1. NF-κB
    Stem Cell/Wnt
  2. NF-κB
    β-catenin

Oleandrin 

Cat. No.: HY-13719 Purity: 99.84%
Data Sheet SDS Handling Instructions

Oleandrin (a toxic cardiac glycoside of N. oleander L.) inhibits the activity of NF-κB in various cultured cell lines (U937, CaOV3, human epithelial cells and T cells) as well as it induces programmed cell death in PC3 cell line culture.

For research use only. We do not sell to patients.
Oleandrin Chemical Structure

Oleandrin Chemical Structure

CAS No. : 465-16-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $355 In-stock
2 mg $180 In-stock
5 mg $280 In-stock
10 mg $480 In-stock
25 mg $850 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

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Description

Oleandrin (a toxic cardiac glycoside of N. oleander L.) inhibits the activity of NF-κB in various cultured cell lines (U937, CaOV3, human epithelial cells and T cells) as well as it induces programmed cell death in PC3 cell line culture. Target: NF-κB in vitro: Oleandrin inhibits proliferation of tumor cells and inhibits the excretion of fibroblast growth factor-2 (FGF-2) through membrane interaction and through inhibition of the Na, K-ATPase pump. In PANC-1 cells (human pancreatic cancer cell line), cell death occurs not through apoptosis, but rather through autophagy and it has been noticed that Oleandrin at low nanomolar concentrations potently inhibited cell proliferation associated with induction of a profound G(2)/M cell cycle arrest. Inhibition of cell cycle is not accompanied by any significant sub G1 accumulation of cells, suggesting a non-apoptotic mechanism of Oleandrin. [1] Oleandrin suppresses the activity of Wnt/β-catenin signaling pathway. Oleandrin downregulates the target gene expression of the Wnt/β-catenin pathway at both the mRNA and protein levels. Oleandrin inhibits the protein expression of β-catenin and reduces its nuclear localization. In addition, Oleandrin suppresses the activities of MMP-2 and MMP-9. Oleandrin also induces apoptosis in human leukemia cells through the dephosphorylation of Akt and expression of Fas L, as well as by altering the membrane fluidity. [2] in vivo: Oleandrin has lipophilic property and it can be easily absorbed in the gastrointestinal tract after oral dosing. Oleandrin is metabolized into oleandrigenin in mice. Oleandrin is rapidly absorbed after oral dosing (Cmax at 20 min) although the elimination half-life is longer (2.3 ± 0.5 h) than that after i.v. dosing (0.4 ± 0.1 h). In mouse studies, Oleandrin rapidly accumulates in brain tissue as it can pass through the blood-brain barrier. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7339 mL 8.6697 mL 17.3394 mL
5 mM 0.3468 mL 1.7339 mL 3.4679 mL
10 mM 0.1734 mL 0.8670 mL 1.7339 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

576.72

Formula

C₃₂H₄₈O₉

CAS No.

465-16-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Oleandrin
Cat. No.:
HY-13719
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