1. Anti-infection
  2. Bacterial

Tedizolid phosphate (Synonyms: TR-701FA)

Cat. No.: HY-14855B
Handling Instructions

Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.

For research use only. We do not sell to patients.
Tedizolid phosphate Chemical Structure

Tedizolid phosphate Chemical Structure

CAS No. : 856867-55-5

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $140 In-stock
50 mg $500 In-stock
100 mg $770 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.

In Vitro

Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1].

In Vivo

For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2206 mL 11.1032 mL 22.2064 mL
5 mM 0.4441 mL 2.2206 mL 4.4413 mL
10 mM 0.2221 mL 1.1103 mL 2.2206 mL
Animal Administration
[1]

To induce a systemic S. pneumoniae infection, male ICR mice (weight, 18 to 20 g) are inoculated intraperitoneally with 1 of 4 PRSP isolates (DR9, DR10, DR11, or DR14) suspended in 10% mucin. The suspension contained sufficient bacteria to kill 100% of untreated control mice. At 1 h postinfection, mice receives a single dose of either tedizolid phosphate or linezolid, and survival is assessed daily for 7 days postinfection. Treatments are delivered both orally and intravenously at each of four doses (40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg), with 8 mice per group defined by dose, delivery method, and infecting strain. The 50% effective dose (ED50), i.e., the dose allowing survival of 50% of the infected mice, is calculated for each delivery route using probit analysis.

References
M.Wt

450.32

Formula

C₁₇H₁₆FN₆O₆P

CAS No.

856867-55-5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 36 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Tedizolid phosphate
Cat. No.:
HY-14855B
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