1. Stem Cell/Wnt
  2. Notch

Notch

Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as Notch1, Notch2, Notch3, and Notch4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. The notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life.

Notch Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-11102
    RO4929097 Inhibitor 98.02%
    RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively.
  • HY-50752
    LY-411575 Inhibitor 99.22%
    LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), and also inhibits Notch S3 cleavage with IC50 of 0.39 nM.
  • HY-50845
    BMS-708163 Inhibitor 99.95%
    BMS-708163 is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM.
  • HY-10009
    Semagacestat Inhibitor 98.90%
    Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM.
  • HY-12449
    LY3039478 Inhibitor 98.01%
    LY3039478 is a novel and potent Notch inhibitor.
  • HY-13526
    YO-01027 Inhibitor 98.22%
    YO-01027 (Dibenzazepine;DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92±0.22 and 2.64±0.30 nM for Notch and APPL cleavage, respectively.
  • HY-N0133
    Tangeretin Inhibitor 98.98%
    Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.
  • HY-100431
    IMR-1 Inhibitor 99.13%
    IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.
  • HY-12419
    BMS-983970 Inhibitor 99.04%
    BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.
  • HY-15860
    FLI-06 Inhibitor 98.06%
    FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM.
  • HY-100431A
    IMR-1A Inhibitor 98.06%
    IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.
  • HY-12465
    Z-Ile-Leu-aldehyde Inhibitor
    Z-Ile-Leu-aldehyde(Z-IL-CHO; GSI-XII) is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
  • HY-N0232
    Psoralidin Inhibitor
    Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L.