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Products are for research use only. Not for human use. We do not sell to patients.

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A 922500

HY-10038

(DGAT-1 Inhibitor 4a; A-922500; A922500)

A 922500

A 922500 Chemical Structure

A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $116 In-stock
5 mg $105 In-stock
10 mg $147 In-stock
50 mg $469 In-stock
100 mg $700 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €114 In-stock
5 mg €103 In-stock
10 mg €144 In-stock
50 mg €460 In-stock
100 mg €686 In-stock
200 mg Get quote
500 mg Get quote

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Product name: A 922500
Cat. No.: HY-10038

A 922500 Data Sheet

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    Purity: 99.90%

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    DataSheet

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    NMR

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Biological Activity of A 922500

A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively.
IC50 Value: 7 nM(human DGAT-1); 24 nM(DGAT-1) [1]
Target: DGAT-1
in vitro: A 922500 potently inhibits huDGAT-1 and mseDGAT-1 [1]. A 922500 inhibits the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 with IC50 of 296 μM [2].
in vivo: Zucker fatty rats and diet-induced dyslipidemic hamsters were dosed orally with A-922500 (0.03, 0.3, and 3-mg/kg), a potent and selective DGAT-1 inhibitor, for 14 days. Serum triglycerides were significantly reduced by the 3 mg/kg dose of the DGAT-1 inhibitor in both the Zucker fatty rat (39%) and hyperlipidemic hamster (53%) [1]. A 922500 confers weight loss and a reduction in liver triglycerides when dosed chronically in DIO mice and depletes serum triglycerides following a lipid challenge in a dose-dependent manner, thus, reproducing major phenotypical characteristics of DGAT-1(-/-) mice [2]. The potent and selective DGAT-1 inhibitorA-922500 (0.03, 0.3 and 3 mg/kg, p.o.), dose-dependently attenuated the maximal postprandial rise in serum triglyceride concentrations in all species tested. At the highest dose of DGAT-1 inhibitor, the postprandial triglyceride response was abolished [3].
Clinical trial:
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 428.48 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C26H24N2O4
CAS No 959122-11-3
Solvent & Solubility

DMSO 86 mg/ml; Water < 1 mg/ml

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.3338 mL 11.6692 mL 23.3383 mL
5 mM 0.4668 mL 2.3338 mL 4.6677 mL
10 mM 0.2334 mL 1.1669 mL 2.3338 mL

References on A 922500

Inhibitor Kit

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