1. PI3K/Akt/mTOR
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Astragalus polysaccharide (Synonyms: Astragalus Polysacharin)

Cat. No.: HY-N0937
Handling Instructions

Astragalus polysaccharide, as one kind of biological macromolecule extracted from Astragalus, has antiviral activities.

For research use only. We do not sell to patients.
Astragalus polysaccharide Chemical Structure

Astragalus polysaccharide Chemical Structure

CAS No. : 89250-26-0

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Description

Astragalus polysaccharide, as one kind of biological macromolecule extracted from Astragalus, has antiviral activities. IC50 value: Target: In vitro: Adding astragalus polysaccharide before PCV2 infection decreased significantly PCV2 DNA copies, the number of infected cells, MDA level, ROS level and NF-κB activation in PK15 cells and increased significantly GSH contents and SOD activity compared to control without astragalus polysaccharide [1]. H2O2 induced oxidative damage in MRC-5 cells in a concentration-dependent manner. We chose the oxidative damage model induced by 800 μmol/L H2O2 for 24 hours to further study the protective mechanism of APS. Compared with H2O2 control groups, 200 mg/L APS significantly increased the protein level of APE/Ref-1 and TRX, decreased the content of 8-OHdG and the apoptosis of MRC-5 cells, and improved dramatically the cell viability [2]. In vivo: Spragne-Dawley rats were treated with astragalus polysaccharide (0.5 g/kg/day, once daily), astragalus polysaccharide administration enhanced the expression of T-bet (P=0.04) and GATA-3 (P=0.019) in comparison to TNBS group, and resulting in an up-regulated GATA-3/T-bet ratio [3].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01720550 PhytoHealth Corporation Cancer-related Fatigue November 2012 Phase 4
NCT02740959 Taipei Medical University Cancer-related Fatigue March 2016
NCT01720563 PhytoHealth Corporation Cancer-related Fatigue December 2012 Phase 2
NCT03089892 Tri-Service General Hospital Cancer-related Fatigue|Gynecologic Cancer|Chemotherapy October 19, 2016
NCT01603667 China Medical University Hospital|National Taiwan University Hospital|Shin Kong Wu Ho-Su Memorial Hospital|Tri-Service General Hospital|Changhua Christian Hospital|National Cheng-Kung University Hospital|Kaohsiung Medical University|En Chu Kong Hospital|Kuang Tien General Hospital|Chung Shan Medical University|Taipei Veterans General Hospital, Taiwan|Kaohsiung Veterans General Hospital.|Taipei Medical University Shuang Ho Hospital|Cheng Hsin Rehabilitation Medical Center|Taipei Medical University WanFang Hospital Acute Stroke June 2012 Phase 2
NCT01325233 PhytoHealth Corporation Hemorrhagic Stroke March 2011 Early Phase 1
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References
M.Wt

254.69

Formula

C₁₀H₇ClN₂O₂S

CAS No.

89250-26-0

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Astragalus polysaccharide
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HY-N0937
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