1. Apoptosis
  2. Survivin

Survivin

Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. Survivin expression is highly regulated by the cell cycle and is only expressed in the G2-M phase. Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Survivin is highly expressed in most cancers and associated with chemotherapy resistance, increased tumor recurrence, and shorter patient survival, making antisurvivin therapy an attractive cancer treatment strategy.

Survivin Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-10194
    YM-155 Inhibitor >98.0%
    YM155 (Sepantronium bromide) is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
  • HY-10194A
    YM-155 hydrochloride Inhibitor
    YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
  • HY-U00177
    GDP366 Inhibitor
    GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.