1. Stem Cell/Wnt
  2. Wnt

Wnt

The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three Wnt signaling pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the protein Dishevelled inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell, and the noncanonical Wnt/calcium pathway regulates calcium inside the cell. The clinical importance of Wnt signaling pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes.

Wnt Related Products (20):

Cat. No. Product Name Effect Purity
  • HY-14428
    ICG-001 Inhibitor
    ICG-001 is an antagonist of Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM.
  • HY-15597
    Salinomycin Inhibitor
    Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex. Salinomycin strongly suppresses Wnt1-stimulated reporter activity with an IC50 of 163 nM, and reduces β-catenin levels.
  • HY-12238
    IWR-1 Inhibitor
    IWR-1 is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, and induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
  • HY-18988
    ETC-159 Inhibitor
    ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
  • HY-13912
    IWP-2 Inhibitor
    IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM.
  • HY-10593
    IQ-1 Inhibitor
    IQ-1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.
  • HY-A0293
    Pyrvinium pamoate Inhibitor
    Pyrvinium pamoate, a well-known anthelmintic drug, acts as a selective WNT pathway inhibitor.
  • HY-101130
    PNU-74654 Inhibitor
    PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.
  • HY-12681
    CCT251545 Inhibitor
    CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.
  • HY-15659
    Wnt-C59 Inhibitor
    Wnt-C59 is a potent PORCN enzymatic activity and Wnt inhibitor.
  • HY-19987
    BML-284 Activator
    BML-284 is potent selective, and cell-permeable Wnt signaling activator.
  • HY-16665
    iCRT 14 Inhibitor
    iCRT 14 is a novel potent inhibitor of (beta)-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity).
  • HY-17577
    Berberine chloride hydrate Activator
    Berberine has shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells; MAPK and Wnt/β-catenin pathways affected by Berberine.
  • HY-15721
    FH535 Inhibitor
    FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
  • HY-12637
    Hexachlorophene Inhibitor
    Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 (plusmn) 1.29 (mu)M; also is an inhibitor of Wnt/beta-catenin signaling.
  • HY-13815
    KY02111 Inhibitor
    KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes.
  • HY-19739
    JW74 Inhibitor
    JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.
  • HY-12319A
    Cardiogenol C hydrochloride Activator
    Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
  • HY-18258
    Berberine chloride Activator
    Berberine has shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells; MAPK and Wnt/(beta)-catenin pathways affected by Berberine.
  • HY-32736
    Triptonide Inhibitor
    Triptonide(NSC 165677; PG 492), extracted from Tripterygium wilfordii Hook, inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 mg/ml.