1. Anti-infection
  2. Bacterial

Tedizolid phosphate (Synonyms: TR-701FA)

Cat. No.: HY-14855B
Handling Instructions

Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.

For research use only. We do not sell to patients.
Tedizolid phosphate Chemical Structure

Tedizolid phosphate Chemical Structure

CAS No. : 856867-55-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $140 In-stock
50 mg $500 In-stock
100 mg $770 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Tedizolid phosphate:

  • Biological Activity

  • Protocol

  • Technical Information

  • References


Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.

In Vitro

Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1].

In Vivo

For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT03009045 Los Angeles Biomedical Research Institute Bone and Joint Infection February 6, 2017 Phase 2
NCT02342418 Amit.Pai|Merck Sharp & Dohme Corp.|Albany College of Pharmacy and Health Sciences Obesity March 2015 Phase 4
NCT02620787 Hartford Hospital|Merck Sharp & Dohme Corp. Diabetes|Wound Infection|Healthy Volunteers February 23, 2016 Phase 1
NCT03217565 Merck Sharp & Dohme Corp. Gram-Positive Infections March 5, 2018 Phase 1
NCT02444234 University of Southern California|Merck Sharp & Dohme Corp. Cystic Fibrosis July 2015 Phase 4
NCT02750761 Merck Sharp & Dohme Corp. Gram-Positive Bacterial Infections May 2, 2016 Phase 1
NCT02276482 Cubist Pharmaceuticals LLC Skin Diseases, Infectious|Skin Diseases, Bacterial March 25, 2015 Phase 3
NCT02991131 Bayer Abscess|Cellulitis|Erysipelas|Wound Infection January 13, 2017
NCT02066402 Bayer|Merck Sharp & Dohme Corp. Bacterial Infections March 4, 2014 Phase 3
NCT02019420 Cubist Pharmaceuticals LLC Pneumonia January 6, 2014 Phase 3
NCT02477514 Merck Sharp & Dohme Corp. Skin Diseases, Bacterial June 2015 Phase 1
NCT01967225 Bayer Skin Diseases, Infectious November 2013 Phase 3
NCT00666601 Trius Therapeutics LLC Healthy April 2008 Phase 1
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Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2206 mL 11.1032 mL 22.2064 mL
5 mM 0.4441 mL 2.2206 mL 4.4413 mL
10 mM 0.2221 mL 1.1103 mL 2.2206 mL
Animal Administration

To induce a systemic S. pneumoniae infection, male ICR mice (weight, 18 to 20 g) are inoculated intraperitoneally with 1 of 4 PRSP isolates (DR9, DR10, DR11, or DR14) suspended in 10% mucin. The suspension contained sufficient bacteria to kill 100% of untreated control mice. At 1 h postinfection, mice receives a single dose of either tedizolid phosphate or linezolid, and survival is assessed daily for 7 days postinfection. Treatments are delivered both orally and intravenously at each of four doses (40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg), with 8 mice per group defined by dose, delivery method, and infecting strain. The 50% effective dose (ED50), i.e., the dose allowing survival of 50% of the infected mice, is calculated for each delivery route using probit analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 36 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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