1. PI3K/Akt/mTOR
  2. PI3K

PI3K

PI3K (Phosphatidylinositol-4,5-bisphosphate 3-kinase) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. Many of these functions relate to the ability of class I PI3-kinases to activate protein kinase B (PKB, Akt) as in the PI3K/AKT/mTOR pathway. The p110δ and p110γ isoforms regulate different aspects of immune responses. PI 3-kinases are also a key component of the insulin signaling pathway. PI3Ks are a family of related intracellularsignal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).

PI3K Related Products (90):

Cat. No. Product Name Effect Purity
  • HY-10108
    LY294002 Inhibitor 99.97%
    LY294002 is a broad-spectrum inhibitor of PI3K, with IC50 of 0.5/0.57/0.97 μM for PI3Kα/δ/β, respectively, also potently inhibits CK2 with IC50 of 98 nM.
  • HY-19312
    3-Methyladenine Inhibitor 99.84%
    3-Methyladenine is a selective PI3K inhibitor with IC50 of 25 μM and 60 μM for Vps34 and PI3Kγ, respectively, and it can inhibit all PtdIns3Ks at 10 mM.
  • HY-10197
    Wortmannin Inhibitor 99.33%
    Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50s of 3 nM and 170 nM, respectively.
  • HY-50673
    BEZ235 Inhibitor 98.83%
    BEZ235 is a dual pan-class I PI3K and mTOR kinase inhibitor with IC50 of 4 nM/5 nM/7 nM/75 nM, and 6 nM for p110α/γ/δ/β and mTOR (p70S6K), respectively.
  • HY-13328
    INK-128 Inhibitor 99.55%
    INK-128 is a potent and selective mTOR inhibitor with IC50 of 1 nM, > 200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes.
  • HY-12794
    Vps34-PIK-III Inhibitor 99.06%
    Vps34-PIK-III is a potent and selective inhibitor of VPS34 with an IC50 of 18 nM.
  • HY-17645
    Tenalisib Inhibitor
    Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively.
  • HY-15244
    BYL-719 Inhibitor 99.04%
    BYL-719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM.
  • HY-70063
    NVP-BKM120 Inhibitor 99.68%
    NVP-BKM120 is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.
  • HY-13026
    CAL-101 Inhibitor 98.38%
    CAL-101 is a highly selective and potent p110δ inhibitor with IC50 of 2.5 nM, is 40- to 300-fold more selective for p110δ relative to other PI3K class I enzymes (p110α, p110β, and p110γ; IC50 are 820, 565, and 89nM, respectively).
  • HY-100716
    IPI549 Inhibitor 99.14%
    IPI549 is a potent and selective PI3Kγ Inhibitor with IC50 of 16 nM.
  • HY-12481
    SAR405 Inhibitor 98.48%
    SAR405 is highly potent and selective inhibitor of PIK3C3 with an IC50 of 27 nM.
  • HY-50094
    GDC-0941 Inhibitor 99.52%
    GDC-0941 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
  • HY-18085
    Quercetin Inhibitor 98.21%
    Quercetin is a flavonoid with anticancer activity; mitochondrial ATPase and phosphodiesterase inhibitor and Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity.
  • HY-12795
    Vps34-IN-1 Inhibitor 99.64%
    Vps34-IN-1 is an inhibitor of Vps34 extracted from patent WO/2012085815 A1, compound example 16a; has an IC50 of 4 nM.
  • HY-12279
    TGR-1202 Inhibitor 98.55%
    TGR-1202 is a novel PI3Kδ inhibitor, with IC50 and EC50 of 22.2 nM and 24.3 nM, respectively; Also active against CK1ε, with an EC50 value of 6.0 μM.
  • HY-12513
    LY3023414 Inhibitor 99.70%
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).
  • HY-15346
    BAY 80-6946 Inhibitor 98.09%
    BAY 80-6946 is an ATP-competitive selective class-I PI3 kinases inhibitor, with IC50s of 0.5, 0.7, 3.7 and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, and much less active against mTOR (IC50=45 nM) and other PIKs (no inhibition at 1 μM).
  • HY-13898
    GDC-0032 Inhibitor 99.75%
    GDC-0032 is a potent β-sparing small molecule inhibitor of PI3K, with IC50 values of 0.29 nM, 0.91 nM, 0.97 nM for PI3Kα, PI3Kβ and PI3Kγ, respectively.
  • HY-15177
    PF-04691502 Inhibitor 98.58%
    PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.