1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase

CHF5074 (Synonyms: CSP-1103; Itanapraced)

Cat. No.: HY-14399
Handling Instructions

CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

For research use only. We do not sell to patients.
CHF5074 Chemical Structure

CHF5074 Chemical Structure

CAS No. : 749269-83-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

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Description

CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively. IC50 value: 3.6 μM (Aβ42), 18.4 μM (Aβ40) [1] Target: γ-secretase in vitro: CHF5074 significantly reduces the area occupied by plaques and the number of plaques in cortex and hippocampus. CHF5074 concentration reach in the brain (6.4 μM) were enough to efficiently inhibit A42 secretion (cell-based IC50 3.6 μM). CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. [1] CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. CHF5074 significantly reduces the apoptosis in hippocampal neurons exposed to OGD, as revealed by cleaved-caspase-3 immunoreactivity and TUNEL staining.[2] in vivo: CHF5074 was well tolerated by Tg2576 mice. In rats, CHF5074 is orally well absorbed (50%), and it is slowly eliminated from plasma. In young Tg2576 transgenic mice, short-term oral dosing with CHF5074 causes dose-dependent reduction of plasma Aβ42. [1]

Clinical Trial
References
Molecular Weight

325.16

Formula

C₁₆H₁₁Cl₂FO₂

CAS No.

749269-83-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 37 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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CHF5074
Cat. No.:
HY-14399
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