1. PI3K/Akt/mTOR
  2. Akt

Astragalus polysaccharide (Synonyms: Astragalus Polysacharin)

Cat. No.: HY-N0937
Handling Instructions

Astragalus polysaccharide, as one kind of biological macromolecule extracted from Astragalus, has antiviral activities.

For research use only. We do not sell to patients.
Astragalus polysaccharide Chemical Structure

Astragalus polysaccharide Chemical Structure

CAS No. : 89250-26-0

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Description

Astragalus polysaccharide, as one kind of biological macromolecule extracted from Astragalus, has antiviral activities. IC50 value: Target: In vitro: Adding astragalus polysaccharide before PCV2 infection decreased significantly PCV2 DNA copies, the number of infected cells, MDA level, ROS level and NF-κB activation in PK15 cells and increased significantly GSH contents and SOD activity compared to control without astragalus polysaccharide [1]. H2O2 induced oxidative damage in MRC-5 cells in a concentration-dependent manner. We chose the oxidative damage model induced by 800 μmol/L H2O2 for 24 hours to further study the protective mechanism of APS. Compared with H2O2 control groups, 200 mg/L APS significantly increased the protein level of APE/Ref-1 and TRX, decreased the content of 8-OHdG and the apoptosis of MRC-5 cells, and improved dramatically the cell viability [2]. In vivo: Spragne-Dawley rats were treated with astragalus polysaccharide (0.5 g/kg/day, once daily), astragalus polysaccharide administration enhanced the expression of T-bet (P=0.04) and GATA-3 (P=0.019) in comparison to TNBS group, and resulting in an up-regulated GATA-3/T-bet ratio [3].

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.9263 mL 19.6317 mL 39.2634 mL
5 mM 0.7853 mL 3.9263 mL 7.8527 mL
10 mM 0.3926 mL 1.9632 mL 3.9263 mL
M.Wt

254.69

Formula

C₁₀H₇ClN₂O₂S

CAS No.

89250-26-0

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

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Product Name:
Astragalus polysaccharide
Cat. No.:
HY-N0937
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