1. Anti-infection
  2. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (72):

Cat. No. Product Name Effect Purity
  • HY-12320
    Cycloheximide Inhibitor
    Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
  • HY-16321
    Micafungin sodium Inhibitor
    Micafungin (sodium) is an inhibitor of 1, 3-beta-D-glucan synthesis, and used as an antifungal drug.
  • HY-B0490
    Hygromycin B Inhibitor
    Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
  • HY-B0221
    Amphotericin B Inhibitor
    Amphotericin B is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
  • HY-17409
    Nystatin Inhibitor
    Nystatin is a polyene antifungal antibiotic effective against yeast and mycoplasma.
  • HY-101401
    3-(Methylthio)propionic acid Inhibitor
    3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.
  • HY-100666
    Fosfluconazole Inhibitor
    Fosfluconazole is a prodrug of Fluconazole that is widely used as an antifungal agent.
  • HY-N2145
    4',7-Dimethoxyisoflavone Inhibitor
    4',7-Dimethoxyisoflavone is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity.
  • HY-17006
    Caspofungin Acetate Inhibitor
    Caspofungin (Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-d glucan synthase activity.
  • HY-17373
    Posaconazole Inhibitor
    Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
  • HY-13553
    Anidulafungin Inhibitor
    Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
  • HY-17514
    Itraconazole Inhibitor
    Itraconazole is a triazole antifungal agent.
  • HY-17395A
    Terbinafine Inhibitor
    Terbinafine is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.
  • HY-14283
    Luliconazole Inhibitor
    Luliconazole(NND 502) is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.
  • HY-12772
    Itraconazole metabolite Hydroxy Itraconazole Inhibitor
    Itraconazole metabolite Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
  • HY-B0105
    Ketoconazole Inhibitor
    Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-13557
    Ascomycin Inhibitor
    Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
  • HY-B0139
    Flucytosine Inhibitor
    Flucytosine (5-Fluorocytosine, 5-FC, Ancobon), a fluorinated pyrimidine analogue, is an antifungal drug.
  • HY-10882
    Clotrimazole Inhibitor
    Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.
  • HY-14273
    Isavuconazole Inhibitor
    Isavuconazole(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.