1. NF-κB
  2. NF-κB

NF-κB

NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. There are five proteins in the mammalian NF-κB family: NF-κB1, NF-κB2, RelA, RelB, c-Rel.

NF-κB Related Products (58):

Cat. No. Product Name Effect Purity
  • HY-13453
    BAY 11-7082 Inhibitor
    BAY 11-7082 is a NF-κB inhibitor. BAY 11-7082 inhibits ubiquitin-specific protease (USP)7 and 21 with an IC50 of 0.19 μM and 0.96 μM, respectively.
  • HY-13982
    JSH-23 Inhibitor
    JSH-23 is an inhibitor of NF-κB with an IC50 value of 7.1 μM.
  • HY-N0141
    Parthenolide Inhibitor
    Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.
  • HY-14645
    (-)-DHMEQ Inhibitor
    (-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A).
  • HY-13812
    QNZ Inhibitor
    QNZ(EVP4593) is a derivative of 6-aminoquinazoline class that has been previously isolated as an inhibitor of PMA/PHA-induced NF-κB pathway activation in Jurkat cells (IC50= 9 nM).
  • HY-N0298
    Stachydrine Inhibitor
    Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis.
  • HY-N0145
    Puerarin Inhibitor
    Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
  • HY-N0176
    Dihydroartemisinin Inhibitor
    Dihydroartemisinin, one of the most active artemisinin derivative, exhibits anticancer activity in a number of human cancer cells.
  • HY-14655
    Sulfasalazine Inhibitor
    Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis.
  • HY-N0191
    Andrographolide Antagonist
    Andrographolide(Andrographis) is an irreversible antagonist of NF-κB and prevents in vitro T cell activation; displays antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties.
  • HY-N0045
    Ginsenoside Rg1 Inhibitor
    Ginsenoside Rg1 is part of a class of triterpene saponins and steroid glycosides; possess anti-inflammatory and anticancer activities.
  • HY-N0441
    Neferine Inhibitor
    Neferine, is a major alkaloid present in the green embryos of Nelumbo nucifera Gaertn with anti-arrhythmia, anti-hypertensive and vaso-relaxant properties , also a NF-κB inhibitor.
  • HY-N0039
    Ginsenoside Rb1 Inhibitor
    Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
  • HY-N0290
    Mangiferin Inhibitor
    Mangiferin isolated from Anemarrhena asphodeloides Bunge rhizome, is used for antidiabetes.
  • HY-15530
    CID-2858522 Inhibitor
    CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.
  • HY-N0040
    Ginsenoside Rb2 Inhibitor
    Ginsenoside Rb2 is a 20(S)-protopanaxadiol glycoside extracted from ginseng, shows potent antioxidant and anticancer biological activities.
  • HY-13719
    Oleandrin Inhibitor
    Oleandrin (a toxic cardiac glycoside of N. oleander L.) inhibits the activity of NF-κB in various cultured cell lines (U937, CaOV3, human epithelial cells and T cells) as well as it induces programmed cell death in PC3 cell line culture.
  • HY-N0197
    Baicalin Inhibitor
    Baicalin, one the effective compositions of scutellaria baicalensis, possesses multiple properities such as antioxidant, anti-tumor, anti-HIV, treating cardiovascular disease and so on.
  • HY-N0044
    Ginsenoside Re Inhibitor
    Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.
  • HY-N0342
    Scopoletin Inhibitor
    Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-κB and p38 MAPK. Scopoletin cause significant suppression of sprouting of microvessels in rat aortic explants with IC50 of 0.06 μM.