1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    TGF-beta/Smad
  2. ROCK

ROCK

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus, invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ROCK consists of a kinase domain, acoiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present. ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small GTPase Rho, which is one of the major regulators of the cytoskeleton.

ROCK Related Products (29):

Cat. No. Product Name Effect Purity
  • HY-10583
    Y-27632 dihydrochloride Inhibitor 98.53%
    Y-27632 2Hcl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
  • HY-10071
    Y-27632 Inhibitor 99.65%
    Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively.
  • HY-15307
    SLx-2119 Inhibitor 99.36%
    SLx-2119 is a selective inhibitor of ROCK2 with IC50 of 105 nM, more than 200 fold selecivity over ROCK1 (IC50=24 μM).
  • HY-16563
    Narciclasine Activator 99.94%
    Narciclasine is a plant growth modulator.
  • HY-10341
    Fasudil Hydrochloride Inhibitor 99.92%
    Fasudil (Hydrochloride) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
  • HY-12437
    BDP5290 Inhibitor >98.0%
    BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCK1 and MRCK2, respectively.
  • HY-U00351
    ROCK-IN-1 Inhibitor
    ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2.
  • HY-10069
    Y-33075 dihydrochloride Inhibitor 98.37%
    Y-33075 dihydrochloride is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632.
  • HY-15556
    GSK269962A Inhibitor 98.01%
    GSK269962A is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively.
  • HY-11000
    GSK429286A Inhibitor 99.13%
    GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 values of 14 nM and 63 nM, respectively.
  • HY-12659
    LX7101 Inhibitor 99.58%
    LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM.
  • HY-10319
    ROCK inhibitor Inhibitor 99.17%
    ROCK inhibitor(azaindole 1) is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.
  • HY-13257
    Thiazovivin Inhibitor 99.32%
    Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5 μM, promotes hESC survival after single-cell dissociation.
  • HY-15685
    K-115 Inhibitor 98.38%
    K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension.
  • HY-13300
    SR-3677 Inhibitor 99.46%
    SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.
  • HY-15755
    RKI-1447 Inhibitor 98.05%
    RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 values of 14.5 nM and 6.2 nM, respectively.
  • HY-15392
    chroman 1 Inhibitor 99.76%
    chroman 1 is a highly potent and selective ROCK II inhibitor.
  • HY-15720A
    H-1152 dihydrochloride Inhibitor >98.0%
    H-1152 2Hcl, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
  • HY-18990
    GSK180736A Inhibitor 98.05%
    GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
  • HY-15687
    SAR407899 hydrochloride Inhibitor 99.81%
    SAR407899 Hcl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.