1. Anti-infection
  2. Bacterial

Tedizolid phosphate (Synonyms: TR-701FA)

Cat. No.: HY-14855B
Handling Instructions

Torezolid phosphate is a novel oxazolidinone for gram-positive infections, has an IC50 of 8.7 μM and 5.7 μM for monoamine oxidase (MAO)-A and MAO-B, respectively.

For research use only. We do not sell to patients.
Tedizolid phosphate Chemical Structure

Tedizolid phosphate Chemical Structure

CAS No. : 856867-55-5

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $140 In-stock
50 mg $500 In-stock
100 mg $770 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Torezolid phosphate is a novel oxazolidinone for gram-positive infections, has an IC50 of 8.7 μM and 5.7 μM for monoamine oxidase (MAO)-A and MAO-B, respectively. IC50 Value: 8.7 μM (MAO-A); 5.7 μM (MAO-B) Target: Antibacterial Tedizolid Phosphate is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. It was developed for the treatment of acute bacterial skin and skin structure infections Tedizolid phosphate is a prodrug activated by plasma or intestinal phosphatases to tedizolid following administration of the drug either orally or intravenously. Once activated, tedizolid exerts its bacteriostatic microbial activity through inhibition of protein synthesis by binding to the 50S ribosomal subunit of the bacteria. Tedizolid phosphate was well tolerated following the oral administration of a once-daily 200-mg dose for three days.

Clinical Trial
Sponsor Condition Start Date Phase
Merck Sharp & Dohme Corp. Skin Diseases, Bacterial 2015-06-17 Phase 1
Cubist Pharmaceuticals Holdings LLC Skin Diseases, Infectious Skin Diseases, Bacteria 2014-10-09 Phase 3
References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2206 mL 11.1032 mL 22.2064 mL
5 mM 0.4441 mL 2.2206 mL 4.4413 mL
10 mM 0.2221 mL 1.1103 mL 2.2206 mL
References
M.Wt

450.32

Formula

C₁₇H₁₆FN₆O₆P

CAS No.

856867-55-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 36 mg/mL

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Tedizolid phosphate
Cat. No.:
HY-14855B
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