1. Membrane Transporter/Ion Channel
  2. P-glycoprotein

P-glycoprotein

P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

P-glycoprotein Related Products (16):

Cat. No. Product Name Effect Purity
  • HY-50879
    Elacridar Inhibitor 98.47%
    Elacridar is a potent P-glycoprotein (Pgp) and BCRP inhibitor, used for cancer treatment.
  • HY-50671
    Zosuquidar trihydrochloride Inhibitor 98.75%
    Zosuquidar trihydrochloride is an inhibitor of P-glycoprotein with a Ki value of 59 nM.
  • HY-10550A
    Tariquidar methanesulfonate, hydrate Inhibitor 99.67%
    Tariquidar methanesulfonate, hydrate is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
  • HY-17384
    Valspodar Inhibitor 99.27%
    Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator.
  • HY-10550
    Tariquidar Inhibitor 98.57%
    Tariquidar is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
  • HY-101530
    Polyoxyethylene stearate
    Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.
  • HY-13574A
    Biricodar Modulator
    Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.
  • HY-U00247
    MCI826 Agonist
    Biricodar is a P-glycoprotein (P-gp) antagonist and enhances C6-ceramide cytotoxicity.
  • HY-N0797
    (20S)-Protopanaxadiol Inhibitor >98.0%
    protopanaxadiol-type ginseng saponin; apoptosis inducer.
  • HY-17013A
    Dofequidar fumarate Inhibitor 99.66%
    Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.
  • HY-N0144
    Piperine Inhibitor 98.76%
    Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
  • HY-13646
    HM30181 Inhibitor
    HM30181 is a potent and selective inhibitor of P-glycoprotein.
  • HY-15255
    Zosuquidar Inhibitor
    Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
  • HY-17013
    Dofequidar Inhibitor
    Dofequidar(MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.
  • HY-50880
    Elacridar hydrochloride Inhibitor
    Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
  • HY-N0854
    Alisol F Inhibitor
    Alisol F is a natural product.