1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

PTACH (Synonyms: NCH-51)

Cat. No.: HY-12954 Purity: 99.36%
Handling Instructions

PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.

For research use only. We do not sell to patients.
PTACH Chemical Structure

PTACH Chemical Structure

CAS No. : 848354-66-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
5 mg USD 96 In-stock
10 mg USD 144 In-stock
50 mg USD 540 In-stock
100 mg USD 780 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

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  • References

Description

PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM. IC50 value: 1-10 μM (EC50) Target: HDAC in vitro: In cancer cell growth inhibition assay, PTACH shows strong activity. PTACH inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer, LOX-IMVI melanoma, SK-OV-3 ovarian cancer, RXF-631L renal cancer, St-4 stomach cancer, and DU-145 prostate cancer.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.5604 mL 12.8021 mL 25.6043 mL
5 mM 0.5121 mL 2.5604 mL 5.1209 mL
10 mM 0.2560 mL 1.2802 mL 2.5604 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

390.56

Formula

C₂₀H₂₆N₂O₂S₂

CAS No.

848354-66-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PTACH
Cat. No.:
HY-12954
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