1. Metabolic Enzyme/Protease
  2. DGAT

A 922500 (Synonyms: DGAT-1 Inhibitor 4a; A-922500; A922500)

Cat. No.: HY-10038 Purity: 97.77%
Data Sheet SDS Handling Instructions

A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively.

For research use only. We do not sell to patients.
A 922500 Chemical Structure

A 922500 Chemical Structure

CAS No. : 959122-11-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $116 In-stock
5 mg $105 In-stock
10 mg $147 In-stock
50 mg $469 In-stock
100 mg $700 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

coe in vivo: Zucker fatty rats and diet-induced dyslipidemic hamsters were dosed orally with A-922500 (0.03, 0.3, and 3-mg/kg), a potent and selective DGAT-1 inhibitor, for 14 days. Serum triglycerides were significantly reduced by the 3 mg/kg dose of the DGAT-1 inhibitor in both the Zucker fatty rat (39%) and hyperlipidemic hamster (53%) [1]. A 922500 confers weight loss and a reduction in liver triglycerides when dosed chronically in DIO mice and depletes serum triglycerides following a lipid challenge in a dose-dependent manner, thus, reproducing major phenotypical characteristics of DGAT-1(-/-) mice [2]. The potent and selective DGAT-1 inhibitorA-922500 (0.03, 0.3 and 3 mg/kg, p.o.), dose-dependently attenuated the maximal postprandial rise in serum triglyceride concentrations in all species tested. At the highest dose of DGAT-1 inhibitor, the postprandial triglyceride response was abolished [3]. Clinical trial:

References
M.Wt

428.48

Formula

C₂₆H₂₄N₂O₄

CAS No.

959122-11-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
A 922500
Cat. No.:
HY-10038
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