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Signaling Pathway

I-BET151

HY-13235

(GSK1210151A; I-BET 151; GSK-1210151A; GSK 1210151A)

I-BET151

I-BET151 Chemical Structure

I-BET151(GSK1210151A) is a BET bromodomain inhibitor(pIC50=6.1,BRD4); I-BET151 blocks recruitment of BET to chromatin .

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $110 In-stock
5 mg $100 In-stock
10 mg $120 In-stock
50 mg $360 In-stock
100 mg $630 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €108 In-stock
5 mg €98 In-stock
10 mg €118 In-stock
50 mg €353 In-stock
100 mg €617 In-stock
200 mg Get quote
500 mg Get quote

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Product name: I-BET151
Cat. No.: HY-13235

I-BET151 Data Sheet

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    Purity: 99.19%

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Biological Activity of I-BET151

I-BET151(GSK1210151A) is a BET bromodomain inhibitor(pIC50=6.1,BRD4); I-BET151 blocks recruitment of BET to chromatin .
IC50 value: 6.1(pIC50) [1]
Target: BET bromodomain
I-BET151 induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively). I-BET151 reduces BCL2 expression in NOMO1 cells. I-BET151 improves survival in two rodents models of MLL-fusion leukemia in vivo.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 415.44 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C23H21N5O3
CAS No 1300031-49-5
Solvent & Solubility

DMSO 100 mM Ethanol 100 mM

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.4071 mL 12.0354 mL 24.0709 mL
5 mM 0.4814 mL 2.4071 mL 4.8142 mL
10 mM 0.2407 mL 1.2035 mL 2.4071 mL

References on I-BET151

Inhibitor Kit

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