor.
  • HY-13526
    YO-01027 Inhibitor
    YO-01027 (Dibenzazepine;DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92±0.22 and 2.64±0.30 nM for Notch and APPL cleavage, respectively.
  • HY-12465
    Z-Ile-Leu-aldehyde Inhibitor
    Z-Ile-Leu-aldehyde(Z-IL-CHO; GSI-XII) is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
  • HY-100431A
    IMR-1A Inhibitor
    IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 (mu)mol/L.
  • HY-N0232
    Psoralidin Inhibitor
    Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. possessing anti-cancer properties.
  • HY-12419
    BMS-983970 Inhibitor
    BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.