1. Membrane Transporter/Ion Channel
  2. P-glycoprotein

P-glycoprotein

P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

P-glycoprotein Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-50879
    Elacridar Inhibitor
    Elacridar is a potent P-glycoprotein (Pgp) and BCRP inhibitor, used for cancer treatment.
  • HY-17384
    Valspodar Inhibitor
    Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator.
  • HY-50671
    Zosuquidar trihydrochloride Inhibitor
    Zosuquidar trihydrochloride is an inhibitor of P-glycoprotein with a Ki value of 59 nM.
  • HY-10550A
    Tariquidar methanesulfonate, hydrate Inhibitor
    Tariquidar methanesulfonate, hydrate is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
  • HY-10550
    Tariquidar Inhibitor
    Tariquidar is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
  • HY-13646
    HM30181 Inhibitor
    HM30181 is a potent and selective inhibitor of P-glycoprotein.
  • HY-N0144
    Piperine Inhibitor
    Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
  • HY-17013A
    Dofequidar fumarate Inhibitor
    Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.
  • HY-N0797
    (20S)-Protopanaxadiol Inhibitor
    protopanaxadiol-type ginseng saponin; apoptosis inducer.
  • HY-15255
    Zosuquidar Inhibitor
    Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
  • HY-17013
    Dofequidar Inhibitor
    Dofequidar(MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.
  • HY-50880
    Elacridar hydrochloride Inhibitor
    Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
  • HY-N0854
    Alisol F Inhibitor
    Alisol F is a natural product.