1. NF-κB
  2. NF-κB

NF-κB

NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. There are five proteins in the mammalian NF-κB family: NF-κB1, NF-κB2, RelA, RelB, c-Rel.

NF-κB Related Products (67):

Cat. No. Product Name Effect Purity
  • HY-13453
    BAY 11-7082 Inhibitor 99.64%
    BAY 11-7082 is a NF-κB inhibitor.
  • HY-13982
    JSH-23 Inhibitor 99.10%
    JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.
  • HY-18738
    Pyrrolidinedithiocarbamate ammonium Inhibitor >98.0%
    Pyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor.
  • HY-14645
    (-)-DHMEQ Inhibitor 98.05%
    (-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A).
  • HY-N0141
    Parthenolide Inhibitor 99.13%
    Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.
  • HY-10257
    BAY 11-7085 Inhibitor 98.84%
    BAY 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM.
  • HY-N0298
    Stachydrine Inhibitor >98.0%
    Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis.
  • HY-P0151
    SN50 Inhibitor
    SN50 is a cell permeable inhibitor of NF-κB.
  • HY-N0176
    Dihydroartemisinin Inhibitor >98.0%
    Dihydroartemisinin, one of the most active artemisinin derivative, exhibits anticancer activity in a number of human cancer cells.
  • HY-N0904
    Ginsenoside C-K Inhibitor 98.06%
    Ginsenoside C-K(Ginsenoside compound K) is an intestinal microbiota metabolite of ginsenoside Rb1; possessing anti-proliferative and anti-inflammatory activities.
  • HY-13812
    QNZ Inhibitor 99.00%
    QNZ(EVP4593) is a derivative of 6-aminoquinazoline class that has been previously isolated as an inhibitor of PMA/PHA-induced NF-κB pathway activation in Jurkat cells (IC50= 9 nM).
  • HY-12212
    RTA-408 Inhibitor 98.96%
    RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB.
  • HY-14655
    Sulfasalazine Inhibitor >98.0%
    Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis.
  • HY-N0191
    Andrographolide Antagonist
    Andrographolide(Andrographis) is an irreversible antagonist of NF-κB and prevents in vitro T cell activation; displays antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties.
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.
  • HY-N0197
    Baicalin Inhibitor 98.01%
    Baicalin, one the effective compositions of scutellaria baicalensis, possesses multiple properities such as antioxidant, anti-tumor, anti-HIV, treating cardiovascular disease and so on.
  • HY-19387
    Didox Inhibitor
    Didox is a strong inhibitor of ribonucleotide reductase (RR) that interferes with DNA synthesis and repair by blocking the production of deoxyribonucleotides and has demonstrated antitumor effects for decades.
  • HY-N0039
    Ginsenoside Rb1 Inhibitor 98.10%
    Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
  • HY-N0045
    Ginsenoside Rg1 Inhibitor >98.0%
    Ginsenoside Rg1 is part of a class of triterpene saponins and steroid glycosides; possess anti-inflammatory and anticancer activities.
  • HY-N0441
    Neferine Inhibitor 99.92%
    Neferine, is a major alkaloid present in the green embryos of Nelumbo nucifera Gaertn with anti-arrhythmia, anti-hypertensive and vaso-relaxant properties , also a NF-κB inhibitor.