1. PI3K/Akt/mTOR
  2. PI3K

PI3K

PI3K (Phosphatidylinositol-4,5-bisphosphate 3-kinase) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. Many of these functions relate to the ability of class I PI3-kinases to activate protein kinase B (PKB, Akt) as in the PI3K/AKT/mTOR pathway. The p110δ and p110γ isoforms regulate different aspects of immune responses. PI 3-kinases are also a key component of the insulin signaling pathway. PI3Ks are a family of related intracellularsignal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).

PI3K Related Products (83):

Cat. No. Product Name Effect Purity
  • HY-10108
    LY294002 Inhibitor
    LY294002 is a broad-spectrum inhibitor of PI3K, with IC50 of 0.5/0.57/0.97 μM for PI3Kα/δ/β, respectively, also potently inhibits CK2 with IC50 of 98 nM.
  • HY-50673
    BEZ235 Inhibitor
    BEZ235 is a dual pan-class I PI3K and mTOR kinase inhibitor with IC50 of 4 nM/5 nM/7 nM/75 nM, and 6 nM for p110α/γ/δ/β and mTOR (p70S6K), respectively.
  • HY-13328
    INK-128 Inhibitor
    INK-128 is a potent and selective mTOR inhibitor with IC50 of 1 nM, > 200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes.
  • HY-10197
    Wortmannin Inhibitor
    Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50s of 3 nM and 170 nM, respectively.
  • HY-70063
    NVP-BKM120 Inhibitor
    NVP-BKM120 is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.
  • HY-13026
    CAL-101 Inhibitor
    CAL-101 is a highly selective and potent p110δ inhibitor with IC50 of 2.5 nM, is 40- to 300-fold more selective for p110δ relative to other PI3K class I enzymes (p110α, p110β, and p110γ; IC50 are 820, 565, and 89nM, respectively).
  • HY-50094
    GDC-0941 Inhibitor
    GDC-0941 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
  • HY-10297
    GSK2126458 Inhibitor
    GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.
  • HY-10115A
    PI-103 Hydrochloride Inhibitor
    PI-103 hydrochloride is a potent PI3K/Akt and mTOR inhibitor with IC50 values of 2 nM for recombinant PI3K isoform p110α and 30 nM for mTOR.
  • HY-10109
    AS-605240 Inhibitor
    AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM).
  • HY-10114
    TGX-221 Inhibitor
    TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β .
  • HY-12046
    PIK-93 Inhibitor
    PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3Kα with IC50 of 39 nM.
  • HY-13261
    A66 Inhibitor
    A66 is a highly specific and selective p110α inhibitor with IC50 of 32 nM.
  • HY-13246
    GDC-0980 Inhibitor
    GDC-0980 is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively, and also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases.
  • HY-10111
    TG100-115 Inhibitor
    TG100–115 is a PI3K γ and -δ inhibitor (IC50 = 83 and 235 nM, respectively)
  • HY-50847
    ZSTK474 Inhibitor
    ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM, mostly PI3Kδ.
  • HY-10110
    IC-87114 Inhibitor
    IC-87114 was the first isoform-selective PI3K inhibitor. p110δ(IC50 = 0.13 μM) vs. p110α(IC50 = 200 μM), p110β(IC50 = 16 μM) and p110γ(IC50 = 61 μM).
  • HY-10344
    AZD 6482 Inhibitor
    AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ.
  • HY-12030
    PIK-90 Inhibitor
    PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ(IC50= 350 nM).
  • HY-13334
    NVP-BGT226 Inhibitor
    NVP-BGT226(BGT 226) is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM.