1. Signaling Pathways
  2. NF-κB
  3. NF-κB
  4. NF-κB Degrader

NF-κB Degrader

NF-κB Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-49444
    EN450
    Degrader 99.28%
    EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.