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PF-04447943

HY-15441

(PF 04447943; PF04447943)

PF-04447943

PF-04447943 Chemical Structure

PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $275 In-stock
5 mg $250 In-stock
10 mg $450 In-stock
50 mg Get quote
100 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €270 In-stock
5 mg €245 In-stock
10 mg €441 In-stock
50 mg Get quote
100 mg Get quote

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Product name: PF-04447943
Cat. No.: HY-15441

PF-04447943 Data Sheet

  • View current batch:

    Purity: 98.74% ee.:99.97%

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    DataSheet

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    MSDS

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    COA

Related Compound Libraries

Biological Activity of PF-04447943

PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11.
IC50 value: 2.8 nM (Human recombinant PDE9)
Target: PDE 9
PF-04447943 increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. PF-04447943 was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer's disease.

Chemical Information

M.Wt 395.46 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H25N7O2
CAS No 1082744-20-4
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5287 mL 12.6435 mL 25.2870 mL
5 mM 0.5057 mL 2.5287 mL 5.0574 mL
10 mM 0.2529 mL 1.2644 mL 2.5287 mL

Clinical Information of PF-04447943

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
PF-04447943 Pfizer Inc Alzheimers disease 30-SEP-09 30-SEP-10 Phase 2 22-APR-13
Pfizer Inc Alzheimers disease 30-APR-10 01-JUL-10 Phase 1 14-SEP-13
Pfizer Inc Alzheimers disease 31-OCT-09 31-JUL-10 Phase 1 13-SEP-13
Pfizer Inc Cognitive disorder 31-AUG-09 01-NOV-09 Phase 1 14-SEP-13
Pfizer Inc Cognitive disorder 31-JAN-09 01-MAY-09 Phase 1 14-SEP-13
Pfizer Inc Cognitive disorder 30-APR-09 01-MAY-09 Phase 1 14-SEP-13

References on PF-04447943

Inhibitor Kit

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