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GW3965 hydrochloride

HY-10627A

(GW 3965 hydrochloride; GW-3965 hydrochloride)

GW3965 hydrochloride

GW3965 hydrochloride Chemical Structure

GW3965 Hcl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $102 In-stock
5 mg $75 In-stock
10 mg $120 In-stock
50 mg $450 In-stock
100 mg $810 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €100 In-stock
5 mg €74 In-stock
10 mg €118 In-stock
50 mg €441 In-stock
100 mg €794 In-stock
200 mg Get quote
500 mg Get quote

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Inquiry Information
Product name: GW3965 hydrochloride
Cat. No.: HY-10627A

GW3965 hydrochloride Data Sheet

  • View current batch:

    Purity: 99.60%

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    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

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Biological Activity of GW3965 hydrochloride

GW3965 Hcl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively.
IC50 value: 190/30 nM (hLXRα/β)
Target: LXR
GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. Angiotensin II-mediated increases in blood pressure can be reduced by GW3965 hydrochloride. In HepG2 cells, the EC50 for GW3965 is greater than 4 μM. In an animal study, GW3965 hydrochloride decreased lesion area by 53% 34% in male and female LDLR-/- mice, respectively. GW3965 induced expression of ATP-binding cassettes A1 and G1 in modified low-density lipoprotein-loaded macrophages in vitro as well as in the aortas of hyperlipidemic mice. Additionally, GW3965 hydrochloride increases ABCA1 gene expression and raises circulating HDL levels. GW3965 hydrochloride displays potent antiatherogenic activity in mouse models of atherosclerosis.

Chemical Information

M.Wt 618.51 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C33H32Cl2F3NO3
CAS No 405911-17-3
Solvent & Solubility

Soluble to 100 mM in DMSO and to 20 mM in ethanol

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.6168 mL 8.0839 mL 16.1679 mL
5 mM 0.3234 mL 1.6168 mL 3.2336 mL
10 mM 0.1617 mL 0.8084 mL 1.6168 mL

References on GW3965 hydrochloride

Other Forms

  • GW3965

    CAS No.: 405911-09-3 Get quote

Inhibitor Kit

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