1. Stem Cell/Wnt
  2. β-catenin

β-catenin

β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

β-catenin Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-15147
    XAV-939 Inhibitor 98.24%
    XAV-939 is a selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 values of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively.
  • HY-15597
    Salinomycin Inhibitor >98.0%
    Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex.
  • HY-19940
    TD139 Inhibitor 99.39%
    TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM.
  • HY-17577
    Berberine chloride hydrate Activator 99.11%
    Berberine has shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells; MAPK and Wnt/β-catenin pathways affected by Berberine.
  • HY-11035
    WAY-262611 Agonist 99.08%
    WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay.
  • HY-101486
    LF3 Antagonist 98.58%
    LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM.
  • HY-101090
    KYA1797K Inhibitor >98.0%
    KYA1797K is a potent and selective Wnt/β-catenin inhibitor with an IC50 of 0.75 µM.
  • HY-102028
    KY1220 >98.0%
    KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.
  • HY-15721
    FH535 Inhibitor 99.90%
    FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
  • HY-101130
    PNU-74654 Inhibitor 99.60%
    PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.
  • HY-16910
    WIKI4 Inhibitor 99.70%
    WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
  • HY-13719
    Oleandrin Inhibitor 99.84%
    Oleandrin (a toxic cardiac glycoside of N. oleander L.) inhibits the activity of NF-κB in various cultured cell lines (U937, CaOV3, human epithelial cells and T cells) as well as it induces programmed cell death in PC3 cell line culture.
  • HY-12319A
    Cardiogenol C hydrochloride Activator 98.03%
    Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
  • HY-B1057
    Nefopam hydrochloride Inhibitor 99.59%
    Nefopam is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain.
  • HY-18258
    Berberine chloride Activator
    Berberine has shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells; MAPK and Wnt/β-catenin pathways affected by Berberine.
  • HY-32736
    Triptonide Inhibitor 98.89%
    Triptonide(NSC 165677; PG 492), extracted from Tripterygium wilfordii Hook, inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 mg/ml.
  • HY-B0012
    Pamidronic acid
    Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.