2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Src
  5. Lck Isoform

Lck

 

Lck Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-112291
    SB 220025
    		Inhibitor
    SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM). SB 220025 also inhibits p56Lck and PKC with IC50 values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation.
  • HY-163278
    Lck-IN-2
    		Inhibitor
    Lck-IN-2 (compound 12a) is an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck) with IC50 of 10.6 nM. Lck-IN-2 reveals efficacy in colon cancer cells with GI50s of 0.24-1.26 μM. Lck-IN-2 exhibits an apoptotic effect in Colo201 cells.
Cat. No. Product Name / Synonyms Application Reactivity