1. Membrane Transporter/Ion Channel
  2. BCRP

BCRP

BCRP(breast cancer resistant protein) is an ATP-binding cassette (ABC) transporter, which together with two other ABC efflux drug pumps, namely P-glycoprotein (P-gp, ABCB1) and multidrug resistance-related protein 1 (MRP1, ABCC1) is the most important multidrug resistance protein found in eukaryotic cells including cells in the testis.

Breast cancer resistance protein (BCRP/ABCG2) is known to localize at the blood-brain barrier (BBB) and can significantly restrict xenobiotic permeability in the brain. The objective of this study is to investigate the regulation of BCRP functional expression by peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor primarily involved in lipid metabolism, in a cerebral microvascular endothelial cell culture system (hCMEC/D3), representative of human BBB.

BCRP Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-10010
    Ko 143 Inhibitor 98.74%
    Ko 143 is a practical breast cancer resistance protein multidrug transporter inhibitor BCRP, with the EC90 value of 26 nM.
  • HY-50879
    Elacridar Inhibitor 98.82%
    Elacridar is a potent P-glycoprotein (Pgp) and BCRP inhibitor, used for cancer treatment.
  • HY-19753
    KS176 Inhibitor 98.92%
    KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
  • HY-12757
    YHO-13177 Inhibitor 99.91%
    YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.
  • HY-12758A
    YHO-13351 free base Inhibitor
    YHO-13351 (free base) is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.
  • HY-N2143
    Fumitremorgin C Inhibitor
    Fumitremorgin C is a potent and selective ABCG2/BRCP inhibitor.
  • HY-12758
    YHO-13351 Inhibitor
    YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.