1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

Sirtuin

Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Related Products (22):

Cat. No. Product Name Effect Purity
  • HY-15452
    EX-527 Inhibitor 99.69%
    EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
  • HY-15145
    SRT 1720 Hydrochloride Activator 98.79%
    SRT 1720 Hydrochloride is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.
  • HY-13515
    Sirtinol Inhibitor >98.0%
    Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
  • HY-15262
    SRT 2104 Activator 99.60%
    SRT 2104 is a small molecule Sirtuin 1 activator.
  • HY-15510B
    Tenovin 6 Hydrochloride Inhibitor >98.0%
    Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively.
  • HY-108331
    3-TYP Inhibitor 99.87%
    3-TYP is a selective SIRT3 inhibitor, with an IC50 of 38 μM, and selectively inhibits Sirt3 over Sirt1 and Sirt2.
  • HY-100732
    Cambinol Inhibitor 98.57%
    Cambinol is a SIRT1 and SIRT1 inhibitor with IC50 values of 56 and 59 μM, respectively.
  • HY-N0182
    Fisetin >98.0%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-13423
    Tenovin-1 Inhibitor 99.39%
    Tenovin-1 is a inhibitor of SIRT1 and SIRT2; activator of p21 and p53.
  • HY-15869
    Inauhzin Inhibitor 98.91%
    Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
  • HY-101278
    Thiomyristoyl Inhibitor 98.84%
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
  • HY-15510
    Tenovin-6 Inhibitor 98.24%
    Tenovin-6 is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively.
  • HY-16691
    AK-7 Inhibitor 99.59%
    AK-7 is a selective and brain-permeable SIRT2 inhibitor; is neuroprotective in Huntington disease mouse models.
  • HY-101073
    Salermide Inhibitor >98.0%
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
  • HY-19758A
    Sirtuin modulator 1 Modulator
    Sirtuin modulator 1 is a sirtuin modulator extracted from patent WO/2010071853 A1, compound 570, with EC1.5 <1 uM.
  • HY-10532
    SRT 1720 Activator
    SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.
  • HY-15452A
    EX-527 S-enantiomer Inhibitor 98.29%
    EX-527 S-enantiomer is the S-enantiomer of EX-527, with an IC50 of 123 nM for SIRT1.
  • HY-101465
    AK-1 Inhibitor >98.0%
    AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor.
  • HY-15452B
    EX-527 R-enantiomer
    EX-527 R-enantiomer is the less active R-enantiomer of EX-527, with an IC50 of > 100 μM for SIRT1.
  • HY-N0785
    Ginkgolide C Activator
    Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.