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N-Desethyl Sunitinib

HY-10873

(SU11662; SU 11662; SU-11662)

N-Desethyl Sunitinib

N-Desethyl Sunitinib Chemical Structure

N-desethyl sunitinib(SU-11662) is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).

Size Price Stock Quantity
10 mM * 1 mL in DMSO $339 In-stock
5 mg $308 In-stock
10 mg $350 In-stock
50 mg $1050 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €332 In-stock
5 mg €302 In-stock
10 mg €343 In-stock
50 mg €1029 In-stock
100 mg Get quote
200 mg Get quote

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Product name: N-Desethyl Sunitinib
Cat. No.: HY-10873

N-Desethyl Sunitinib Data Sheet

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    Purity: 98.32%

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Biological Activity of N-Desethyl Sunitinib

N-desethyl sunitinib(SU-11662) is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).
Targe: VEGFR; PDGFRβ
N-Desethyl Sunitinib is a major and pharmacologically active metabolite of the tyrosine kinase inhibitor and anticancer drug Sunitinib. Sunitinib also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib exhibits antiangiogenic and antitumor activity in multiple xenograft models.

Chemical Information

M.Wt 370.42 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H23FN4O2
CAS No 356068-97-8
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.6996 mL 13.4982 mL 26.9964 mL
5 mM 0.5399 mL 2.6996 mL 5.3993 mL
10 mM 0.2700 mL 1.3498 mL 2.6996 mL

References on N-Desethyl Sunitinib

Inhibitor Kit

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