1. Immunology/Inflammation
  2. FLAP

AM679 

Cat. No.: HY-14460 Purity: 99.80% ee.: 99.20%
Data Sheet SDS Handling Instructions

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.

For research use only. We do not sell to patients.
AM679 Chemical Structure

AM679 Chemical Structure

CAS No. : 1206880-66-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $396 In-stock
5 mg $260 In-stock
10 mg $336 In-stock
50 mg $906 In-stock
100 mg $1400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: 2.2 nM/0.6 nM/154 nM(FLAP binding/hLA/hWB) [1] Target: FLAP in vitro: AM679 showed excellent in vitro inhibition against FLAP. AM679 has an excellent hWB IC50 potency of 154 nM. AM679 showed an improved CYP inhibition profile (IC50 3A4 = 16.7 lM, 2C9 = 3.7 lM, 2D6 >30 lM), no time dependent inhibition against CYP3A4 (0.003 min-1 vs 0.057 min-1 for troleandomycin control 10 uM) and no CYP3A4 induction. in vivo: AM679 was profiled in a rodent bronchoalveolar lavage (BAL) model to measure its ability to inhibit production of leukotrienes in vivo.16 Oral administration of 39 (10 mg/kg as the sodium carboxylate salt) 4 h prior to ionophore challenge reduced LTB4 and CysLT levels in the rodent lung lavage fluid by 98% and 87%, respectively, with corresponding average rodent plasma levels of 605 nM (3 h post dose, rat blood LTB4 IC50 = 125 nM).

References
Molecular Weight

692.87

Formula

C₄₀H₄₄N₄O₅S

CAS No.

1206880-66-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AM679
Cat. No.:
HY-14460
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