1. Protein Tyrosine Kinase/RTK
  2. c-Fms

c-Fms

c-FMS (CSF1R) is located at the cell plasma membrane. c-FMS is the receptor for the ligand colony stimulating factor-1 (CSF1). c-FMS is an integral transmembrane glycoprotein that exhibits ligand-induced tyrosine-specific protein kinase activity, which triggers a signaling cascade eventually affecting transcription of CSF1-responsive genes. c-FMS tyrosine phosphorylation is induced upon binding of CSF1, leading to activation of Ras/Erk and class I-A phosphatidylinositol 3-kinase signaling pathways, which in turn activate the signal transducers and activators of transcription (STATs) pathways, specifically STAT1, STAT3, and STAT5. c-FMS activation by CSF1 results in increased growth, proliferation and differentiation.

c-Fms Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-16749
    Pexidartinib Inhibitor 98.86%
    Pexidartinib(PLX-3397) is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
  • HY-12768
    BLZ945 Inhibitor 98.57%
    BLZ945 is a brain-penetrant CSF-1R inhibitor.
  • HY-10917
    GW2580 Inhibitor 99.34%
    GW2580 is an orally bioavailable inhibitor of c-FMS kinase; completely inhibited human cFMS kinase in vitro at 0.06 microM and was inactive against 26 other kinases.
  • HY-12009
    Pazopanib Hydrochloride Inhibitor 99.92%
    Pazopanib Hydrochloride is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
  • HY-10408
    Ki20227 Inhibitor 99.45%
    Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFRβ(IC50=451/217 nM), respectively.
  • HY-18787
    cFMS-IN-2 Inhibitor 99.05%
    cFMS-IN-2 is a FMS kinase inhibitor with an IC50 of 0.024 μM.
  • HY-10204
    OSI-930 Inhibitor 99.82%
    OSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl.
  • HY-13838
    PLX647 Inhibitor
    PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively.
  • HY-13075
    c-FMS inhibitor Inhibitor 99.39%
    c-FMS inhibitor is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent.