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item/HY-B0125

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By Targets:	Antibiotic (11) Apoptosis (1) Bacterial (8) Biochemical Assay Reagents (2) Cannabinoid Receptor (1) Drug Intermediate (1) Endogenous Metabolite (7) Estrogen Receptor/ERR (1) Isotope-Labeled Compounds (3) Leukotriene Receptor (1) mTOR (1) Orthopoxvirus (3) Prostaglandin Receptor (1) Reference Standards (2) TGF-beta/Smad (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Infection (9) Inflammation/Immunology (2) Metabolic Disease (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: HyT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection Cancer
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-B0330D

(R)-Ofloxacin 1 Publications Verification Dextrofloxacin	Bacterial Antibiotic	Infection
(R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-W105318

Pentabromophenol PBP	TGF-beta/Smad Apoptosis	Cancer
Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs) .

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-145525

Linoleoyl-L-carnitine chloride CAR 18:2; C18:2 Carnitine; L-Carnitine linoleoyl ester	Endogenous Metabolite	Others
Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of Isoniazid (Item No. 20378) in mice.

HY-137555

11-dehydro-2,3-dinor Thromboxane B2 11-deHYdro-2,3-dinor TXB2	Endogenous Metabolite	Metabolic Disease
11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030). It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation. Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.

HY-B0125S1

Ofloxacin-d8	Bacterial Antibiotic	Infection
Ofloxacin-d₈ (Hoe-280-d8) is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.

HY-B0125S

Ofloxacin-d3 Hoe-280-d₃	Antibiotic Endogenous Metabolite Bacterial Orthopoxvirus Isotope-Labeled Compounds	Others
Ofloxacin-d₃ is the deuterium labeled Ofloxacin .

HY-W114419

Bisphenol C	Estrogen Receptor/ERR mTOR	Cardiovascular Disease Metabolic Disease
Bisphenol C is an estrogen receptor-α (ERα) agonist and an ERβ antagonist, with IC₅₀ values of 2.65 nM for ERα and 1.94 nM for ERβ. Bisphenol C is a material of manufacturing polyester polymers like polycarbonate, is widely used in daily items like water bottles, food packaging, textile and so on .

HY-B0125AS

Ofloxacin-d8 hydrochloride Hoe-280-d8 HYdrochloride	Isotope-Labeled Compounds Antibiotic Endogenous Metabolite	Others
Ofloxacin-d₈ (hydrochloride) is deuterium labeled Ofloxacin (hydrochloride).

HY-W739930

Desmethyl ofloxacin hydrochloride	Antibiotic	Infection
Desmethyl ofloxacin hydrochloride is a metabolite of the fluoroquinolone antibiotic Ofloxacin (HY-B0125).

HY-116661

Cannabigerovarin CBGV	Cannabinoid Receptor	Metabolic Disease
Cannabigerovarin (CRM) (Item No. 29117) is a certified reference material categorized as a phytocannabinoid.1 This product is intended for research and forensic applications.

HY-B0330DS

(R)-Ofloxacin-d3	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-B0330DR

(R)-Ofloxacin (Standard) Dextrofloxacin (Standard)	Reference Standards Bacterial Antibiotic	Infection
(R)-Ofloxacin (Standard) is the analytical standard of (R)-Ofloxacin (HY-B0330D). (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-P11040

Peptide P2.2	Bacterial Antibiotic	Infection
Peptide P2.2, a non-ribosomal peptide, is an antimicrobial peptide. Peptide P2.2 has potent antibacterial activity with MIC₅₀s of 4 and 32 μM for V. parahaemolyticus and V. alginolyticus, respectively. Peptide P2.2 increases synergistic antibacterial effects with antibiotics (such as Ofloxacin (HY-B0125) and Linezolid (HY-10394)) with negligible hemolytic activity. Peptide P2.2 disrupts bacterial membranes and increases permeability by modulating proteins involved in the type VI and III secretion systems. Peptide P2.2 can be used for bacterial infections research .

HY-130340

Teicoplanin A3-1 Teichomycin A3 factor 1; Antibiotic L 17054	Antibiotic	Infection
Teicoplanin A3-1 is a degradation product of teicoplanins A2-1 to 5 (Item Nos. 20187, 20188, 20189, 20192). Teicoplanins are glycopeptide antibiotics produced by A. teichomyceticus that are broadly effective against Gram-positive bacteria in vitro.

HY-124200

AL 8810 isopropyl ester	Prostaglandin Receptor	Endocrinology
AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).

HY-129303

AP219	Endogenous Metabolite	Metabolic Disease
AP39 (Item No. 17100) is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.

HY-134123

Lipoxin B4 methyl ester LXB4 metHYl ester	Drug Intermediate Leukotriene Receptor	Metabolic Disease
Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC₅₀ value of 0.3 nM.

HY-NP0251

Ofloxacin-BSA	Biochemical Assay Reagents	Inflammation/Immunology
Ofloxacin-BSA is a conjugate of Ofloxacin (HY-B0125) and BS. By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells .

HY-NP0251A

Ofloxacin-OVA	Biochemical Assay Reagents	Inflammation/Immunology
Ofloxacin-OVA is a conjugate of Ofloxacin (HY-B0125) and Ovalbumin (OVA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells .

Cat. No.	Product Name

HY-L0096V

Vitas-M Screening Compounds Library	1,400,000 compounds
Vitas-M Screening Compounds Library (stock) contains about 1,400,000 chemical substances. They are synthetic small molecule organic compounds for biological screening and lead optimization. Select any number of items as a "cherry pick".

HY-L055

Medicine Food Homology Compound Library	1,801 compounds
Medicine Food Homology (MFH) means that some food themselves are medicines and there is no absolute boundary between them. MFH theory combines the function of food and medicine together scientifically and MFH materials can be used both for food and medicine. Besides nutritional value, MFH materials also have the functions in the prevention and treatment of disease and many other healthcare effects. Food as medicines has many benefits because of their safety while taking drugs will bring inevitable side effect to people. In order to ensure the safe use of functional food, National Health Commission of People's Republic of China made specific provisions on MFH items. More than 100 kinds of widely used MFH materials have been released. Based on MFH items released by National Health Commission, PRC, MCE carefully designs a unique collection of 1,801 Medicine Food Homology Compounds with high safety that can be used for high throughput and high content screening for drug discovery.

Medicine Food Homology Compound Library

1,801 compounds

Medicine Food Homology (MFH) means that some food themselves are medicines and there is no absolute boundary between them. MFH theory combines the function of food and medicine together scientifically and MFH materials can be used both for food and medicine. Besides nutritional value, MFH materials also have the functions in the prevention and treatment of disease and many other healthcare effects. Food as medicines has many benefits because of their safety while taking drugs will bring inevitable side effect to people. In order to ensure the safe use of functional food, National Health Commission of People's Republic of China made specific provisions on MFH items. More than 100 kinds of widely used MFH materials have been released.

Based on MFH items released by National Health Commission, PRC, MCE carefully designs a unique collection of 1,801 Medicine Food Homology Compounds with high safety that can be used for high throughput and high content screening for drug discovery.

HY-L0088V

Life Chemicals 50K Diversity Library	50,240 compounds
Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.

Life Chemicals 50K Diversity Library

50,240 compounds

Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.

Cat. No.	Product Name	Type

HY-NP0251

Ofloxacin-BSA	Biochemical Assay Reagents
Ofloxacin-BSA is a conjugate of Ofloxacin (HY-B0125) and BS. By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells .

HY-NP0251A

Ofloxacin-OVA	Biochemical Assay Reagents
Ofloxacin-OVA is a conjugate of Ofloxacin (HY-B0125) and Ovalbumin (OVA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells .

Cat. No.	Product Name	Target	Research Area

HY-P11040

Peptide P2.2	Bacterial Antibiotic	Infection
Peptide P2.2, a non-ribosomal peptide, is an antimicrobial peptide. Peptide P2.2 has potent antibacterial activity with MIC₅₀s of 4 and 32 μM for V. parahaemolyticus and V. alginolyticus, respectively. Peptide P2.2 increases synergistic antibacterial effects with antibiotics (such as Ofloxacin (HY-B0125) and Linezolid (HY-10394)) with negligible hemolytic activity. Peptide P2.2 disrupts bacterial membranes and increases permeability by modulating proteins involved in the type VI and III secretion systems. Peptide P2.2 can be used for bacterial infections research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

Cat. No.	Product Name	Chemical Structure

HY-B0125S1

Ofloxacin-d8
Ofloxacin-d₈ (Hoe-280-d8) is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.

HY-B0125S

Ofloxacin-d3
Ofloxacin-d₃ is the deuterium labeled Ofloxacin .

HY-B0125AS

Ofloxacin-d8 hydrochloride
Ofloxacin-d₈ (hydrochloride) is deuterium labeled Ofloxacin (hydrochloride).

HY-B0330DS

(R)-Ofloxacin-d3
(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

(R)-Ofloxacin-d3

(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

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item/HY-B0125

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products